Topical NSAIDs for acute pain in adults

Abstract

Topical NSAIDs can provide good levels of pain relief, without the systemic adverse events associated with oral NSAIDs, when used to treat acute musculoskeletal conditions.

Treatment of osteoarthritis: A focus on nimesulide

“…Важным преимуществом локальных НПВП является достижение высокой концентрации активного вещества в пораженной области при более низкой его концентрации в плазме крови, что дает возможность значительно умень-шить риск развития системных нежелательных явлений [76]. Наиболее удобной формой для противовоспалитель-ной локальной терапии является гель.…”

Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries

“…However, there is still debate on these potential advantages as there is continuous lack of significant positive results 2–4. A Cochrane review update was recently carried out to assess the effect of topical NSAIDs used for acute musculoskeletal pain in adults 5. This review aimed to strengthen conclusions on the efficacy and safety of topically applied NSAIDs in acute musculoskeletal pain in adults, adding recently published studies to the previous search.…”

Controversies and advances in non-steroidal anti-inflammatory drug (NSAID) analgesia in chronic pain management

“…A Cochrane review in 2010 of 47 double blinded RCTs showed that topical diclofenac, ibuprofen, ketoprofen, and piroxicam are significantly more effective and as safe as topical placebo in the treatment of acute musculoskeletal pain 27. The review did not address the safety of chronic use.…”