Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing

Kaczmarek, Beata; Mazur, Olha; Miłek, Oliwia; Michalska‐Sionkowska, Marta; Osyczka, Anna M.; Kleszczyński, Konrad

doi:10.1007/s40204-020-00136-1

Cited by 15 publications

(10 citation statements)

References 42 publications

(48 reference statements)

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“…It should, however, be noted that an increased number of hydroxyl groups in the resulting biomaterials determines elevated water binding. It is highly desirable that the moisture environment is constantly maintained, avoiding skin dehydration and scar formation during wound healing, as previously shown [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing

Kaczmarek-Szczepańska

Ostrowska

Kozłowska

et al. 2021

IJMS

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The development of scaffolds mimicking the extracellular matrix containing bioactive substances has great potential in tissue engineering and wound healing applications. This study investigates melatonin—a methoxyindole present in almost all biological systems. Melatonin is a bioregulator in terms of its potential clinical importance for future therapies of cutaneous diseases. Mammalian skin is not only a prominent melatonin target, but also produces and rapidly metabolizes the multifunctional methoxyindole to biologically active metabolites. In our methodology, chitosan/collagen (CTS/Coll)-contained biomaterials are blended with melatonin at different doses to fabricate biomimetic hybrid scaffolds. We use rat tail tendon- and Salmo salar fish skin-derived collagens to assess biophysical and cellular properties by (i) Fourier transform infrared spectroscopy—attenuated total reflectance (FTIR–ATR), (ii) thermogravimetric analysis (TG), (iii) scanning electron microscope (SEM), and (iv) proliferation ratio of cutaneous cells in vitro. Our results indicate that melatonin itself does not negatively affect biophysical properties of melatonin-immobilized hybrid scaffolds, but it induces a pronounced elevation of cell viability within human epidermal keratinocytes (NHEK), dermal fibroblasts (NHDF), and reference melanoma cells. These results demonstrate that this indoleamine accelerates re-epithelialization. This delivery is a promising technique for additional explorations in future dermatotherapy and protective skin medicine.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing

Kaczmarek-Szczepańska

Ostrowska

Kozłowska

et al. 2021

IJMS

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“…Tannic acid (TA) is a natural polyphenolic compound extracted from plants, composed of a central glucose connected to five digalloyl ester groups. Various studies have found that TA exhibits antibacterial, antioxidant, anti-inflammatory, and hemostatic properties, which are beneficial for accelerating wound healing [ 7 , 8 , 9 ]. Additionally, because of its good aqueous solubility, the bioavailability of TA is higher than other natural antimicrobials, such as curcumin, peppermint, cinnamon, and thymol [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Poly(Caprolactone)/Tannic Acid Scaffold as an Antibacterial Wound Dressing

et al. 2023

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Antibacterial wound dressings are promising materials to treat infected skin wounds, which greatly affect the wound-healing process. In this study, tannic acid (TA), a natural antibacterial agent, was successfully loaded by electrospinning into poly(caprolactone) (PCL) fibers in a high concentration. It is suggested that the addition of TA was beneficial for producing uniform and continuous PCL nanofibers. Hydrogen bonds existed between the PCL and TA molecules based on the analysis of FTIR spectra and DSC results. The interactions and continuous network improved the mechanical properties of the scaffolds. Meanwhile, increasing the amount of TA also enhanced the hydrophilicity and water absorption capacity of the scaffold, both of which are beneficial for accelerating wound healing. Moreover, a burst release of the TA in the initial stage and a controlled, steady release behavior over time contributed to the highly antibacterial properties of the PCL/TA scaffolds. The fabrication of the composite scaffold supplies a facile, efficient, and controllable approach to address the issue of antibacterial treatment in wound dressing.

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“…To further increase the crosslinking degree, iron was also added to the formulation. Indeed, the additional crosslinking by metal complexation with iron (III) was found to improve the physical properties of chitosan films while increasing the metabolic activity of cells cultured on the material surface [ 15 ]. Moreover, tannic acid–iron (II) complex was also reported as a coating of artemisinin-zeolite nanoparticles, displaying low toxicity towards normal L929 human cells [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Prolonged Antibacterial Activity in Tannic Acid–Iron Complexed Chitosan Films for Medical Device Applications

et al. 2023

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Healthcare-associated infections (HAIs) represent a global burden, leading to significant mortality and generating financial costs. One important cause of HAIs is the microbiological contamination of implantable medical devices. In this context, a novel antimicrobial drug-eluting system, based on chitosan and loaded with gentamicin, a broad-spectrum antibiotic, was developed. The effects of the addition of tannic acid and different FeSO4 concentrations on the loaded antibiotic release were evaluated. The properties of the films were assessed in terms of thickness, swelling, mass loss and wettability. The films’ surface composition was characterized by X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy. The antibiotic release in phosphate buffer saline was quantified by high-performance liquid chromatography–mass spectrometry, and the antibacterial activity was evaluated. Hemolysis and cytotoxicity were also assessed. The results showed that the addition of tannic acid and iron decreased the swelling degree and degradation due to strong interactions between the different components, thus impacting gentamicin release for up to 35 days. In conclusion, this study presents a novel strategy to produce low-cost and biocompatible antimicrobial drug-eluting systems with sustained and prolonged antibacterial activity over more than a month.

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Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing

Cited by 15 publications

References 42 publications

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing

Fabrication and Characterization of Electrospun Poly(Caprolactone)/Tannic Acid Scaffold as an Antibacterial Wound Dressing

Prolonged Antibacterial Activity in Tannic Acid–Iron Complexed Chitosan Films for Medical Device Applications

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