Tough and self-healing hydrogels based on transient crosslinking by nanoparticles

Liang, Hong; Liu, Li; Zhang, Zhimin; Song, Jiazhuo; Li, Siliang; Chen, Kexin; Gao, Guanghui; Wang, Yu

doi:10.1039/d1sm01439k

Cited by 6 publications

(6 citation statements)

References 31 publications

(28 reference statements)

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“…The above situation indicates that the metal ions are successfully attached to SA. The shift of the amide band in metal ion cross-linked gel films, indicating the presence of intermolecular hydrogen bonds, is consistent with the large amount of free energy detected in XRD [21,22]. In conclusion, the FTIR results indicate the successful preparation of these metal ion cross-linked gel films.…”

Section: Ftirsupporting

confidence: 82%

Preparation of Ion2+-COS/SA Multifunctional Gel Films for Skin Wound Healing by an In Situ Spray Method

et al. 2022

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The rapid preparation of safe and efficient wound dressings that meet the needs of the entire repair process remains a major challenge for effective therapeutic wound healing. Natural, sprayable Ion2+-COS/SA multifunctional dual-network gel films created by the in situ coordination of chitooligosaccharide (COS), metal ions and sodium alginate (SA) using casting and an in-situ spray method were synthesized. The gel films exhibited excellent physicochemical properties such as swelling, porosity and plasticity at a COS mass fraction of 3%. Furthermore, at this mass fraction, the addition of bimetallic ions led to the display of multifunctional properties, including significant antioxidant, antibacterial and cytocompatibility properties. In addition, experiments in a total skin defect model showed that this multifunctional gel film accelerates wound healing and promotes skin regeneration. These results suggest that the sprayable Ion2+-COS/SA multifunctional pro-healing gel film may be a promising candidate for the clinical treatment of allodermic wounds.

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Section: Ftirsupporting

confidence: 82%

Preparation of Ion2+-COS/SA Multifunctional Gel Films for Skin Wound Healing by an In Situ Spray Method

et al. 2022

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“…An advantage of our setup is the accessibility of the experimental workflow, which relies on generic reagents and supplies. We adopted PA hydrogels because they are widely used in biochemistry and biotechnology and are of interest as materials for biomedical applications, − devices with shape memory, , storage, , soft robotics, , and drug delivery. − However, our approach may be adapted to use a different type of acrylamide- or acrylic acid-based hydrogels, such as polyethylene glycol diacrylate (PEGDA), ,, gelatin methacryloyl (GelMA), , methacrylated hyaluronic acid (MeHA), , poly(2-hydroxyethyl methacrylate) (PHEMA), , and poly( N -hydroxyethyl acrylamide) (pHEAA). , The porosity of all these gels can be varied by changing the monomer concentration and the monomer to cross-linker ratio. Some of these hydrogels, however, form under photo-cross-linking, making them incompatible or inefficient with the DNA photocleavage-based release mechanism proposed here.…”

Section: Discussionmentioning

confidence: 99%

“…52−54 However, our approach may be adapted to use a different type of acrylamide-or acrylic acid-based hydrogels, such as polyethylene glycol diacrylate (PEGDA), 25,55,56 gelatin methacryloyl (GelMA), 55,57 methacrylated hyaluronic acid (MeHA), 5 8 , 5 9 poly(2-hydroxyethyl methacrylate) (PHEMA), 60,61 and poly(N-hydroxyethyl acrylamide) (pHEAA). 62,63 The porosity of all these gels can be varied by changing the monomer concentration and the monomer to cross-linker ratio. Some of these hydrogels, however, form under photo-cross-linking, 64 making them incompatible or inefficient with the DNA photocleavage-based release mechanism proposed here.…”

