Towards bionic noses

Persaud, Krishna

doi:10.1108/sr-10-2016-0238

Cited by 8 publications

(4 citation statements)

References 53 publications

(57 reference statements)

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“…There, the interaction of the sample’s VOC molecules with the sensing materials generates signals that are transduced and processed by a computing unit. In the last decade, much work has been devoted to the development of optimized gas-sensors [ 5 , 20 , 21 , 22 ], signal processing [ 23 ], and device architectures [ 24 , 25 ], always targeting the ideal of a compact, miniaturized e-nose with accurate and selective performance. In particular, important effort has been put on the optimization of the sample preparation and delivery system.…”

Section: Introductionmentioning

confidence: 99%

Microfluidics in Gas Sensing and Artificial Olfaction

Rebordão

Palma

Roque

2020

Sensors

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Rapid, real-time, and non-invasive identification of volatile organic compounds (VOCs) and gases is an increasingly relevant field, with applications in areas such as healthcare, agriculture, or industry. Ideal characteristics of VOC and gas sensing devices used for artificial olfaction include portability and affordability, low power consumption, fast response, high selectivity, and sensitivity. Microfluidics meets all these requirements and allows for in situ operation and small sample amounts, providing many advantages compared to conventional methods using sophisticated apparatus such as gas chromatography and mass spectrometry. This review covers the work accomplished so far regarding microfluidic devices for gas sensing and artificial olfaction. Systems utilizing electrical and optical transduction, as well as several system designs engineered throughout the years are summarized, and future perspectives in the field are discussed.

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Section: Introductionmentioning

confidence: 99%

Microfluidics in Gas Sensing and Artificial Olfaction

Rebordão

Palma

Roque

2020

Sensors

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“…The mysteries of olfaction, in particular human olfaction, still intrigue scientists and, not surprisingly, it is considered the least understood sense [2,3]. Artificial olfaction systems aim to mimic the sense of smell and typically consist of electronic nose devices (e-noses) (see Glossary) that include an array of gas sensors associated with signal-processing tools [4–6]. Classically, in an e-nose, a sample enters the system through an inlet that guides the gas molecules to a chamber where the sensing material is deposited.…”

Section: Biosensors In Artificial Olfactionmentioning

confidence: 99%

“…The main drawbacks of these systems are the low stability and high promiscuity towards VOC molecules, resulting in low selectivity. As such, incorporating the sensing components of biological olfaction systems into gas-sensing materials can increase the VOC selectivity of the resultant gas sensors and bio-electronic noses (Figure 1) [4,6,19–22]. Still, most published works report biosensing using VOC analytes in solutions [23–27], in contrast to the real-life implementation of e-noses to analyse gaseous samples.…”

Section: Biosensors In Artificial Olfactionmentioning

confidence: 99%

Protein- and Peptide-Based Biosensors in Artificial Olfaction

Barbosa

Oliveira

Roque

2018

Trends in Biotechnology

102

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Animals' olfactory systems rely on proteins, olfactory receptors (ORs) and odorant-binding proteins (OBPs), as their native sensing units to detect odours. Recent advances demonstrate that these proteins can also be employed as molecular recognition units in gas-phase biosensors. In addition, the interactions between odorant molecules and ORs or OBPs are a source of inspiration for designing peptides with tunable odorant selectivity. We review recent progress in gas biosensors employing biological units (ORs, OBPs, and peptides) in light of future developments in artificial olfaction, emphasizing examples where biological components have been employed to detect gas-phase analytes.

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“…Therefore, there is an urgent demand for a high-performance sensor system to realize the effective detection of dangerous chemicals with ultra-high sensitivity and high specificity, and stability. With the rapid development of modern sensor technology, it is possible to design the detection strategies based on olfactory and gustatory related biomolecule elements as the first sensing element, which can combine with different detection devices as the second sensing element [ 52 , 53 , 54 ]. Such sensors are called biomimetic olfactory biosensors or biomimetic gustatory biosensors.…”

Section: Introductionmentioning

confidence: 99%

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

Chen

Tian

et al. 2022

Biosensors

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The biomimetic olfactory and gustatory biosensing devices have broad applications in many fields, such as industry, security, and biomedicine. The development of these biosensors was inspired by the organization of biological olfactory and gustatory systems. In this review, we summarized the most recent advances in the development of detection strategies for chemical sensing based on olfactory and gustatory biomimetic biosensors. First, sensing mechanisms and principles of olfaction and gustation are briefly introduced. Then, different biomimetic sensing detection strategies are outlined based on different sensing devices functionalized with various molecular and cellular components originating from natural olfactory and gustatory systems. Thereafter, various biomimetic olfactory and gustatory biosensors are introduced in detail by classifying and summarizing the detection strategies based on different sensing devices. Finally, the future directions and challenges of biomimetic biosensing development are proposed and discussed.

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Towards bionic noses

Cited by 8 publications

References 53 publications

Microfluidics in Gas Sensing and Artificial Olfaction

Microfluidics in Gas Sensing and Artificial Olfaction

Protein- and Peptide-Based Biosensors in Artificial Olfaction

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

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