Topical treatment of cutaneous leishmaniasis lesions using quercetin/ Artemisia-capped silver nanoparticles ointment: Modulation of inflammatory response

Alemzadeh, Effat; Karamian, Mehdi; Abedi, Farshid; Hanafi‐Bojd, Mohammad Yahya

doi:10.1016/j.actatropica.2022.106325

Cited by 9 publications

(8 citation statements)

References 49 publications

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“…Reductions in both lesion size and inflammatory responses, along with acceleration of wound healing, were observed in Que-treated animals infected with L. major [40][41][42]94]. In one study, the abundance of apoptotic neutrophils containing apoptotic amastigotes in Que-treated mice was noticed [10], suggesting that exposure to Que could markedly abrogate L. major-induced apoptosis delay.…”

Section: 4mentioning

confidence: 99%

Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues

Memariani,

Ghasemian

2024

BioMed Research International

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Despite tremendous advances in the prevention and treatment of infectious diseases, only few antiparasitic drugs have been developed to date. Protozoan infections such as malaria, leishmaniasis, and trypanosomiasis continue to exact an enormous toll on public health worldwide, underscoring the need to discover novel antiprotozoan drugs. Recently, there has been an explosion of research into the antiprotozoan properties of quercetin, one of the most abundant flavonoids in the human diet. In this review, we tried to consolidate the current knowledge on the antiprotozoal effects of quercetin and to provide the most fruitful avenues for future research. Quercetin exerts potent antiprotozoan activity against a broad spectrum of pathogens such as Leishmania spp., Trypanosoma spp., Plasmodium spp., Cryptosporidium spp., Trichomonas spp., and Toxoplasma gondii. In addition to its immunomodulatory roles, quercetin disrupts mitochondrial function, induces apoptotic/necrotic cell death, impairs iron uptake, inhibits multiple enzymes involved in fatty acid synthesis and the glycolytic pathways, suppresses the activity of DNA topoisomerases, and downregulates the expression of various heat shock proteins in these pathogens. In vivo studies also show that quercetin is effective in reducing parasitic loads, histopathological damage, and mortality in animals. Future research should focus on designing effective drug delivery systems to increase the oral bioavailability of quercetin. Incorporating quercetin into various nanocarrier systems would be a promising approach to manage localized cutaneous infections. Nevertheless, clinical trials are needed to validate the efficacy of quercetin in treating various protozoan infections.

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Section: 4mentioning

confidence: 99%

Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues

Memariani,

Ghasemian

2024

BioMed Research International

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“…Hence, the incorporation of QUE into these systems may result in synergistic expression of their common anti-inflammatory and antioxidant properties. In two recent studies, the combination of QUE with artemisia and curcumin in two different silver N systems is proposed for the management of inflammation [ 178 , 179 ]. Namely, the artemisia/QUE NPs ointment was tested in vivo as wound healing agent in mice infected with cutaneous leishmaniasis.…”

Section: Que Nanosystemsmentioning

confidence: 99%

“…The NPs had a mean diameter size of 113.9 nm, and they were characterized by stability (−23.89 mV zeta potential). The 21-day topical treatment led to faster wound healing and less intense inflammatory response, as depicted in the inflammatory cells number [ 178 ].…”

Section: Que Nanosystemsmentioning

confidence: 99%

Recent Advances in Nanoformulations for Quercetin Delivery

et al. 2023

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Quercetin (QUE) is a flavonol that has recently received great attention from the research community due to its important pharmacological properties. However, QUE’s low solubility and extended first-pass metabolism limit its oral administration. This review aims to present the potential of various nanoformulations in the development of QUE dosage forms for bioavailability enhancement. Advanced drug delivery nanosystems can be used for more efficient encapsulation, targeting, and controlled release of QUE. An overview of the primary nanosystem categories, formulation processes, and characterization techniques are described. In particular, lipid-based nanocarriers, such as liposomes, nanostructured-lipid carries, and solid-lipid nanoparticles, are widely used to improve QUE’s oral absorption and targeting, increase its antioxidant activity, and ensure sustained release. Moreover, polymer-based nanocarriers exhibit unique properties for the improvement of the Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADME(T)) profile. Namely, micelles and hydrogels composed of natural or synthetic polymers have been applied in QUE formulations. Furthermore, cyclodextrin, niosomes, and nanoemulsions are proposed as formulation alternatives for administration via different routes. This comprehensive review provides insight into the role of advanced drug delivery nanosystems for the formulation and delivery of QUE.

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“…In comparison, the use of green materials such as bacteria, fungi, proteins, polypeptides, algal extracts, and plant extracts as reducing agents in the synthesis of AgNPs is cost efective and ecofriendly [24][25][26]. Green synthesis of AgNPs based on plant extracts containing phytochemicals such as terpenoids, favonoids, phenolics, aldehydes, carboxylic acids, and enzymes can act as a reducing and stabilizing agent as well as a capping agent in the biosynthesis of AgNPs [26][27][28][29]. Te antimicrobial and antiprotozoal efects of silver nanoparticles depend on their ability to produce reactive oxygen species (ROS), which play an important role in killing pathogenic microbes [30,31].…”

Section: Introductionmentioning

confidence: 99%

Topically Applied Luteolin /Quercetin-Capped Silver Nanoparticle Ointment as Antileishmanial Composite: Acceleration Wound Healing in BALB/c Mice

Ebrahimzadeh

Karamian

Abedi

et al. 2023

Advances in Materials Science and Engineering

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Cutaneous leishmaniasis is a major health problem in several parts of the world. However, existing drugs have various therapeutic effects on different Leishmania species and also cause many side effects. This study focuses on the use of the aqueous extract of quercetin in producing silver nanoparticles for the experimental treatment of cutaneous leishmaniasis in laboratory mice. Silver nanoparticles (AgNPs) were synthesized using quercetin and characterized by UV-Vis spectroscopy, DLS, FTIR, and FESEM. We investigated the antileishmanial activity of green synthesized AgNPs in vitro and in vivo. Synthesized AgNPs from quercetin macromolecules showed promising antileishmanial activity at an IC50 of 125 μg/ml against promastigotes in vitro. In the in vivo study, L. major-infected BALB/c mice were treated topically with luteolin/quercetin-capped silver nanoparticle (AgNPQct) ointment for 21 consecutive days. As a result, this ointment reduced the inflammatory response compared to the untreated group ( p < 0.05). The size of lesions in the luteolin/AgNPQct group showed a slight increase compared to other groups ( p < 0.01). Biogenic silver nanoparticles along with the luteolin macromolecule can be an effective and reliable candidate for the design of antileishmanial drugs in the future.

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Topical treatment of cutaneous leishmaniasis lesions using quercetin/ Artemisia-capped silver nanoparticles ointment: Modulation of inflammatory response

Cited by 9 publications

References 49 publications

Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues

Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues

Recent Advances in Nanoformulations for Quercetin Delivery

Topically Applied Luteolin /Quercetin-Capped Silver Nanoparticle Ointment as Antileishmanial Composite: Acceleration Wound Healing in BALB/c Mice

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