Tocotrienol-Rich Fraction Modulates Cardiac Metabolic Profile Changes in Isoprenaline-Induced Myocardial Infarction Rats

Zarkasi, Khairul Anwar; Zainalabidin, Satirah; Tan, Jun; Hakimi, Nur Haleeda; Ramli, Nur Zuliani; Jubri, Zakiah

doi:10.17576/jsm-2020-4902-14

Cited by 4 publications

(4 citation statements)

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“…The changes in the redox balance during the ISO in the myocardial tissue are well documented. 41 , 43 In the current study, the reduction of GSH, SOD, GPx and SOD were observed in the heart tissue. This reduction occurred due to the utilization of more cellular enzymatic and non-enzymatic antioxidants to scavenge the free radicals generated during ISO treatment.…”

Section: Discussionsupporting

confidence: 51%

Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

Cheng¹,

Zhang²,

Jia³

et al. 2022

JIR

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Background Myocardial ischemic/reperfusion (I/R) injury is a key prognostic factor after the myocardial infarction. However, at the time of reperfusion, the myocardial tissue has undergone for the necrosis and initiated the induction of oxidative stress and inflammation. The current study was to scrutinize the cardioprotective effect of gossypin against ISO-induced I/R injury in myocardial tissue and explore the possible underlying mechanism. Methods Sprague Dawley (SD) was used in the current protocol and ISO was used for induction the I/R in rat. The rats were divided into different groups and received the oral administration of gossypin treatment before the reperfusion. The body weight, heart weight and heart body weight ratio were estimated. The antioxidant, cardiac injury parameters, inflammatory cytokines, inflammatory mediators, gut microbiota and lipid parameters were estimated. At the end, heart tissue histopathological study was carried out. Results ISO-induced I/R rats received the gossypin treatment significantly (P < 0.001) enhanced the body weight and decreased the heart weight, along with suppressed the infarct size. Gossypin treatment significantly (P < 0.001) reduced the level of heart parameters, such as creatinine kinase-MB (CK-MB), lactate dehydrogenase (LDH), creatine kinase (CK), cardiac troponin I (CTn-I) and cardiac troponin T (CTn-T) in the serum. Gossypin treatment significantly (P < 0.001) altered the cardiac function, hepatic, antioxidant, inflammatory cytokines and inflammatory mediators. Gossypin significantly (P < 0.001) suppressed the MMP-2 and MMP-9 in ISO-induced I/R rats. Gossypin treatment considerably alleviated the gut dysbiosis through altered Firmicutes to Bacteroidetes (F/B) ratio and also maintained the relative abundance of Butyricicoccus, Clostridium IV, Akkermansia, Roseburia and Clostridium XIVs. Conclusion Based on result, we can conclude that gossypin is an alternative drug for the treatment of ISO-induced I/R in rats via alteration of oxidative stress, inflammatory reaction and gut microbiota.

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Section: Discussionsupporting

confidence: 51%

Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

Cheng¹,

Zhang²,

Jia³

et al. 2022

JIR

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“…It could enhance the GSH pool via several mechanisms. Firstly, vitamin E promotes GSH synthesis by increasing the bioavailability of the GSH precursor, γ-glutamylcysteine [ 189 ]. Additionally, vitamin E could stimulate GR enzyme activity in the brain resulting in a more efficient conversion of GSSG back to GSH [ 190 ].…”

Section: Dysregulation Of Antioxidant and Pro-oxidant Enzymesmentioning

confidence: 99%

A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

et al. 2020

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Nutraceuticals have been extensively studied worldwide due to its neuroprotective effects in in vivo and in vitro studies, attributed by the antioxidative properties. Alzheimer (AD) and Parkinson disease (PD) are the two main neurodegenerative disorders that are discussed in this review. Both AD and PD share the similar involvement of oxidative stress in their pathophysiology. Nutraceuticals exert their antioxidative effects via direct scavenging of free radicals, prevent damage to biomolecules, indirectly stimulate the endogenous antioxidative enzymes and gene expressions, inhibit activation of pro-oxidant enzymes, and chelate metals. In addition, nutraceuticals can act as modulators of pro-survival, pro-apoptotic, and inflammatory signaling pathways. They have been shown to be effective particularly in preclinical stages, due to their multiple mechanisms of action in attenuating oxidative stress underlying AD and PD. Natural antioxidants from food sources and natural products such as resveratrol, curcumin, green tea polyphenols, and vitamin E are promising therapeutic agents in oxidative stress-mediated neurodegenerative disease as they have fewer adverse effects, more tolerable, cheaper, and sustainable for long term consumption.

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“…e administration of tocotrienol-rich fraction (200 mg/kg) for about three months showed a positive impact on the myocardial antioxidative system in rats via new GSH synthesis [11].…”

Section: Introductionmentioning

confidence: 96%

Occurrence of Tocols in Foods: An Updated Shot of Current Databases

Durazzo¹,

Nazhand

Lucarini³

et al. 2021

Journal of Food Quality

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Tocols are present in various foods, mostly in fruits and in plant seeds. Edible oils are the most important natural dietary sources of tocopherols and tocotrienols, collectively known as tocols. Tocopherols and tocotrienols are considered beneficial for their antioxidant effect which impacts on prevention of different health conditions. This perspective is addressed to give an updated picture of the tocol occurrence in foods. Moreover, the current state of the art of tocols in updated databases is explored and commented outlining their importance and future trends.

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Tocotrienol-Rich Fraction Modulates Cardiac Metabolic Profile Changes in Isoprenaline-Induced Myocardial Infarction Rats

Cited by 4 publications

References 0 publications

Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

Cardioprotective Effect of Gossypin Against Myocardial Ischemic/Reperfusion in Rats via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

Occurrence of Tocols in Foods: An Updated Shot of Current Databases

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