Total Antioxidant Status, Vitamins A, C and β-carotene Levels of Children with P. falciparum Infection in 
 University of Calabar Teaching Hospital (UCTH), Calabar

Akpotuzor, JO; Udoh, A. E.; Etukudo, Maisie Henrietta

doi:10.3923/pjn.2007.485.489

Cited by 15 publications

(24 citation statements)

References 7 publications

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“…This finding is consistent with previous reports in Nigeria which found P. falciparum as the predominant species responsible for malarial infection in Nigeria 10,11,30,31. Mapping the global distribution of malaria motivated by a need to define populations at risk for appropriate resource allocation, and to provide a robust framework for evaluating its global economic impact, has shown that malarial infection particularly caused by P. falciparum has been geographically restricted and remains entrenched in poor areas of the world, particularly in sub-Saharan Africa 32…”

Section: Discussionsupporting

confidence: 93%

“…A significantly lower level of vitamin A was seen in severe malaria-parasitized children compared with the levels of both mild and moderate malarial infections 14,16,17. The low concentration of vitamin A seen in malaria-infected children in this study may be attributable to inflammatory response27 and redistribution of vitamin A into extra vascular spaces to allow for increased bioavailability to the tissues 28…”

Section: Discussionmentioning

confidence: 80%

“…The mechanism that might affect the pathogenesis and antioxidant status of children with malaria is thought to be the production of excess free radicals, which induces lipid peroxidation and cell damage. In children, micronutrient status has been shown to influence resistance to several infectious diseases, including measles, diarrhea, and respiratory diseases 8–11. A randomized trial in Papua New Guinea has shown that periodic vitamin A supplementation could reduce the incidence of febrile episodes and parasitemia due to Plasmodium falciparum 12.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant vitamin levels among preschool children with uncomplicated Plasmodium falciparum malaria in Sokoto, Nigeria

Aghedo¹,

Shehu²,

Umar³

et al. 2013

JMDH

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ObjectiveTo assess antioxidant vitamin levels among preschool children with plasmodium malarial infection.MethodsWe assessed antioxidant vitamin levels by using a standard procedure in 130 malaria-parasitized preschool children. Packed cell volume and parasite density were also evaluated. Forty healthy age- and gender-matched nonparasitized children were included as controls.ResultsPlasmodium falciparum was the causative species in all subjects. The mean malaria parasitemia was 4529.45 ± 1237.5/μL. The mean antioxidant concentrations for vitamins A, C, and E among plasmodium-parasitized subjects were 33.15 ± 1.79 μg/dL, 0.51 ± 0.02 mg/dL, and 0.61 ± 0.02 mg/dL, respectively. The mean concentrations of vitamins A, C, and E among the non-malaria-parasitized controls were 69.72 ± 1.71 μg/dL, 1.25 ± 0.04 mg/dL, and 1.31 ± 0.04 mg/dL respectively. We observed that the mean antioxidant concentrations of vitamins A, C, and E were significantly lower among plasmodium-parasitized subjects compared with non-parasitized controls (P = 0.01). Malaria parasitemia correlated negatively with antioxidant concentrations and packed cell volume (r = −0.736 and −0.723, P = 0.001). We observed that the higher the level of parasitemia, the lower the antioxidant concentration.ConclusionOur study has shown that the antioxidant levels in plasmodium-parasitized children in the North-West of Nigeria are low and that the more severe the malarial infection, the lower the antioxidant level and the packed cell volume. One key strategic intervention is the provision of early diagnosis and prompt effective treatment. We recommend that malaria-parasitized children, particularly those in the North-West of Nigeria, be placed routinely on antioxidant vitamins to manage the micronutrient deficiencies seen in these children. There is also the need for the promotion of insecticide-treated bed nets, intermittent preventive treatment, and effective case management of malarial illness among children.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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Antioxidant vitamin levels among preschool children with uncomplicated Plasmodium falciparum malaria in Sokoto, Nigeria

Aghedo¹,

Shehu²,

Umar³

et al. 2013

JMDH

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“…One of the consequences of oxidative stress is the development of malarial anaemia 13,14 . Thus the overall antioxidant status will give more relevant biological information compared to that obtained by the measurements of individual components 15 . In Caucasians, a reference range of 1.30 -1.78 mmol/L has been reported 16 .…”

Section: Introductionmentioning

confidence: 99%

Serum Level of Antioxidant Vitamins (Vitamin A, C and E) in ,i>Plasmodium falciparum</i> Malaria Infected Children in Owerri, Eastern Nigeria