Section: Discussionmentioning

confidence: 99%

Fueling DNA Self-Assembly via Gel-Released Regulators

Osmanović

Klocke

et al. 2022

ACS Nano

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The development of responsive, multicomponent molecular materials requires means to physically separate yet easily couple distinct processes. Here we demonstrate methods to use molecules and reactions loaded into microliter-sized polyacrylamide hydrogels (mini-gels) to control the dynamic self-assembly of DNA nanotubes. We first characterize the UV-mediated release of DNA molecules from mini-gels, changing diffusion rates and minimizing spontaneous leakage of DNA. We then demonstrate that mini-gels can be used as compartments for storage and release of DNA that mediates the assembly or disassembly of DNA nanotubes in a one-pot process and that the speed of DNA release is controlled by the mini-gel porosity. With this approach, we achieve control of assembly and disassembly of nanotubes with distinct kinetics, including a finite delay that is obtained by loading distinct DNA regulators into distinct mini-gels. We finally show that mini-gels can also host and localize enzymatic reactions, by transcribing RNA regulators from synthetic genes loaded in the mini-gels, with diffusion of RNA to the aqueous phase resulting in the activation of self-assembly. Our experimental data are recapitulated by a mathematical model that describes the diffusion of DNA molecules from the gel phase to the aqueous phase in which they control self-assembly of nanotubes. Looking forward, DNA-loaded mini-gels may be further miniaturized and patterned to build more sophisticated storage compartments for use within multicomponent, complex biomolecular materials relevant for biomedical applications and artificial life.

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“…The addition of LMA micelles increases the detection range (0%–1823%) of the hydrogels. Furthermore, the addition of LMA increases the strength and density of the cross-linking point because of hydrophobic association, effectively prevents the propagation of cracks, and improves absorption of dissipated energy, increasing the strain range. − The ion channels formed by using AMPS and LiCl improve the conductivity and sensitivity of the AM-LMA-AMPS-LiCl (water/glycerol) hydrogel. The hydrogel exhibits high sensitivity (GF = 22.15 ± 2.86) because of the rapid migration of Li + between the negative SO 3 2– charge centers of zwitterions in the AM-LMA-AMPS-LiCl (water/glycerol) hydrogel network (Figure S1a).…”

Section: Introductionmentioning

confidence: 99%

Adhesive Ion-Conducting Hydrogel Strain Sensor with High Sensitivity, Long-Term Stability, and Extreme Temperature Tolerance

Zhang

Liang

Deng

et al. 2023

ACS Appl. Mater. Interfaces

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Ion-conducting hydrogels with excellent flexibility and ductility have great potential in human movements monitoring. However, some obstacles, including a small detection range, low sensitivity, low electrical conductivity, and poor stability under extreme conditions, impede their use as sensors. Herein, an ion-conducting hydrogel comprising acrylamide (AM), lauryl methacrylate (LMA), 2-acrylamido-2-methylpropanesulfonic acid (AMPS), and a water/glycerol binary solvent (named the AM-LMA-AMPS-LiCl (water/ glycerol) hydrogel) is designed, which exhibits an enlarged detection range of 0%−1823% and improved transparency. Notably, the ion channel constructed using AMPS and LiCl significantly improves the sensitivity (gauge factor = 22.15 ± 2.86) of the hydrogel. The water/glycerol binary solvent endows the hydrogel with electrical and mechanical stability under extreme conditions (70 and −80 °C). Furthermore, the AM-LMA-AMPS-LiCl (water/glycerol) hydrogel exhibits antifatigue properties for 10 cycles (0%−1000%) because of noncovalent interactions such as hydrophobic interactions and hydrogen bonding. The hydrogel can be used to monitor human movements such as joint bending and perceive subtle discrepancies such as different joint bending speeds and angles, showing its great potential application in human movement monitoring, electronic skin, and wearable devices.

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Tough and self-healing hydrogels based on transient crosslinking by nanoparticles

Abstract: In this investigation, a transient crosslinking was constructed to obtain a hydrogel with excellent mechanical and self-healing properties. Firstly, core-shell particles with hydrophilic amino groups were prepared by emulsion polymerization...

Cited by 6 publications

References 31 publications

Preparation of Ion2+-COS/SA Multifunctional Gel Films for Skin Wound Healing by an In Situ Spray Method

Preparation of Ion2+-COS/SA Multifunctional Gel Films for Skin Wound Healing by an In Situ Spray Method

Fueling DNA Self-Assembly via Gel-Released Regulators

Adhesive Ion-Conducting Hydrogel Strain Sensor with High Sensitivity, Long-Term Stability, and Extreme Temperature Tolerance

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