Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

Kaur, Harpreet; Chauhan, Shaveta; Sandhir, Rajat

doi:10.1007/s11064-011-0469-3

Cited by 150 publications

(90 citation statements)

References 65 publications

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“…For the iron-treated group, this diet was supplemented with 1000 mg/kg diet. According to the rat's body weight, animals were intragastric administered lycopene dissolved in corn oil or 0.9% saline solution for 6 weeks (Kaur et al, 2011).…”

Section: Animals and Dietsmentioning

confidence: 99%

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

et al. 2013

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Lycopene is common in diet and known for its antioxidant activities. However, the impact of lycopene on iron metabolism is poorly investigated. In this study, we hypothesize that lycopene can prevent iron-mediated oxidative stress, proliferation and autophagy in liver and use a rat model of nutritional iron supplementation to confi rm its intervention in these defence mechanisms. We found that iron supplementation induced cell proliferation predominantly in non parenchymal cells compared with hepatocytes, but not apoptosis. In addition, iron was accumulated within the hepatic lysosomes where it triggered autophagy as evidenced by the formation of autophagic vesicles detected by LC3-B staining. Iron supplementation also induced morphologic alterations of the mitochondrial membranes probably due to increased lipid peroxidation as indicated by elevated iron and malondialdehyde concentrations in serum and tissues. Lycopene reduced iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level in the liver and colon and enhancing the total superoxide dismutase activities in serum and tissues. The result suggest that lycopene prevents iron-induced oxidative stress, proliferation and autophagy at both biochemical and histological levels due to its potent free radical scavenging and antioxidant properties.

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Section: Animals and Dietsmentioning

confidence: 99%

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

et al. 2013

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“…91 In an animal study, a beneficial effect of lycopene supplementation in rotenone-induced Parkinson's disease was demonstrated. 92 Lycopene showed protective effects against myeloid β-induced neurotoxicity in cultured rat cortical neurons 93 , 3-nitropropionic acid-induced mitochondrial oxidative stress, and dysfunctions in nervous system 94 , and trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons. 95 …”

Section: Neurodegenerative Diseasesmentioning

confidence: 97%

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

Bacanlı¹,

Başaran²,

Başaran³

2017

tjps

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It is well known that free oxygen radicals play an important role in the pathogenesis of several chronic disorders. Antioxidants are known as potential scavengers of reactive oxygen species that can protect biologic membranes against oxidative damage. Recent interest in phytochemicals has increased because of their protective effects against free oxygen radicals. Lycopene, which belongs to the carotenoid family, is the most effective singlet oxygen scavenger in vitro of all the carotenoids. Foods that contain lycopene and related supplements have been reported to prevent chronic diseases including cancer, asthma, and cardiovascular disorders. The aim of the article was to give a brief review of the antioxidant properties and beneficial health effects of lycopene.

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“…Modulation of DA, glutamate,adenosine, and other systems has been explored in various animal models of LIDs [129][130][131][132][133][134][135][136][137][138][139][140][141][142][143][144][145].…”

Section: Therapeutic Strategies For Lids In Animal Models Of Pdmentioning

confidence: 99%

Animal Models of Parkinson's Disease: A Gateway to Therapeutics?

Sayana

Jankovic

2014

Neurotherapeutics

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Parkinson's disease (PD) is a progressive, neurodegenerative disorder of unknown etiology, although a complex interaction between environmental and genetic factors has been implicated as a pathogenic mechanism of selected neuronal loss. A better understanding of the etiology, pathogenesis, and molecular mechanisms underlying the disease process may be gained from research on animal models. While cell and tissue models are helpful in unraveling involved molecular pathways, animal models are much better suited to study the pathogenesis and potential treatment strategies. The animal models most relevant to PD include those generated by neurotoxic chemicals that selectively disrupt the catecholaminergic system such as 6-hydroxydopamine; 1-methyl-1,2,3,6-tetrahydropiridine; agricultural pesticide toxins, such as rotenone and paraquat; the ubiquitin proteasome system inhibitors; inflammatory modulators; and several genetically manipulated models, such as α-synuclein, DJ-1, PINK1, Parkin, and leucine-rich repeat kinase 2 transgenic or knock-out animals. Genetic and nongenetic animal models have their own unique advantages and limitations, which must be considered when they are employed in the study of pathogenesis or treatment approaches. This review provides a summary and a critical review of our current knowledge about various in vivo models of PD used to test novel therapeutic strategies.

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Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

Cited by 150 publications

References 65 publications

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

Animal Models of Parkinson's Disease: A Gateway to Therapeutics?

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