Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries

Vuurberg, Gwendolyn; Kerkhoffs, Gino M. M. J.

doi:10.1136/ebmed-2016-110406

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…A reduction in the release of free oxygen radicals, which occurs under the influence of diclofenac sodium, can also contribute to a decrease in the inflammatory process activity [ 14 ]. In addition to pronounced anti-inflammatory activity, diclofenac sodium has complex effects on various mechanisms of pain perception, providing effective suppression of pain syndromes of various aetiologies, as well as central and peripheral antinociceptive effects [ 15 , 16 ]. Topical diclofenac may be preferred over oral NSAIDs, especially for older patients and those who have comorbid conditions and/or risk factors for various systemic adverse events associated with oral NSAIDs, particularly when used at high doses or for long durations [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Two-Phase Gel Formulations for Enhanced Delivery of Active Ingredients: Sodium Diclofenac and Camphor

Kasparaviciene,

Maslii,

Herbina

et al. 2024

Pharmaceutics

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The formulation of biphasic gels as potential semi-solid carriers for hydrophilic and lipophilic active substances is promising for the development of pharmaceutical preparations. The aim of this study was to design a stable bigel composition and to determine the influence of the organogel/hydrogel ratio on the gel’s physical-chemical and structural-mechanical properties. The investigated compositions of organogel/hydrogel remained stable at ratios ranging from 5/95 to 40/60. After texture and microstructure analysis, bigels with 20/80 and 25/75 ratios were selected as carriers for the active ingredients, sodium diclofenac and camphor, for use as topical preparations for the treatment of muscle-joint inflammation and pain. Although other researchers have published data on the preparation and evaluation of bigels, there are no scientific results on the development of a two-phase gel with our proposed combination of APIs. Sodium diclofenac release was found to be higher when combined with camphor, which revealed the advantages of the biphasic formulation. The pseudoplastic behavior, thixotropy, and thermal stability of flow of the studied bigel samples was investigated by rheological analysis. Ongoing stability studies confirmed the minimal 6-month period.

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Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Two-Phase Gel Formulations for Enhanced Delivery of Active Ingredients: Sodium Diclofenac and Camphor

Kasparaviciene,

Maslii,

Herbina

et al. 2024

Pharmaceutics

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Morniflumate in the treatment of upper airways affections in adults: a review and meta-analysis

Paleari

Cavalieri

2022

Minerva Med

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The effect of topical triturate glyceryl in the treatment of tennis elbow: a randomized clinical trial

et al. 2020

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Background: Tennis elbow (TE), as a lateral epicondylitis (LE), is a chronic inflammatory and degenerative tendon disease that causes pain in the outer part of the elbow. This study aimed to evaluate the efficacy of topical Trinitrate Glyceryl (GTN) in the treatment of patients with TE. Materials and methods: In this double-blind clinical trial, 90 patients with TE, referred to Orthopedic and Rheumatology Clinics of Bou-Ali Hospital in Tehran from October 2012 until January 2014, have been studied. They were randomly divided into 2 groups of 45 subjects (treatment and control group). Intervention group received dermal patches and GTN-containing drop, and the control group received dermal patches and liquid paraffin-containing drop (placebo). Results: Significant improvement in pain and tenderness was observed after 2, 4 and 6 weeks in intervention group compared to control group (p<0.05). Conclusion:Based on the findings of this study, GTN has a significant effect on pain relief and tenderness in patients with TE.

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Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries

Cited by 3 publications

References 6 publications

Development and Evaluation of Two-Phase Gel Formulations for Enhanced Delivery of Active Ingredients: Sodium Diclofenac and Camphor

Development and Evaluation of Two-Phase Gel Formulations for Enhanced Delivery of Active Ingredients: Sodium Diclofenac and Camphor

Morniflumate in the treatment of upper airways affections in adults: a review and meta-analysis

The effect of topical triturate glyceryl in the treatment of tennis elbow: a randomized clinical trial

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