Toward 3D Printed Bioactive Titanium Scaffolds with Bimodal Pore Size Distribution for Bone Ingrowth

Maleksaeedi, Saeed; Wang, Jun Kit; El-Hajje, Aouni; Harb, Layale; Guneta, Vipra; He, Zeming; Wiria, Florencia Edith; Choong, Cleo; Ruys, Andrew J.

doi:10.1016/j.procir.2013.01.032

Cited by 55 publications

(34 citation statements)

References 16 publications

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“…4; on the bed which was controlled by a feed roller and deionized water which was used as a binder was dispersed by the printer head layer by layer according to the cross section of scaffold. Compressive modulus of 330 MPa was obtained for total scaffold porosity of 83 %, which is well in range for human cancellous bone (Maleksaeedi et al, 2013). …”

Section: Mechanical Testing Of 3d Printed Scaffold For Bone Tissue Rementioning

confidence: 53%

“…Not only pore size, but scaffold architecture and porosity also play an important role in enhancing the cell reaction in terms of seeding efficiency. Poly (ε-caprolactone) (PCL) scaffold with four different configurations of fibers (basic, basic-offset, crossed and crossed offset) each having mean porosities of about 60% showed more cell propagation and mesenchymal stem cell differentiation in offset structures when seeded with rat bone marrow (MSC) (Maleksaeedi et al, 2013). Scaffold fabricated by PPF using Microsteriolithography (MSTL) an additive manufacturing technology showed 30% more cell proliferation for staggered structure than lattice type when seeded with pre-osteoblast cells (Lee, Ahn, Kim, & Cho, 2010).…”

Section: Computer Assisted Scaffold Architectures For Bone Tissue Regmentioning

confidence: 99%

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Rapid Prototyping Assisted Scaffold Fabrication for Bone Tissue Regeneration

Sapkal¹,

Jaiswal²,

Kuthe³

2016

JMSR

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The review article focuses on Rapid Prototyped assisted scaffold fabrication for bone tissue regeneration, particularly in respect of its mechanical properties and cell culture abilities. The distinct feature of computer aided design and computer aided manufacturing (CAD & CAM), imaging technology and rapid prototyping (RP) technology has been used by different researchers to print porous scaffolds with requisite shape and interconnected channels for osseous tissue formation. This study concludes that the use of RP in scaffold manufacturing offers patient specific designed scaffolds with improved strength, in-vitro and in-vivo cell culture capability unlike traditional scaffold fabrication techniques. Tissue engineering using 3D Printing is a viable substitute for organ transplant, which requires willing donors to part with their organs. This study reviewed the benefits of RP/imaging/CAD-CAM to develop scaffolds for bone tissue regeneration and it serves those patients who could not be accurately treated by traditional means. The article is helpful to study the influence of RP in the field of organ transplant

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Section: Mechanical Testing Of 3d Printed Scaffold For Bone Tissue Rementioning

confidence: 53%

Section: Computer Assisted Scaffold Architectures For Bone Tissue Regmentioning

confidence: 99%

Rapid Prototyping Assisted Scaffold Fabrication for Bone Tissue Regeneration

Sapkal¹,

Jaiswal²,

Kuthe³

2016

JMSR

View full text Add to dashboard Cite

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“…Piezoelectric ink-jet controlled droplet deposition of gold nanoparticles has achieved aspect ratios >50 [28]. However, for polymers, PZT (lead zirconium titanate) printing with a poly(vinyl butyral) binder has achieved an aspect ratio of ~5, but needed >1000 layers [24].…”

Section: Generation Of Increased Surface Area Biocoatings Using Ink Jmentioning

confidence: 99%

“…Recent work has shown ink-jet printing to be able to create very complicated 3D structures that may be more structurally stable than tall pillars [28]. Improving the catalytic surface area has been reported to improve chemical processes [51] and can do the same for whole cell biocatalysis using this ink-jet coating method.…”

Section: Generation Of Increased Surface Area Biocoatings Using Ink Jmentioning

confidence: 99%

“…Ink-jet processes can create patterned reactive surfaces to generate very high surface-to-volume ratio coatings [24][25][26][27][28] and biocoatings [6][7][8]. Ink-jet droplet deposition is an established large surface area coating and 3D printing technology that can be controlled to precisely deliver droplets containing engineered microbes instead of pigment particles onto a substrate and create patterns of nanoporous microstructures with defined height and large surface area without resulting in cell death during rapid ink deposition and drying.…”

Section: Introductionmentioning

confidence: 99%

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Ink-Jet Printing of Gluconobacter oxydans: Micropatterned Coatings As High Surface-to-Volume Ratio Bio-Reactive Coatings

et al. 2013

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Abstract:We formulated a latex ink for ink-jet deposition of viable Gram-negative bacterium Gluconobacter oxydans as a model adhesive, thin, highly bio-reactive microstructured microbial coating. Control of G. oxydans latex-based ink viscosity by dilution with water allowed ink-jet piezoelectric droplet deposition of 30 × 30 arrays of two or three droplets/dot microstructures on a polyester substrate. Profilometry analysis was used to study the resulting dry microstructures. Arrays of individual dots with base diameters of ~233-241 µm were obtained. Ring-shaped dots with dot edges higher than the center, 2.2 and 0.9 µm respectively, were obtained when a one-to-four diluted ink was used. With a less diluted ink (one-to-two diluted), the microstructure became more uniform with an average height of 3.0 µm , but the ink-jet printability was more difficult. Reactivity of the ink-jet deposited microstructures following drying and rehydration was studied in a non-growth medium by oxidation of 50 g/L D-sorbitol to L-sorbose, and a high dot volumetric reaction rate was measured (~435 g· L −1 · h −1 ). These results indicate that latex ink microstructures generated by ink-jet printing may hold considerable potential for 3D fabrication of high surface-to-volume ratio biocoatings for use as microbial biosensors with the aim of coating microbes as reactive biosensors on electronic devices and circuit chips. OPEN ACCESSCoatings 2014, 4 2

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Additive Manufacturing of Titanium Alloys for Orthopedic Applications: A Materials Science Viewpoint

et al. 2018

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Titanium‐based orthopedic implants are increasingly being fabricated using additive manufacturing (AM) processes such as selective laser melting (SLM), direct laser deposition (DLD), and electron beam melting (EBM). These techniques have the potential to not only produce implants with properties comparable to conventionally manufactured implants, but also improve on standard implant models. These models can be customized for individual patients using medical data, and design features, such as latticing, hierarchical scaffolds, or features to complement patient anatomy, can be added using AM to produce highly functional patient‐anatomy‐specific implants. Alloying prospects made possible through AM allow for the production of Ti‐based parts with compositions designed to reduce modulus and stress shielding while improving bone fixation and formation. The design‐to‐process lead time can be drastically shortened using AM and associated post‐processing, making possible the production of tailored implants for individual patients. This review examines the process and product characteristics of the three major metallic AM techniques and assesses the potential for these in the increased global uptake of AM in orthopedic implant fabrication.

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Toward 3D Printed Bioactive Titanium Scaffolds with Bimodal Pore Size Distribution for Bone Ingrowth

Cited by 55 publications

References 16 publications

Rapid Prototyping Assisted Scaffold Fabrication for Bone Tissue Regeneration

Rapid Prototyping Assisted Scaffold Fabrication for Bone Tissue Regeneration

Ink-Jet Printing of Gluconobacter oxydans: Micropatterned Coatings As High Surface-to-Volume Ratio Bio-Reactive Coatings

Additive Manufacturing of Titanium Alloys for Orthopedic Applications: A Materials Science Viewpoint

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