Total intravenous anaesthesia in horses using medetomidine and propofol

Bettschart‐Wolfensberger, Regula; Kalchofner, Karin; Neges, K; Kästner, Sabine; Fürst, Anton

doi:10.1111/j.1467-2995.2005.00202.x

Cited by 40 publications

(48 citation statements)

References 26 publications

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“…However, Mizuno et al 20 reported a cardiac index of 35 to 55 mL/kg/min by use of thermodilution during 2 hours of halothane anesthesia; also in another study by Young et al, 21 the calculated mean cardiac index value was 49 mL/kg/min by thermodilution during halothane anesthesia. 8,17 Primary factors affecting MAP are cardiac output and SVR. In addition, Mama et al 13 reported a cardiac index of 30 ± 6 mL/kg/min to 35 ± 10 mL/kg/min during 1 hour of ketamine TIVA and a cardiac index of 35 ± 8 mL/kg/min to 62 ± 15 mL/kg/min during 1 hour of propofol TIVA in horses.…”

Section: Discussionmentioning

confidence: 99%

“…12 The combination of propofol with analgesic agents could provide an alternative method for improving the quality and safety of anesthesia achieved in horses with propofol (ie, more-effective analgesia) and decreasing the total dose of drug required. 8,14,15 We previously reported that the combination of ketamine-medetomidine-propofol for TIVA provided better maintenance of surgical anesthesia for carotid artery translocation and decreased the requirement of propofol, compared with propofol infusion alone, in horses. 8,14,15 We previously reported that the combination of ketamine-medetomidine-propofol for TIVA provided better maintenance of surgical anesthesia for carotid artery translocation and decreased the requirement of propofol, compared with propofol infusion alone, in horses.…”

Section: Tivamentioning

confidence: 99%

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Evaluation of cardiovascular effects of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses

Umar

Yamashita²,

Kushiro³

et al. 2007

ajvr

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Section: Discussionmentioning

confidence: 99%

Section: Tivamentioning

confidence: 99%

Evaluation of cardiovascular effects of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses

Umar

Yamashita²,

Kushiro³

et al. 2007

ajvr

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“…Sevoflurane is a halogenated inhalant anesthetic with favorable physico-chemical and pharmacodynamic properties. On the other hand, findings during the infusion of injectable anesthetic drug combinations to horses suggest that cardiopulmonary parameters are better maintained during total intravenous anesthesia (TIVA) compared to inhalation anesthesia (Bettschart-Wolfensberger et al, 2001;Bettschart-Wolfensberger et al, 2005). Horses under sevoflurane anesthesia require less pharmacological support in the form of dobutamine than isoflurane-anesthetized horses to maintain adequate hemodynamic functions, which may be due to less severe suppression of the vasomotor tone.…”

Section: Resultsmentioning

confidence: 99%

The effect of preanesthetic administration of lactated Ringer solution on blood pressure in isoflurane-anesthetized horses

Bottegaro¹,

Vnuk²,

Smolec³

et al. 2011

Acta vet. (Beogr.)

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Hypotension induced by volatile agents is particularly notorious in horses and it is probably one of the major causes of the high anaesthetic risk in this species. In the present study we investigated the influence of 10 mL/kg lactated Ringer solution on the values of arterial blood pressure during the elective surgical procedure, administered right before the induction of anaesthesia. The goal was to establish if it was possible to lower the risk of hypotension development with this type of therapy. Nine horses divided in two groups were used in this study. All the horses were submitted to the same anesthetic regimen. The second group of horses received 10 mL/kg i.v. lactated Ringer solution in the 15 minutes time before the induction of anesthesia. The effect of lactated Ringer solution was noted at the beginning of anesthesia. Statistically significant differences among groups were noticed during the first measurement. The results indicate that the suggested method may provide a very simple way of supporting the cardiovascular system at least at the beginning of the surgical procedure

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“…Traditionally when dealing with patients undergoing anaesthesia, veterinary medicine pays attention to respiratory and heart rates, EKG parameters, tissue oxygen saturation and the CO 2 concentration in the expired gasses (ETCO 2 ), blood pressure and body temperature (Bettschart-Wolfensberger et al, 2005). The anatomy of reptiles makes continuous monitoring of these parameters rather difficult, and therefore relatively few detailed studies have been performed to date (Apelt, 1993;Bennett et al, 1998;Mosley et al, 2003a,b).…”

Section: Discussionmentioning

confidence: 99%

Blood profile in green iguanas after short-term anaesthesia with propofol

Knotková¹,

Knotek²,

Trnková³

et al. 2006

Vet. Med. - Czech

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Blood haematology and plasma chemistry profiles were examined in a group of ten 17 months-old green iguanas two minutes before propofol administration (10 mg/kg of body weight) and two minutes after recovery from anaesthesia. The induction time was very short (35.50 ± 22.54 s), the recovery time was 21.50 ± 7.44 minutes. At five and fifteen minutes of anaesthesia there was a considerable drop in the heart rate. The most marked drop, however, was noted during the tenth minute. Following the administration of propofol green iguanas showed marked changes in the respiratory frequency that were not accompanied by any changes in the levels of SpO2. RBC (1.06 ± 0.08 vs. 1.21 ± 0.06 1012/l) were decreased with a high significance (P < 0.01) two minutes after recovery from the propofol anaesthesia. At the same time there was a significant (P < 0.05) decrease of haemoglobin concentration (76.70 ± 13.39 vs. 83.73 ± 9.24 g/l) and PCV (0.34 ± 0.04 vs. 0.36 ± 0.04 l/l) as well as a significant (P < 0.05) increase of WBC (7.95 ± 3.38 vs. 5.20 ± 2.52 109/l), heterophils (3.14 ± 1.48 vs. 1.43 ± 0.43 109/l) and basophils (0.60 ± 0.53 vs. 0.23 ± 0.17 109/l). The following parameters increased two minutes after anaesthesia with a high significance (P < 0.01): plasma concentration of total protein (55.12 ± 5.94 vs. 49.02 ± 3.54 g/l), uric acid (231.07 ± 77.69 vs. 157.58 ± 60.58 µmol/l), AST (1.23 ± 0.52 vs. 0.67 ± 0.34 µkat/l), TAG (3.37 ± 1.11 vs. 1.48 ± 0.78 mmol/l), phosphorus (2.29 ± 0.38 vs. 1.85 ± 0.35 mmol/l). The increase in plasma calcium levels (3.51 ± 0.11 vs. 3.21 ± 0.23 mmol/l) was significant at the level of P < 0.05. All the measured values were within the reference range of healthy green iguanas.

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Total intravenous anaesthesia in horses using medetomidine and propofol

Cited by 40 publications

References 26 publications

Evaluation of cardiovascular effects of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses

Evaluation of cardiovascular effects of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses

The effect of preanesthetic administration of lactated Ringer solution on blood pressure in isoflurane-anesthetized horses

Blood profile in green iguanas after short-term anaesthesia with propofol

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