Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats

Alshatwi, Ali A.; Obaaid, Manal A. Al; Sedairy, Sahar A. Al; Alassaf, Abdullah; Zhang, Jun Jun; Lei, Kai Y.

doi:10.1016/j.nutres.2009.12.002

Cited by 81 publications

(60 citation statements)

References 27 publications

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“…Administration of lycopene was beneficial in efficiently restoring the SOD activity. This result corroborated with the previous studies showing increase in SOD activity on lycopene administration [56,57]. Because of high number of conjugated double bonds in lycopene, it could quench the superoxide anions and prevent oxidative stress.…”

Section: Discussionsupporting

confidence: 92%

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

2011

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Evidence from clinical and experimental studies indicate that oxidative stress is involved in pathogenesis of Parkinson's disease. The present study was designed to investigate the neuroprotective potential of lycopene on oxidative stress and neurobehavioral abnormalities in rotenone induced PD. Rats were treated with rotenone (3 mg/kg body weight, intraperitoneally) for 30 days. NADH dehydrogenase a marker of rotenone action was observed to be significantly inhibited (35%) in striatum of treated animals. However, lycopene administration (10 mg/kg, orally) to the rotenone treated animals for 30 days increased the activity by 39% when compared to rotenone treated animals. Rotenone administration increased the MDA levels (75.15%) in striatum, whereas, lycopene administration to rotenone treated animals decreased the levels by 24.33%. Along with this, significant decrease in GSH levels (42.69%) was observed in rotenone treated animals. Lycopene supplementation on the other hand, increased the levels of GSH by 75.35% when compared with rotenone treated group. The activity of SOD was inhibited by 69% in rotenone treated animals and on lycopene supplementation; the activity increased by 12% when compared to controls. This was accompanied by cognitive and motor deficits in rotenone administered animals, which were reversed on lycopene treatment. Lycopene treatment also prevented release of cytochrome c from mitochondria. Collectively, these observations suggest that lycopene supplementation along with rotenone for 30 days prevented rotenone-induced alterations in antioxidants along with the prevention of rotenone induced oxidative stress and neurobehavioral deficits. The results provide an evidence for beneficial effect of lycopene supplementation in rotenone-induced PD and suggest therapeutic potential in neurodegenerative diseases involving accentuated oxidative stress.

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Section: Discussionsupporting

confidence: 92%

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

2011

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“…Earlier studies have shown that poylphenols in tea may block the intestinal absorption of cholesterol and enhance its fecal excretion from the body [19,29]. Our previous studies have shown that the supplementation of tomato powder and lycopene to hydrogen peroxide-induced rats resulted in markedly lowered serum and liver cholesterol, TG, and serum LDL concentrations, while the serum HDL concentration was lowered [1]. The data presented herein show that BT and GT improves the serum and hepatic levels of lipid profile.…”

Section: Food Intake (%)supporting

confidence: 57%

“…However, supplementation of BT and GT caused a significant decrease in lipid peroxidation level. Earlier studies have shown that tomato powder and lycopene possess potent inhibitory effects on the intensity of LPO in serum and hepatic samples from hydrogen peroxide-induced rats [1]. In addition, Sudhahar et al [48] reported that rats fed with HCD showed a reduction in the LPO in hepatic tissue following lupeol and lupeol linoleate treatment.…”

Section: Food Intake (%)mentioning

confidence: 97%

Black and green tea improves lipid profile and lipid peroxidation parameters in Wistar rats fed a high-cholesterol diet

et al. 2010

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In the present study, the efficacy of black tea (BT) and green tea (GT) was studied in relation to serum and hepatic oxidative abnormalities in hypercholesterolemic rats. Hypercholesterolemia was induced in male Wistar rats (8 week old) by feeding them with a high-cholesterol diet (HCD) for 35 days. The experimental rats were given BT and GT as a supplement (7 g/L) via drinking water. Increased hepatic and serum lipid profile along with abnormalities in oxidative marker, with a concomitant increase in the body weight, food intake, and food efficiency, were seen in hypercholesterolemic rats. Following the supplementation of BT and GT to rats fed with HCD, significantly lower levels of serum and hepatic cholesterol, triglycerides, serum low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol levels were observed, when compared with hypercholesterolemic group. Further, significantly lower levels in the serum and hepatic lipid peroxidation, body weight gain, and food efficiency were observed in BT and GT group when compared with control and HCD fed group. However, no such significant changes were observed in the food intake upon supplementation with BT and GT. These results suggest that supplementation of BT and GT may protect against the serum and hepatic abnormalities in hypercholesterolemic rats.

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“…Serum total cholesterol level was measured using the CHODePAP method, according to the protocol of Lee (2006). The HDL level was estimated by the cholesterol precipitant method, as described by Alshatwi et al (2010), whereas LDL in serum samples was calculated from total and HDL cholesterol following the protocol of Lee (2006). Triglycerides were measured by the liquid triglycerides (GPOePAP) method, as described by Kim, Seo, Kim, and Paik (2011).…”

Section: Serum Lipid Profilementioning

confidence: 99%

Supplementation of prebiotics to a whey-based beverage reduces the risk of hypercholesterolaemia in rats

Yasmin

Butt

Baak

et al. 2015

International Dairy Journal

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Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats

Cited by 81 publications

References 27 publications

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

Black and green tea improves lipid profile and lipid peroxidation parameters in Wistar rats fed a high-cholesterol diet

Supplementation of prebiotics to a whey-based beverage reduces the risk of hypercholesterolaemia in rats

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