Tolerance in vivo and in vitro

Tomonari, Kuyhei

doi:10.1111/j.1600-065x.1990.tb00808.x

Cited by 27 publications

(9 citation statements)

References 49 publications

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“…In the case of sMLR culture, the T cells proliferate in response to self non-T cells and differentiate to cytotoxic T cells, with characteristics similar to NK cells [38]. Our results also revealed an increase in the activity of NK and LAK in the spleen cells and lymph node cells of aged mice with a high activity of sMLR response and an increased level of y gene transcripts.…”

Section: Discussionsupporting

confidence: 57%

Age‐associated increase in the expression of T cell antigen receptor γ chain genes in mice

et al. 1988

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T cell function generally declines with age. To determine the underlying cause of the age-related decline, we compared the expression levels of T cell antigen receptor genes encoding gamma, beta and alpha chains in the lymphoid tissues of young (8 wk old) vs. aged (40 wk old) mice. An age-associated increase in gamma chain gene transcripts was evident in the thymocytes, spleen cells and mesenteric lymph node cells. Aged mice had a relatively high proportion of CD3+CD4-CD8- cells but a reduced level of CD3+CD4-CD8+ cells in the lymphoid tissues, as compared with young counterparts. The allo-reactivity in the lymphoid cells, as assessed by mixed lymphocyte reaction (MLR) responses, decreased with advancing age. On the contrary, increased levels of syngeneic MLR and spontaneous cytolytic activity were noted in the lymphoid cells of aged mice, as compared with findings in their young counterparts. A remarkable increase in the number of CD3+CD4-CD8- cells and level of the gamma chain gene messages was also detected in the responder cells of day 4 syngeneic MLR culture from aged mice. An increase in the number of T cells bearing gamma chain may be related to the alterations in immunological functions in aged mice.

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Section: Discussionsupporting

confidence: 57%

Age‐associated increase in the expression of T cell antigen receptor γ chain genes in mice

et al. 1988

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“…(NOD × NIH)F 1 × NIH backcross mice were bred and H-2 haplotypes established; all of the offspring will express vSAG-7 and vSAG-8 encoded by the NIH genome. Mtv-8 encodes a weak superantigen which, when presented by H-2E, mediates a partial deletion of V g 11 + T cells and lacks the ability to stimulate the activation of perpheral V g 11 + T cells [16,17]; conversely, vSAG-7 is a potent superantigen mediating, in the presence of H-2E, a near total elimination of V g 6 + T cells and delivers a strong proliferative signal to peripheral T cells. Because T cell depletion mediated by endogenous superantigens is generally more complete in the CD4 + compartment in comparison to the CD8 + compartment, V g staining was assessed within both LN T cell populations.…”

Section: Vsag-7 and Vsag-8 Presentation By A G7mentioning

confidence: 97%

Efficient presentation of endogenous superantigen by H-2Aq

et al. 1998

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Endogenous superantigens encoded by mouse mammary tumor viruses associate with MHC class II and interact with T cells bearing particular V beta gene segments. H-2E is more efficient at presentation than H-2A, indeed Aq has not been shown to be capable of presenting endogenous superantigens. Atypically, the superantigen vSAG-3 encoded by Mtv-3 is presented efficiently in non-obese diabetic (H-2g7) mice by H-2A; we have examined the independent contributions of vSAG-3 and Ag7 to this process. Ag7 was not found to have a more general ability to efficiently present endogenous superantigens other than Mtv-3. Examination of Mtv-3-mediated thymic deletion of V beta 3+ thymocytes in the presence of H-2q additionally demonstrated the efficient presentation of vSAG-3 by Aq. Interaction of vSAG-3 with Aq and Ag7 is likely to reflect the unique sequence of Mtv-3 within the second polymorphic region previously implicated in MHC class II binding. The demonstration that mouse endogenous superantigens can be presented by a wider range of MHC haplotypes than previously thought is further evidence for their immunological impact on the mouse population.

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“…The chromosomal mapping of Mlsc proved complex and from backcross studies it became clear that a number of independently segregating genes could give rise to this phenotype [lo]. A similar story of several genes giving rise to a similar phenotype-VP specific deletion but not accompanied by Mls activity in MLC-started to emerge for deletion of Vp5+ T cells [ll] and Vp11+ T cells [12]. In both cases, the chromosome mapping hinged on deletion needing H-2E molecules plus a ligand encoded by an independently segregating gene(s), present in some but not all mouse strains.…”

Section: Negative Selectionmentioning

confidence: 99%

Positive and Negative Selection of the T Cell Repertoire: Role of MHC and Other Ligands

Simpson

1992

International Reviews of Immunology

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Tolerance in vivo and in vitro

Cited by 27 publications

References 49 publications

Age‐associated increase in the expression of T cell antigen receptor γ chain genes in mice

Age‐associated increase in the expression of T cell antigen receptor γ chain genes in mice

Efficient presentation of endogenous superantigen by H-2Aq

Positive and Negative Selection of the T Cell Repertoire: Role of MHC and Other Ligands

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