Towards an antimicrobial ‘microglove’

Reilman, Ewoud; Hagting, Joke G.; Flipsen, Theo; Ulmer, Herb; Dijl, Jan Maarten van

doi:10.1038/srep16679

Cited by 4 publications

(2 citation statements)

References 25 publications

(28 reference statements)

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“…The impact of AgNPs‐coated gloves on the contamination of surfaces with S. aureus ATCC 25923, P. aeruginosa ATCC 27853, and C. albicans ATCC 90028, the subsequent pathogen transmission to other surfaces was evaluated using a method described previously. [ 10 ] Briefly, bacterial and yeast suspensions were adjusted to McFarland standard No. 0.5 (1.5 × 10 8 CFU mL –1 ) and spread onto tryptic soy agar (TSA) and SDA, respectively.…”

Section: Methodsmentioning

confidence: 99%

Prevention of nosocomial transmission and biofilm formation on novel biocompatible antimicrobial gloves impregnated with biosynthesized silver nanoparticles synthesized using Eucalyptus citriodora leaf extract

Paosen

Lethongkam

Wunnoo

et al. 2021

Biotechnology Journal

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Failure in the prevention of cross‐transmission from contaminated gloves has been recognized as an important factor that contributes to the spread of several healthcare‐associated infections. Ex situ coating process with silver nanoparticles (AgNPs) using Eucalyptus citriodora ethanolic leaf extract as reducing and capping agents to coat glove surfaces has been developed to prevent this mode of transmission. Elemental analysis of coated gloves showed 24.8 Wt% silver densely adhere on the surface. The coated gloves fully eradicated important hospital‐acquired pathogens including Gram‐positive bacteria, Gram‐negative bacteria, and yeasts within 1 h. The coated gloves showed significant reduction, an average of five logs when tested against all standard strains and most clinical isolates (p < 0.01). Following prolonged exposure, the coating significantly reduced the numbers of most adhered pathogenic species, compared with uncoated gloves (p < 0.0001). AgNPs‐coated gloves reduced microbial adhesion of mixed‐species biofilms. A series of contamination and transmission assays demonstrated no transmission of viable organisms. Biocompatibility analysis confirmed high viability of HaCaT and L929 cells at all concentrations of AgNPs tested. The coated gloves were non‐toxic with direct contact with L929 cells. The highly efficacious AgNPs‐coated gloves potentially provide additional protection against transmission of healthcare‐associated infections.

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Section: Methodsmentioning

confidence: 99%

Prevention of nosocomial transmission and biofilm formation on novel biocompatible antimicrobial gloves impregnated with biosynthesized silver nanoparticles synthesized using Eucalyptus citriodora leaf extract

Paosen

Lethongkam

Wunnoo

et al. 2021

Biotechnology Journal

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“…2012) and dye that can react with QACs through ionic complexation (Auerbach 1943; Reilman et al . 2015). Indeed, the BPB‐QACs complex absorbs light at a different wavelength than BPB alone (Auerbach 1943), thus leading to a change of colour detectable to the naked eye.…”

Section: Introductionmentioning

confidence: 99%

Colorimetric detection of residual quaternary ammonium compounds on dry surfaces and prediction of antimicrobial activity using bromophenol blue

Burel¹,

Direur²,

Rivas

et al. 2021

Letters in Applied Microbiology

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Controlling and monitoring the residual activity of quaternary ammonium compounds (QACs) are critical for maintaining safe yet effective levels of these agents in the environment. This study investigates the utility of bromophenol blue (BPB) as a safe, rapid and user‐friendly indicator to detect in situ residual QACs dried on hard, non‐porous surfaces, as well a means to assess their antimicrobial efficacy. At pH 7, BPB has a purple colour which turns blue upon its complexation with QACs such as didecyldimethylammonium chloride (DDAC). BPB itself has no antimicrobial properties up to 400 ppm. Within the range of 0–400 ppm, BPB colour change was tied to specific DDAC antimicrobial performances with a detection threshold of 100 ppm. BPB concentration and application volume could be adjusted such that a colour shift from purple to blue correlated with a set percent reduction (>99·9%) in test bacteria (Staphylococcus aureus and Klebsiella aerogenes). The BPB solutions developed in this study yielded similar colour shifts on polycarbonate and stainless steel surfaces and did not cross‐react with chemical ingredients commonly found in sanitizers and disinfectant products. Overall, this study suggests that BPB provides a simple solution to safely monitor the post‐application level and biocidal activity of residual dried QACs on surfaces.

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Functionalized starch microparticles for contact-active antimicrobial polymer surfaces

Ojogbo

Ward

Mekonnen

2020

Carbohydrate Polymers

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Towards an antimicrobial ‘microglove’

Cited by 4 publications

References 25 publications

Prevention of nosocomial transmission and biofilm formation on novel biocompatible antimicrobial gloves impregnated with biosynthesized silver nanoparticles synthesized using Eucalyptus citriodora leaf extract

Prevention of nosocomial transmission and biofilm formation on novel biocompatible antimicrobial gloves impregnated with biosynthesized silver nanoparticles synthesized using Eucalyptus citriodora leaf extract

Colorimetric detection of residual quaternary ammonium compounds on dry surfaces and prediction of antimicrobial activity using bromophenol blue

Functionalized starch microparticles for contact-active antimicrobial polymer surfaces

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