Torque Teno Virus (TTV) as a Risk Factor in Hemodialysis Process in Kirkuk

Wahid, Nuha M.; Saadoon, Israa Hashim

doi:10.5958/0973-9130.2019.00502.4

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Interestingly, both the total eukaryotic abundance and relative abundance of viruses of the Anelloviridae family were higher in hemodialysis patients ( Figure 3 and Figure 4 , respectively). Previous studies have linked TTV ( Alphatorquevirus ) presence to blood transfusion frequency and time under treatment in hemodialysis patients [ 62 ]. Similar conclusions were drawn in Romanian individuals [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients

Thijssen

Khamisipour

Maleki

et al. 2023

Viruses

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Blood transfusion safety is an essential element of public health. Current blood screening strategies rely on targeted techniques that could miss unknown or unexpected pathogens. Recent studies have demonstrated the presence of a viral community (virobiota/virome) in the blood of healthy individuals. Here, we characterized the blood virome in patients frequently exposed to blood transfusion by using Illumina metagenomic sequencing. The virome of these patients was compared to viruses present in healthy blood donors. A total number of 155 beta-thalassemia, 149 hemodialysis, and 100 healthy blood donors were pooled with five samples per pool. Members of the Anelloviridae and Flaviviridae family were most frequently observed. Interestingly, samples of healthy blood donors harbored traces of potentially pathogenic viruses, including adeno-, rota-, and Merkel cell polyomavirus. Viruses of the Anelloviridae family were most abundant in the blood of hemodialysis patients and displayed a higher anellovirus richness. Pegiviruses (Flaviviridae) were only observed in patient populations. An overall trend of higher eukaryotic read abundance in both patient groups was observed. This might be associated with increased exposure through blood transfusion. Overall, the findings in this study demonstrated the presence of various viruses in the blood of Iranian multiple-transfused patients and healthy blood donors.

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Section: Discussionmentioning

confidence: 99%

Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients

Thijssen

Khamisipour

Maleki

et al. 2023

Viruses

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“…Previous studies have demonstrated varying grades of association between TTV DNA levels and immune de ciencies related to age, chronic infections and cancer (11,12). Several Iraqi studies were conducted in different cities and reported different percentages such as that of 2% among patients with haemoglobinopathies and haematological malignancies in Basrah Governorate (13), 15% of hemodiyalsis patients had TTV DNA in Kirkuk (14), recently, a high rate (43.33%) in saliva and 40% in tumor biopsy) in oral carcinoma patients than in controls (18.33% in saliva ) (15). To the best of our Knowledge, there is no Iraqi study among women with urinary tract infection in Diyala Governorate, thus this study aimed to detect Torque Teno Virus among women with urinary tract infections in Diyala Governorate.…”

Section: Introductionmentioning

confidence: 99%

Genotyping of Torque Teno Virus among Women with Urinary Tract Infection in Diyala Governorate

Kaleefah

2023

Preprint

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Introduction: Urinary tract infections are a persistent global problem; several types of pathogens associated with this disease Torque Teno Virus is a possible cause that can affect all ages and affect women more than men due to anatomy and physiological functions. Objectives: To determine the infection rate and genotypes of Torque Teno Virus among women with urinary tract infection and study the correlation between Torque Teno Virus infection and different parameters. Methods: A cross-sectional study was performed using data obtained from women with urinary tract infections (50 pregnant women and 50 non-pregnant women). Urine samples were collected for microscopic and macroscopic examination, bacterial culture, DNA extraction, followed by amplification with specific primers by a nested polymerase chain reaction for phylogenic analysis. Results: Out of 100 samples, eight samples were positive for Torque Teno Virus (8%). The infection rate of Torque Teno Virus was more common (75%) in the age group (31-47) years with statistical significance. Three cases (37.5%) of Staphylococcus aureus and 2 cases (25%) of each of Escherichia coli and Proteus mirabilis, and 1(12.5%) Enterococcus fecalis showed co-infection with positive Torque Teno Virus cases. The phylogenetic analysis results for Torque Teno Virus DNA isolated from urine samples revealed that all local isolates (8 isolates) belong to type 1 and 2. According to the closest, the phylogenetic tree results analysis showed the local isolate (No. 6 ) clustered with the reference isolates (Egypt, USA, England, Australia and Saudi Arabia). Isolate (No.1) showed was close to Italian and Brazilian isolates, while isolates number (2 and 5), (3 and 7), and (4 and 8) are very closely related to each other and closed to isolates from Iran. Conclusion: The genotyping analysis of Torque Teno Virus among women with UTI in Diyala Governorate found that all isolates in the studied group belong to TTV genotypes 1 and 2, local isolate (No. 6) was close to isolates from different regions such as Egypt, USA, England, Australia and Saudi Arabia, local isolate (No. 1) was close to Italian and Brazilian isolates. Moreover, the other six isolates were closed to Iranian isolates.

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Detection of Torque Teno Virus Antigen and Associated Risk Factors Among Hemodialysis Patients

2022

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The aim: To determine the prevalence of TTV in patients undergoing hemodialysis and to evaluate the possible risk factors. Materials and methods: This study was conducted in 93 patients, attending hemodialysis unit at AL-Imammain AL-Kadhimain Medical City Hospital for a period from November 2020 to March 2021. The demographic and clinical characteristics including age, sex, underling medical condition, hepatitis B and C status and laboratory tests such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline Phosphatase (ALP) and total serum bilirubin (TSB) were obtained from the record of the patients in hemodialysis unit in the hospital. Direct detection of TTV-Ag was done by enzyme linked immunosorbent assay (ELISA). Results: TTV-Ag was detected in 38 out of 93 (40.9%) hemodialysis patients. Demographic, clinical and risk factors i.e. sex, age, history of diabetes, history of hypertension, history of blood transfusion, number of blood transfusion, the hemodialysis duration, history of surgery and liver enzymes levels did not show significant relation (P>0.05). Conclusions: This study showed high prevalence of Torque Teno virus in hemodialysis patients, however, TTV did not play a role in liver injury among these patients.

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Torque Teno Virus (TTV) as a Risk Factor in Hemodialysis Process in Kirkuk

Cited by 3 publications

References 11 publications

Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients

Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients

Genotyping of Torque Teno Virus among Women with Urinary Tract Infection in Diyala Governorate

Detection of Torque Teno Virus Antigen and Associated Risk Factors Among Hemodialysis Patients

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