Tolerance of combined radiochemotherapy in cervical cancer patients

Izmajłowicz, Barbara; Rusiecka, M.; Sztuder, Aleksandra; Stepień, M; Ignatowicz-Pacyna, Agnieszka; Słocka-Romaniuk, Beata; Mazur, Zbigniew; Kornafel, Jan

doi:10.17219/acem/62454

Cited by 5 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Frecuently diarrhea (56% in the INC group vs. 51.6%) was found by Izmajłowicz et al. Regarding lifestyle, risk factors such as smoking, should be addressed with re-relevance, since smoking has a RR of 2.4 (95% CI: 1.7, 3.4) and the risk remains even with smoking cessation ( RR = 1.6, 95% CI: 1.0–2.7 ) ( 60 ). The risk increases in women who smoked for a period of 16 years (OR: 3.23, 95% CI: 1.33, 7.69), and continue in recurrent smokers who consume more than 20 cigarettes a day ( OR: 2.57, 95% CI: 1.49 to 4.45 ) ( 61 ).…”

Section: Discussionmentioning

confidence: 99%

Repurposing Individualized Nutritional Intervention as a Therapeutic Component to Prevent the Adverse Effects of Radiotherapy in Patients With Cervical Cancer

Medina-Jiménez

Monroy-Torres

2020

Front. Oncol.

View full text Add to dashboard Cite

Worldwide, cervical cancer was the fourth leading cause of cancer death among women, while in Mexico was the second cause (5.28%). Cancer patients receiving chemotherapy and radiotherapy have a high risk of malnutrition secondary to the disease and treatment, affects the patient’s overall, with adverse effects on gastrointestinal symptoms. These use affects the medical therapy. The aim of the present study was to evaluate the benefits on individualized nutritional therapy on decrease weight loss and gastrointestinal adverse effects and to consider these outcomes in pharmacology research, especially in repurposing drugs. We conducted a longitudinal design with two comparation groups with medical diagnosis of cervical cancer and received radiotherapy weekly, 1) the intervention group (nutritional intervention and counseling -INC-) with 20 participants and 2) control group (retrospective cohort -CG-) with 9 participants. Weekly body composition, dietary intake, adverse effects (gastrointestinal symptoms), glucose, hemoglobin, and blood pressure were analyzed during 4 to 5 weeks. Both groups had weight loss weekly (p = 0.013 and p = 0.043 respectively) but the CG vs INC presented loss fat-free mass ≥500g in 67 and of 37% respectively. By the end of the intervention a 25% of the INC group had <10 g/dL of hemoglobin vs 60% for the CG. To compare the dietary intake of vitamins (A and folic acid), fiber (p = 0.006), iron (p = 0.03) and energy (mainly carbohydrates) (p = 0.04) were according to the recommendations in INC group (p>0.05). The number needed to treat was 4 (95% CI, 2 to 13). The nutritional intervention and counseling weekly during radiotherapy in cervical cancer to maintain/improve muscle mass, hemoglobin, and dietary intake above 70% of the recommendations for INC group compared to the evidence. Adequate nutritional status was maintained and decrease the rate of complications, mainly gastrointestinal symptoms, in INC group. The efficacy of drug repurposing can improve through individualized nutritional therapy for preventing adverse effects of radiotherapy in patients with cervical cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Repurposing Individualized Nutritional Intervention as a Therapeutic Component to Prevent the Adverse Effects of Radiotherapy in Patients With Cervical Cancer

Medina-Jiménez

Monroy-Torres

2020

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…A very important aspect of each specific oncological therapy is the implementation of the total planned course of treatment. The literature suggests that only 65-92% of patients receive the planned number of chemotherapy cycles [31]. This is often caused by the appearance of serious manifestations of ART [31].…”

Section: Discussionmentioning

confidence: 99%

“…The literature suggests that only 65-92% of patients receive the planned number of chemotherapy cycles [31]. This is often caused by the appearance of serious manifestations of ART [31]. It has been shown that patients from the control group received more than four cycles of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Acute chemoradiotherapy toxicity in cervical cancer patients

