Topical cyclosporine in the treatment of vulvar lichen sclerosus: clinical, histologic, and immunohistochemical findings

Carli, P.

doi:10.1001/archderm.128.11.1548

Cited by 13 publications

(7 citation statements)

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“…Less commonly used measures of disease severity included the description of histological features such as epidermal atrophy, hyperkeratosis, and dermal inflammation 14 , 25 , 48 – 53 and the measurement of various inflammatory marks with immunohistochemical staining. 14 , 20 , 21 , 26 , 46 , 48 , 51 , 54 – 58 Finally, some studies focused on the quality-of-life effects of this disease as well as interference with sexual functioning. 18 , 22 , 35 , 48 , 59 , 60 …”

Section: Resultsmentioning

confidence: 99%

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Sheinis

Selk

2018

J Low Genit Tract Dis

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Section: Resultsmentioning

confidence: 99%

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Sheinis

Selk

2018

J Low Genit Tract Dis

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“…After 8 weeks treatment with ciclosporin a significant improvement of symptoms was reported by one patient, three reported slight improvement, one no changes. Complete recovery was not found in any patient (Carli ). Based on the limited data, the therapeutic efficacy of topical ciclosporin cannot be determined (Echalal 1995, Chi ).…”

Section: Topical Calcineurin Inhibitors/non‐antibiotic Macrolidesmentioning

confidence: 87%

Evidence‐based (S3) Guideline on (anogenital) Lichen sclerosus

Kirtschig

Becker²,

Günthert

et al. 2015

Acad Dermatol Venereol

240

155

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Lichen sclerosus (LS) is an inflammatory skin disease that usually involves the anogenital area. All patients with symptoms or signs suspicious of lichen sclerosus should be seen at least once initially by a physician with a special interest in the disease in order to avoid delay in diagnosis, as early treatment may cure the disease in some and reduce or prevent scarring. The diagnosis is made clinically in most cases. Biopsies should only be performed under certain circumstances. The gold standard for treatment remains potent to very potent topical steroids; however, mild and moderate disease in boys and men may be cured by circumcision. Certain triggers should be avoided.

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“…Topical retinoids have also been tried, but significant cutaneous irritation following application on the vulvar area creates an important limitation to its use (69). A study using 10% topical cyclosporine on five LS patients failed to reveal any clinical or histological benefit to its application (70). Photodynamic therapy using a topical application of a 20% solution of 5‐aminolevulinic acid up to three cycles of treatment showed relief of symptoms, but minor or no improvement of the disease process (71).…”

Section: Treatmentmentioning

confidence: 99%

Lichen sclerosus: a review and practical approach

2004

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Lichen sclerosus (LS) is a chronic dermatitis predominantly found in the anogenital area. It can be found in patients of any age group, sex, or race, but is most commonly present in Caucasian peri- or postmenopausal women. Although the etiology of LS remains uncertain, an autoimmune process is believed to underlie this condition. With many cases going unreported, its incidence is still unknown. There is no cure for LS, but treatment offers control of the condition. They are three reasons for treating LS: relief of symptoms and discomfort; prevention of any or further anatomical changes; and a theoretical prevention of malignant transformation. Although many treatments have been suggested to treat LS over the years, only potent or ultra-potent corticosteroids remain as the treatment of choice. After initial therapy, some patients might only use corticosteroids as needed, while others may require a twice-weekly maintenance therapy. There is no place for surgery in uncomplicated LS. Surgery should be limited exclusively to patients with malignancy and to correct scarring secondary to the disease. Lichen sclerosus is associated with a 4-6% risk of squamous cell carcinoma, making long-term follow-up essential in these patients.

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Topical cyclosporine in the treatment of vulvar lichen sclerosus: clinical, histologic, and immunohistochemical findings

Cited by 13 publications

References 0 publications

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Evidence‐based (S3) Guideline on (anogenital) Lichen sclerosus

Lichen sclerosus: a review and practical approach

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