Towards wound dressings with improved properties: Effects of poly(dimethylsiloxane) on chitosan-alginate films loaded with thymol and beta-carotene

Pires, Ana Luíza Resende; Motta, Liana de Azevedo; Dias, Alfredo M. P. G.; Sousa, Hermínio C. de; Moraes, Ângela Maria; Braga, Mara E.M.

doi:10.1016/j.msec.2018.08.005

Cited by 58 publications

(32 citation statements)

References 57 publications

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“…Drugs may act as plasticizers, modifying the three‐dimensional hydrogel structure. They may decrease the chains intermolecular interactions and increase the free volume and the mobility of the polymer chains, resulting in increased film thickness . As well as the addition of drugs, the addition of microparticles also increased the films' thickness .…”

Section: Resultsmentioning

confidence: 99%

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

Candido

Conceição

Moreira

et al. 2019

Polymers for Advanced Techs

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Alginate hydrogels have many attractive characteristics for potential use as wound dressing materials. However, they are not considered to possess any intrinsic activity against microbial infection, often present in neuropathic wounds. To overcome this, the effect of incorporating neomycin or propolis in alginate hydrogels was investigated, both by direct blending alone and also by further addition of loaded alginate microparticles prepared by the extrusion dripping method. The morphological, microstructural, thermal, mechanical, and swelling properties of each film were evaluated, as well as particle size distribution and antimicrobial penetration analysis. Microparticle size was considered suitable for drug delivery applications and incorporation in hydrogel films. The presence of neomycin and propolis, in both blended and microparticle form, interfered with film properties leading to hydrogels with different characteristics. All samples showed swelling degrees up to 100% and mechanical and thermal properties suitable for application as wound dressings. In addition, all samples acted as barriers to microbial penetration.

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Section: Resultsmentioning

confidence: 99%

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

Candido

Conceição

Moreira

et al. 2019

Polymers for Advanced Techs

View full text Add to dashboard Cite

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“…We compared our results with the ASTM F756-00 standard materials. Thus, hemolytic index ranging between 0 and 2% are considered as non-hemolytic while ranging 2–5% are slight hemolytic, and < 5% are classified as hemolytic ones (Pires et al 2018 ). Similar results were obtained by Kameneva et al ( 2003 ) where the PEG contact (any molecular weight) reduced the hemolysis rate of erythrocytes.…”

Section: Discussionmentioning

confidence: 99%

Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing

et al. 2020

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The interests in the biomedical impact of tannic acid (TA) targeting production of various types of biomaterials, such as digital microfluids, chemical sensors, wound dressings, or bioimplants constantly increase. Despite the significant disadvantage of materials obtained from natural-based compounds and their low stability and fragility, therefore, there is an imperative need to improve materials properties by addition of stabilizing formulas. In this study, we performed assessments of thin films over TA proposed as a cross-linker to be used in combination with polymeric matrix based on chitosan (CTS), i.e. CTS/TA at 80:20 or CTS/TA at 50:50 and poly(ethylene glycol) (PEG) at the concentration of 10% or 20%. We evaluated their mechanical parameters as well as the cytotoxicity assay for human bone marrow mesenchymal stem cells, human melanotic melanoma (MNT-1), and human osteosarcoma (Saos-2). The results revealed significant differences in dose-dependent of PEG regarding the maximum tensile strength (σmax) or impact on the metabolic activity of tissue culture plastic. We observed that PEG improved mechanical parameters prominently, decreased the hemolysis rate, and did not affect cell viability negatively. Enclosed data, confirmed also by our previous reports, will undoubtedly pave the path for the future application of tannic acid-based biomaterials to treat wound healing.

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“…As polydopamine can coat many surfaces, this approach may serve for functionalization of natural polymers too. Films based on CH-ALG were loaded with both thymol and β-Carotene to produce new wound dressings [ 234 ], unfortunately without deciphering the biological advantage of the antioxidants. A multiresponsive catechol-Fe 3+ coordination hydrogel (MICH) was designed by assembling together HA, dopamine, β-ciclodestrin, and vitamin E [ 142 ].…”

Section: Towards Therapeutic Application: Antioxidant Biomaterialsmentioning

confidence: 99%

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

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Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

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Towards wound dressings with improved properties: Effects of poly(dimethylsiloxane) on chitosan-alginate films loaded with thymol and beta-carotene

Cited by 58 publications

References 57 publications

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties

Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

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