et al. 2020

View full text Add to dashboard Cite

During radiotherapy treatment for cervical cancer, up to 84% of patients exhibit some form of acute radiation toxicity (ART). The primary aim of this clinical study is to determine the impact of angiotensin-converting enzyme (ACE) inhibitors, β-blockers and other risk factors such as the patient’s anatomical characteristics on ART emergence in patients with locally advanced cervical cancer treated by chemoradiotherapy. This is a combination of two nested case–control studies within the cohort of patients with locally advanced cervical cancer based on the analysis of potential risk factors for the onset of ART in patients treated with 3D conformal radiotherapy (3D-CRT) and 2D conventional radiotherapy (2D-RT), prospectively followed up from January 2017 to September 2018 in a tertiary care hospital. The ACE inhibitors and bladder volume were identified as factors that significantly affect the occurrence of ART in patients treated with 3D-CRT. In patients treated with 2D-RT, the factors that significantly affect the occurrence of ART were ACE inhibitors, body mass index (BMI), brachytherapy rectal and bladder dose. This study has shown that BMI, radiation dose received by the bladder and rectum are of exceptional importance for the occurrence of the ART and also that therapy with ACE inhibitors was associated with the decreased chances of the ART.

show abstract

“…O entendimento da QVRS por parte do paciente e profissionais é fundamental para uma escolha conjunta das medidas terapêuticas que serão utilizadas, observando caso a caso e visando minimizar os efeitos do câncer e do tratamento. Pacientes que se submetem ao tratamento combinado de quimioterapia e radioterapia (CCRT) podem apresentar reações como: alterações hematológicas, náuseas, vômitos, diarreia, problemas pós-radiação precoce em trato gastrointestinal e bexiga 8 . Assim como estresse significativo, angústia existencial, depressão, ansiedade, insônia, tanto durante o tratamento, quanto na sobrevivência 9 .…”

Section: Introductionunclassified

Imagem guiada para qualidade de vida de mulheres com câncer cervical: estudo quase experimental

Santana

Marcondes²,

Silva³

et al. 2023

Rev Cuid

View full text Add to dashboard Cite

Introducción: Las terapias de mente y cuerpo, como la relajación de imágenes guiadas, que se encuentran entre las principales prácticas integradoras utilizadas por los pacientes con cáncer, son esenciales para mantener un equilibrio saludable entre la activación simpática y parasimpática en el cerebro. Objetivo: Evaluar el efecto de la relajación de imagen guiada, con el uso de realidad virtual, sobre la calidad de vida relacionada con la salud de mujeres con cáncer de cuello uterino en tratamiento concomitante con quimiorradioterapia. Materiales y Método: Estudio cuasi-experimental, realizado en un hospital de referencia de oncología en el sur de Brasil, de octubre de 2019 a enero de 2021. Participaron 52 mujeres, divididas en dos grupos, experimental (intervención de relajación guiada por imaginería con realidad virtual), y control (rutina por defecto). El instrumento funcional se utilizó para evaluar las puntuaciones de calidad de vida relacionada con la salud. Evaluación de Cáncer terapia cuello uterino cáncer, aplicado antes, 14 días después y al final del tratamiento, en aproximadamente 35 días. Los análisis se realizaron utilizando el modelo lineal generalizado mixto, con una matriz de covarianza autorregresiva de orden 1, y la significación fue confirmada por la prueba de Sidak. Resultados: hubo una diferencia estadísticamente significativa para el grupo experimental en la calidad de vida física (p = 0,02), funcional (p = 0,00), síntomas específicos del cáncer de cuello uterino y efectos del tratamiento (p = 0,03) y en general (p = 0,02).). Conclusión: La Relajación por Imagen Guiada contribuyó a mejorar la Calidad de Vida Relacionada con la Salud de las pacientes con cáncer de cuello uterino durante el tratamiento con quimiorradioterapia. Como citar este artículo: Santana, Edenice de Oliveira; Marcondes, Larissa; Silva, Luana Aparecida Alves da; Sawada, Namie Okino; Rosa, Luciana Martins da; Kalinke, Luciana Puchalski. Imagem guiada para qualidade de vida de mulheres com câncer cervical: estudo quase experimental. Revista Cuidarte. 2023;14(1):e2358. http://dx.doi.org/10.15649/cuidarte.2358

show abstract

Tolerance of combined radiochemotherapy in cervical cancer patients

Cited by 5 publications

References 32 publications

Repurposing Individualized Nutritional Intervention as a Therapeutic Component to Prevent the Adverse Effects of Radiotherapy in Patients With Cervical Cancer

Repurposing Individualized Nutritional Intervention as a Therapeutic Component to Prevent the Adverse Effects of Radiotherapy in Patients With Cervical Cancer

Acute chemoradiotherapy toxicity in cervical cancer patients

Imagem guiada para qualidade de vida de mulheres com câncer cervical: estudo quase experimental

Contact Info

Product

Resources

About