Rapid Prototyping Assisted Scaffold Fabrication for Bone Tissue Regeneration

Abstract

The review article focuses on Rapid Prototyped assisted scaffold fabrication for bone tissue regeneration, particularly in respect of its mechanical properties and cell culture abilities. The distinct feature of computer aided design and computer aided manufacturing (CAD & CAM), imaging technology and rapid prototyping (RP) technology has been used by different researchers to print porous scaffolds with requisite shape and interconnected channels for osseous tissue formation. This study concludes that the use of RP in scaffold manufacturing offers patient specific designed scaffolds with improved strength, in-vitro and in-vivo cell culture capability unlike traditional scaffold fabrication techniques. Tissue engineering using 3D Printing is a viable substitute for organ transplant, which requires willing donors to part with their organs. This study reviewed the benefits of RP/imaging/CAD-CAM to develop scaffolds for bone tissue regeneration and it serves those patients who could not be accurately treated by traditional means. The article is helpful to study the influence of RP in the field of organ transplant

Antibacterial effect of 3D printed mesoporous bioactive glass scaffolds doped with metallic silver nanoparticles

“…For adequate cell attachment, proliferation and differentiation, scaffolds need to have a 3D interconnected porous hierarchical architecture and a suitable surface chemistry and topography. Since the 1990s, the rapid prototyping (RP) technique has been widely employed [18][19][20][21][22][23][24] for the 3D scaffolds manufacture with different scales of porosity that have been previously computer designed. The RP technique consist of a filament obtained by direct ink writing and extruding, from a small needle connected to a cartridge, printing layer by layer the scaffold with designed shape and dimensions by 3D computer-aided design.…”