Efficient presentation of endogenous superantigen by H-2Aq

Dyson, Pamela; Elliott, James I.; Antoniou, Antony N.; Corley, Kevin T.T.

doi:10.1002/(sici)1521-4141(199803)28:03<1034::aid-immu1034>3.0.co;2-o

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…To address this question either MMTV transgenic mice or congenic mice harboring a natural endogenous copy of an infectious virus were used which clonally delete the superantigen-reactive T cells in the thymus and hence are not able to mount a superantigen response (99,100). Alternatively, mice expressing an MHC haplotype not able to present MMTV superantigens were infected (I-E-dependent superantigen in I-E-non-expressing mice) or virus transmission was studied in B, CD4 or T cell-deficient mice (6,58,75,101,102). In all these models the superantigen was, as expected, absent and the amplification of infected B cells did not take place.…”

Section: Role Of the Superantigen Response For Infectionmentioning

confidence: 99%

Immune response to MMTV infection

Acha‐Orbea

Shakhov²,

Finke³

2007

Front Biosci

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Introduction 3. Structure, expression and transmission of the virus 4. Superantigens 5. The structure of the superantigen orf 6. Normal T-dependent immune responses 7. Live cycle of MMTV, exploiting the T cell-dependent B cell immune response 7.1. Entry of infectious MMTV in Peyer's patches 7.2. Infection of dendritic cells and B cells 7.3. Superantigen-mediated induction of helper T cells 7.4. Formation of germinal centers and long-lived memory cells 7.5. Fate of superantigen-reactive T cells 7.6. Transmission to the mammary gland 7.7. Mammary tumors 7.8. Role of the superantigen response for infection 7.9. Role of virus neutralization 8. Perspectives and conclusions 9. Acknowledgments 10. References

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Section: Role Of the Superantigen Response For Infectionmentioning

confidence: 99%

Immune response to MMTV infection

Acha‐Orbea

Shakhov²,

Finke³

2007

Front Biosci

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“…Stimulation of V␤6 ϩ T cells by vSAg7 is known to be strongly dependent on the expression of I-E in the presenting cells (23). Thus, in view of the fact that SW ϫ J-1 is H2 s , it seemed likely that vSAg7 could not properly be presented by the lymphoma cells (24). Indeed, when the abilities of LPS-stimulated B cells from SWR (H2 q , Mtv7 ϩ ) and BALB.D2 (H2 d , Mtv7 ϩ ) to stimulate these V␤6 ϩ T hybridoma cells were compared, the SWR cells failed to stimulate (Ͻ 0.15 pg IL-2/ml), whereas the BALB.D2 cells did (1.55 pg IL-2/ml).…”

Section: Stimulation Of Syngeneic T Cells and Of T Hybridoma Cells Bymentioning

confidence: 99%

META-Controlled env-Initiated Transcripts Encoding Superantigens of Murine Mtv29 and Mtv7 and Their Possible Role in B Cell Lymphomagenesis

Sen

Simmons²,

Thomas

et al. 2001

The Journal of Immunology

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Spontaneous germinal center (GC)-derived B cell lymphomas of SJL mice (RCS) transcribe a 1.8-kb Mtv-29 mRNA under control of the META-env promoter. The encoded vSAg29 stimulates syngeneic Vβ16+ CD4+ T cells, thereby acquiring T cell help necessary for RCS growth. Other strains of B cell lymphoma-prone mice include Mtv29+ C57L and MA/MyJ, and the Mtv29− Mtv7+-recombinant inbred strain, SW × J-1. The lymphomas of these mice produce similar mouse mtv-vSAg-encoding mRNA, as characterized by Northern blotting, PCR, and RNase protection. A 1.8-kb mRNA in C57L/J and MA/MyJ lymphomas hybridized with an Mtv29-specific oligonucleotide, whereas SW × J-1 lymphomas produced 1.8-kb transcripts hybridizing with an Mtv7-specific oligonucleotide. Similar META-env-initiated transcripts were absent from LPS-activated B cells from any strain examined but were detected in Peyer’s patch RNA from SJL mice. Like typical SJL-derived RCS, all these lymphomas stimulated syngeneic CD4+ T cells and Vβ16+ T hybridoma cells. Immunohistochemical staining of primary tumors showed the presence of peanut agglutinin binding (PNA+) highly mitotic lymphoblasts, suggesting their GC derivation. The findings indicate that this novel mRNA for Mtv29 is present in B cell lymphomas from several Mtv29+ mouse strains. Additionally, this is the first description of the ability of Mtv7 to produce transcripts that are controlled and spliced identically to those of Mtv29 and that are expressed in SW × J-1, I-As+, lymphomas that also stimulate Vβ16+ T cells. Our results suggest an important role for mouse mtv-vSAgs and Vβ16 T cell stimulation in the development of GC-derived murine B cell lymphomas.

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Chronic deletion, escape from deletion and activation of mouse mammary tumor virus superantigen-reactive T cells in C57BL/10 mice

Dyson

Elliott

1999

Eur. J. Immunol.

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Though C57BL/10 mice express the mouse mammary tumor virus superantigens (sag) encoded by Mtv-8 and Mtv-9, it has been thought that these sag do not bind to the MHC class II molecule H2-Ab and consequently do not affect the T cell repertoire. However, we show that cells bearing TCR Vbeta chains specific for Mtv-8 and -9 sag are chronically deleted in C57BL/10 mice. Thymocytes and peripheral T cells escaping deletion by Mtv sag display a small reduction in the level of cell surface CD4. T cells escaping thymic deletion respond variably to endogenous Mtv sag with some, but not all, reactive populations appearing overrepresented in the activated/memory subset. The data suggest that in normal mice fine modulation of coreceptor expression levels may be a common way by which thymocytes escape elimination, that systems utilizing potentially Mtv sag-reactive TCR on a C57BL background may be inappropriate for the measurement of the affinity of TCR/MHC/peptide interactions required in thymic selection, and that detection of the activity of human sag may be aided by analysis of CD4 levels and activation markers on T cells in conjunction with studies of the frequency of cells bearing specific TCRVbeta chains.

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Efficient presentation of endogenous superantigen by H-2Aq

Cited by 4 publications

References 25 publications

Immune response to MMTV infection

Immune response to MMTV infection

META-Controlled env-Initiated Transcripts Encoding Superantigens of Murine Mtv29 and Mtv7 and Their Possible Role in B Cell Lymphomagenesis

Chronic deletion, escape from deletion and activation of mouse mammary tumor virus superantigen-reactive T cells in C57BL/10 mice

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