Black and green tea improves lipid profile and lipid peroxidation parameters in Wistar rats fed a high-cholesterol diet

Abstract

In the present study, the efficacy of black tea (BT) and green tea (GT) was studied in relation to serum and hepatic oxidative abnormalities in hypercholesterolemic rats. Hypercholesterolemia was induced in male Wistar rats (8 week old) by feeding them with a high-cholesterol diet (HCD) for 35 days. The experimental rats were given BT and GT as a supplement (7 g/L) via drinking water. Increased hepatic and serum lipid profile along with abnormalities in oxidative marker, with a concomitant increase in the body weight, food intake, and food efficiency, were seen in hypercholesterolemic rats. Following the supplementation of BT and GT to rats fed with HCD, significantly lower levels of serum and hepatic cholesterol, triglycerides, serum low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol levels were observed, when compared with hypercholesterolemic group. Further, significantly lower levels in the serum and hepatic lipid peroxidation, body weight gain, and food efficiency were observed in BT and GT group when compared with control and HCD fed group. However, no such significant changes were observed in the food intake upon supplementation with BT and GT. These results suggest that supplementation of BT and GT may protect against the serum and hepatic abnormalities in hypercholesterolemic rats.

Effect of Black Tea Intake on Blood Cholesterol Concentrations in Individuals with Mild Hypercholesterolemia: A Diet-Controlled Randomized Trial

“…9,10,17,19–21,23–27,33,36,39,60 The strong cholesterol lowering effects of black tea found in animal and cell culture studies may be due to the high doses (mg/kg) used in those studies versus most human research. Seven observational studies (six cross-sectional and one case-control) have reported that black tea consumption is correlated with lower total cholesterol in humans.…”

Nutraceuticals and dyslipidaemia: Beyond the common therapeutics

“…Many studies have evaluated the potential role of nutraceuticals in the prevention of dyslipidaemia both in animal models (Alshatwi et al, 2011;Chen et al, 2008;Dvir et al, 2009;Huang & Lin, 2012a, 2012b and in humans (Becker et al, 2009;CasasAgustench et al, 2012;Demonty et al, 2006;Dulin et al, 2006;Garaiova et al, 2013;Gonç alves et al, 2006;Guardamagna et al, 2011;Izzo et al, 2010;Maki et al, 2012;Marazzi et al, 2011;Pá rraga et al, 2011;Qin et al, 2009;Rayman et al, 2011;Sirtori et al, 2009;Tomé -Carneiro et al, 2012;Weingä rtner, Bö hm, & Laufs, 2009;Wofford et al, 2012;Wong et al, 2010;Zhao et al, 2011).…”

Effect of Black Tea Consumption on Intracellular Cytokines, Regulatory T Cells and Metabolic Biomarkers in Type 2 Diabetes Patients

“…The lipid-lowering effect of various teas, including black tea, on triglycerides, cholesterol and low-density lipoprotein, have been reported in experimental models and also in cell culture media (Alshatwi et al, 2011). Daily intake of five cups of BTE containing 7.8-mg EGCG in each cup (about 39 mg a day) caused decreases of 6.5 and 11.1% in total cholesterol and low-density lipoprotein, respectively, compared with the placebo containing caffeine, but did not affect triglyceride levels (Davies et al, 2003).…”

“…Obesity, particularly in persons with high fat diets, often is also afflicted with hyperlipidemia, which is a major risk factor for the development of cardiovascular disease and type 2 diabetes (Alshatwi et al, 2011). Approaches to reducing risk of diabetes onset and management of the disease for those afflicted include elevated tea intake, which is observed to favorably affect lipid profiles in an animal model of hypercholesterolemia (Alshatwi et al, 2011).…”

“…Obesity, particularly in persons with high fat diets, often is also afflicted with hyperlipidemia, which is a major risk factor for the development of cardiovascular disease and type 2 diabetes (Alshatwi et al, 2011). Approaches to reducing risk of diabetes onset and management of the disease for those afflicted include elevated tea intake, which is observed to favorably affect lipid profiles in an animal model of hypercholesterolemia (Alshatwi et al, 2011). Although the underlying mechanisms for the lipid-lowering effect of tea are not fully characterized, there is some evidence that tea catechinsin particular their gallate estersreduce cholesterol absorption from the intestine by lowering the solubility of cholesterol in mixed micelles (Ikeda et al, 1992).…”