The result therefore suggests that the seed extract is potentially safe.

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This research was aimed to investigate the anti micranthum on blood glucose levels and oxidative stress biomarkers such as malondaldehyde, superoxide dismutase, catalase and glutathione peroxidase on alloxan induced Diabetes in Wistar rats. Diabetes was induced using alloxan (150 mg/kg i.p). The rats w rats each. Group 1 served as the diabetic control, Group 2 received 2 mg/kg glibenclamide, while Groups 3, 4 and 5 were orally administered 100, 200 and 400 mg/kg body weight of ethanol leaf extract of Combretum micranthum tail artery and the serum was used to determine the oxidative stress biomarkers (malondaldehyde, superoxide dismutase, catalase and glutathione peroxidase).There was a significant (p in the blood glucose when compared with the diabetic control. Also there was a significant (p<0.05) decrease in the oxidative stress biomarkers when compared with the diabetic control. The preliminary phytochemical screening of the of the e glycosides, alkaloids ,terpenoids and resins. The LD conclusion Combretum micranthum reduce blood glucose levels, reactive oxygen free radicals and improved the activities of the antioxidant enzymes.

The levels of antioxidant vitamins were estimated in Plasmodium falciparum malaria infected children. Forty-three children with P.falciparum infection were selected based on the clinical symptoms. Twenty-two apparently healthy children with no malaria parasitaemia were included as the control subjects. P.falciparum parasitaemia and serum levels of the antioxidant vitamins (vitamin A, C and E) were determined using standard procedures. It was observed that all parameters measured were significantly lower in malaria infected children when compared with the respective control values. The relationship between malaria parasitaemia and serum concentration of vitamin E were positively correlated (r= 0.42), but vitamin A (r=-0.05) and C (-0.06) were negatively correlated. Children within 0-5 years of age had higher malarial parasitaemia (7379.82 ± 918 99/µL) than those between 6-12 years of age (5026.19 ± 1514.58/µL), and these children had lower concentrations of vitamin A (21.27 ± 8.68 µg/dL), C (0.45 ± 0.19 mg/dl) and E (0.69 ± 0.22 mg/dL) when compared with children between 6-12 years (vitamin A = 25.19 ± 8.12 µg/dL, vitamin C = 0.53 ± 0.16 mg/ dL and vitamin E = 0.86 ± 0.41 mg/ dL). Results suggest that in Owerri, Eastern Nigeria, the degree of malaria parasitaemia in especially children between 0-5 years could comprise immunity (as judged by the correlation) and reduce serum antioxidant vitamin levels. Health care providers should recognize these effects in planning malarial treatment and control programs. Changes in serum antioxidant levels during post-treatment periods should be investigated and documented.