Recent Advances in Nanoformulations for Quercetin Delivery

Abstract

Quercetin (QUE) is a flavonol that has recently received great attention from the research community due to its important pharmacological properties. However, QUE’s low solubility and extended first-pass metabolism limit its oral administration. This review aims to present the potential of various nanoformulations in the development of QUE dosage forms for bioavailability enhancement. Advanced drug delivery nanosystems can be used for more efficient encapsulation, targeting, and controlled release of QUE. An overview of the primary nanosystem categories, formulation processes, and characterization techniques are described. In particular, lipid-based nanocarriers, such as liposomes, nanostructured-lipid carries, and solid-lipid nanoparticles, are widely used to improve QUE’s oral absorption and targeting, increase its antioxidant activity, and ensure sustained release. Moreover, polymer-based nanocarriers exhibit unique properties for the improvement of the Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADME(T)) profile. Namely, micelles and hydrogels composed of natural or synthetic polymers have been applied in QUE formulations. Furthermore, cyclodextrin, niosomes, and nanoemulsions are proposed as formulation alternatives for administration via different routes. This comprehensive review provides insight into the role of advanced drug delivery nanosystems for the formulation and delivery of QUE.

To Investigate the Mechanism of Qinpi Tongfeng Formula in Treating Acute Gouty Arthritis by UHPLC-Q-Orbitrap-MS, Network Pharmacology and Experimental Validation

“… 38 Studies have indicated that quercetin is soluble in alcohol and lipids, suggesting that quercetin may need to be administered through modified dosage forms, such as the use of nanocarrier systems, to improve its effectiveness and bioavailability in the treatment of arthritis and gouty arthritis. 39 Research findings indicate that eburicoic acid exhibits properties of an antioxidant and possesses anti-inflammatory effects. 40 Eburicoic acid has an obvious anti-inflammatory effect by inhibiting the activation of PI3K/Akt/NF-κB signaling pathway, 41 furthermore, it possesses the ability to suppress xanthine oxidase activity, leading to low uric acid levels.…”

Capparis cartilaginea decne (capparaceae): isolation of flavonoids by high-speed countercurrent chromatography and their anti-inflammatory evaluation

“…A suitable approach that could overcome those problems is using nanocarriers that, targeting inflammation, allow the release of the drug locally, reducing side effects. There are multiple investigations where not only ‘classical synthetic drugs’ but “natural products” have been formulated using nanotechnology to treat different conditions such as cancer, cardiovascular diseases, or inflammation ( Hesari et al, 2021 ; An et al, 2023 ; Hussain et al, 2023 ; Tomou et al, 2023 ; Zandieh et al, 2023 ).…”

Effect of liposomal complexes of quercetin-rich flavonoids from French Marigold (Tagetes patula L.) on Jurkat cell viability

“…Despite their healthful properties, ingesting phenolic compounds in orally does not provide a sufficient concentration for systemic therapeutic effects due to their low solubility in water, poor absorption, and fast metabolism [9]. This problem has been solved by creating various composite pharmaceuticals from phenolic compounds using different methods (cyclodextrin coatings, simple emulsions, lipid nanoparticles, or liposomes [10][11][12][13]) to ensure the stabilization of polyphenols. The genus Tagetes (Asteraceae) is originally from the Americas, but some of its species, such as Tagetes erecta and Tagetes patula, were introduced to European countries from India and North Africa in the 16th century and became naturalized there [14].…”