Toxic Marrow Failure after Treatment of Carcinoma with Cytotoxic Drugs

Thiotepa in Treatment of Advanced Breast Cancer

“…We have not been able to obtain the same satisfactory results in advanced breast cancer as those reported by Watson and Turner (1959) or by Cree (1960), but it is clear that useful control of the disease was possible in some patients (Table D). Taking the group as a whole, one patient in three had objective benefit for an average period of 7.5 months.…”

“…Seven out of 34 of their patients were stage 2 cases; but, even if these are excluded, 23 of the remaining 27 patients with metastatic disease were said to show some measure of control. Cree (1960), using the same technique, had similar results in 17 patients.…”

Estimation of Thiotepa in Urine

“…Sm,-When given in doses sufficient to suppress malignant tumours, Thiotepa has been shown to cause a severe, and sometimes fatal, depression of the bone marrow (Cree, 1960). For this reason topical and localising methods of treatment have been sought and applied with some success (Abel, 1960).…”