Ekeanyanwu¹,

Achuka²,

Akpoilih³

2010

Biokemistri

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The levels of antioxidant vitamins were estimated in Plasmodium falciparum malaria infected children. Forty-three children with P.falciparum infection were selected based on the clinical symptoms. Twenty-two apparently healthy children with no malaria parasitaemia were included as the control subjects. P.falciparum parasitaemia and serum levels of the antioxidant vitamins (vitamin A, C and E) were determined using standard procedures. It was observed that all parameters measured were significantly lower in malaria infected children when compared with the respective control values. The relationship between malaria parasitaemia and serum concentration of vitamin E were positively correlated (r= 0.42), but vitamin A (r=-0.05) and C (-0.06) were negatively correlated. Children within 0-5 years of age had higher malarial parasitaemia (7379.82 ± 918 99/µL) than those between 6-12 years of age (5026.19 ± 1514.58/µL), and these children had lower concentrations of vitamin A (21.27 ± 8.68 µg/dL), C (0.45 ± 0.19 mg/dl) and E (0.69 ± 0.22 mg/dL) when compared with children between 6-12 years (vitamin A = 25.19 ± 8.12 µg/dL, vitamin C = 0.53 ± 0.16 mg/ dL and vitamin E = 0.86 ± 0.41 mg/ dL). Results suggest that in Owerri, Eastern Nigeria, the degree of malaria parasitaemia in especially children between 0-5 years could comprise immunity (as judged by the correlation) and reduce serum antioxidant vitamin levels. Health care providers should recognize these effects in planning malarial treatment and control programs. Changes in serum antioxidant levels during post-treatment periods should be investigated and documented.

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“…Hal ini membuktikan bahwa mikronutrien tersebut dipakai dalam menghadapi peningkatan parasitemia. 18,19 Rendahnya kadar antioksidan tersebut pada anak yang terinfeksi ini kemungkinan disebabkan sebagian oleh peningkatan utilisasi atau peningkatan destruksi pada malaria. 20 Pemberian antioksidan seperti asam L askorbat sangat direkomendasikan pada malaria karena didapatkan penurunan kadar zat tersebut, apalagi kalau malaria tersebut mendapat terapi artemisnin yang juga mempunyai andil dalam hal peningkatan kadar radikal bebas yang berarti akan mempunyai andil pula dalam menurunkan kadar antioksidan termasuk asam L askorbat.…”

Section: Pembahasanunclassified

Asam L Askorbat Meningkatkan Viabilitas HUVEC dalam Kultur P. falciparum yang Diinkubasi dengan Artemisinin Bergantung Konsentrasi

Tjahjani¹,

Achmad²,

Syafruddin³

2011

mkb

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AbstrakArtemisinin, antimalaria yang sangat ampuh terhadap parasit multiresisten, bekerja melalui produksi radikal bebas. Oleh karena terjadinya alur permeasi baru pada membran eritrosit yang terparasitisasi, asam L askorbat, suatu antioksidan hidrofilik, diharapkan tidak menembus membran tersebut sehingga tidak mempengaruhi daya antimalaria artemisinin melainkan hanya mempengaruhi sel inang di luar eritrosit yang terparasitisasi. Artemisinin via overproduction of free radical acts as a potent drug against multi-drug resistant Plasmodium. Because of new permeation pathway evidence at parasitized red blood cell membrane, L ascorbic acid as hydrophilic antioxidant hopefully can't penetrate the membrane so that it won't interfere the artemisinin antimalarial effect rather it protects the host cell out of parasitized erythrocytes. The aim of this study was to determine its effect against human umbilical vein endothelial cell (HUVEC) viability, glutathione sulfa-hydryl (GSH), and malondialdehyde (MDA) concentration in Plasmodium falciparum culture treated with artemisinin. This experiment was conducted at Eijkman Insitute for Molecular Biology, Jakarta from January 2007 to January 2008. Plasmodium falciparum 3D7 strain culture was incubated with IC 50 of artemisinin and a wide concentration range of L ascorbic acid for 24 hours in a candle jar at 37 o C incubator. GSH and MDA concentration were measured from the supernatant using spectrophotometer. HUVEC viability was measured in P. falciparum-HUVEC co-cultivation incubated with artemisinin IC 50 and L ascorbic acid. The result was examined and analyzed using analysis of variance (ANOVA) and Tukey honestly significant difference (HSD)/Scheffe. It showed that 20 µM and 100 µM L ascorbic acid raised the HUVEC viability. It was concluded that L ascorbic acid concentration dependently increases HUVEC viability in P. falciparum culture incubated with artemisinin. [MKB. 2011;43(2):66-71].

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Total Antioxidant Status, Vitamins A, C and β-carotene Levels of Children with P. falciparum Infection in University of Calabar Teaching Hospital (UCTH), Calabar

Cited by 15 publications

References 7 publications

Antioxidant vitamin levels among preschool children with uncomplicated Plasmodium falciparum malaria in Sokoto, Nigeria

Antioxidant vitamin levels among preschool children with uncomplicated Plasmodium falciparum malaria in Sokoto, Nigeria

Serum Level of Antioxidant Vitamins (Vitamin A, C and E) in ,i>Plasmodium falciparum</i> Malaria Infected Children in Owerri, Eastern Nigeria

Asam L Askorbat Meningkatkan Viabilitas HUVEC dalam Kultur P. falciparum yang Diinkubasi dengan Artemisinin Bergantung Konsentrasi

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