Tocopherols in cancer: An update

Gupta, Saurabh; Suh, Nanjoo

doi:10.1002/mnfr.201500847

Cited by 95 publications

(47 citation statements)

References 81 publications

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“…Apigenin has been suggested as a potent antitumor agent for cervical cancer . Tocols and carotenoids are micronutrients in wheat, and their anticancer activities have been demonstrated in vitro and in vivo studies .…”

Section: Health‐promoting Effects Of Wheat Phytochemicalsmentioning

confidence: 99%

Phytochemicals in whole grain wheat and their health‐promoting effects

Zhu

Sang

2017

Molecular Nutrition Food Res

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Accumulated evidence in epidemiological studies has consistently shown that consumption of whole grains (WGs) is inversely associated with risk of major chronic diseases such as certain types of cancer, type 2 diabetes, and cardiovascular diseases. Dietary fiber (DF) has been reported to be responsible for the health effects of WG consumption. Evidence from in vitro and in vivo studies is emerging that, in addition to DF and minerals, the unique phytochemicals in WGs may in part contribute to these health-promoting effects. WGs are rich sources of various phytochemicals. However, phytochemical contents and profiles in WG wheat are not systematically summarized yet, and the rapid rate of discovery of wheat phytochemicals necessitates an update on the current state of this field. Furthermore, the biological roles of phytochemicals in protective effects of WGs are also relatively underestimated compared to DFs. This manuscript summarized current research literature regarding phytochemicals that have been identified and characterized from wheat grains and wheat bran, and their corresponding contributions to the major health benefits of WG wheat consumption.

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Section: Health‐promoting Effects Of Wheat Phytochemicalsmentioning

confidence: 99%

Phytochemicals in whole grain wheat and their health‐promoting effects

Zhu

Sang

2017

Molecular Nutrition Food Res

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“…The clinical trials were carried out with α-tocopherol"classical vitamin E” and the most abundant form in human tissues and plasma, but results have been disappointing. Recent epidemiological and preclinical studies have indicated that γ- and δ-tocopherols may be more effective because they are more efficient traps for reactive oxygen and nitrogen species (13, 19, 37). To better understand the biological activities of the different forms of tocopherols as potential inhibitors of estrogen-mediated breast cancer, we examined the effects of α-, γ-, δ-tocopherols and γ-TmT on MCF-7 cells in vitro and in vivo in xenograft tumors.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of γ- and δ-Tocopherols on Estrogen-Stimulated Breast Cancer In Vitro and In Vivo

Bak

Gupta

Wahler

et al. 2017

Cancer Prevention Research

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Estrogens have been implicated as complete carcinogens for breast and other tissues through mechanisms involving increased cell proliferation, oxidative stress and DNA damage. Because of their potent antioxidant activity and other effects, tocopherols have been shown to exert anti-tumor activities in various cancers. However, limited information is available on the effect of different forms of tocopherols in estrogen-mediated breast cancer. To address this, we examined the effects of α-, γ- and δ-tocopherols as well as a natural γ-tocopherol rich mixture of tocopherols, γ-TmT, on estrogen-stimulated MCF-7 cells in vitro and in vivo. For the in vivo studies, MCF-7 cells were injected into the mammary fat pad of immunodeficient mice previously implanted with estrogen pellets. Mice were then administered diets containing 0.2% α-, γ-, δ-tocopherol or γ-TmT for 5 weeks. Treatment with α-, γ-, δ-tocopherols and γ-TmT reduced tumor volumes by 29% (p<0.05), 45% (p<0.05), 41% (p<0.05) and 58% (p<0.01), as well as tumor weights by 20%, 37% (p<0.05), 39% (p<0.05) and 52% (p<0.05), respectively. γ- and δ-Tocopherols and γ-TmT inhibited the expression of cell proliferation-related genes such as cyclin D1 and c-Myc, and estrogen-related genes such as TFF/pS2, cathepsin D and progesterone receptor in estrogen-stimulated MCF-7 cells in vitro. Further, γ- and δ-tocopherols decreased the levels of estrogen-induced oxidative stress and nitrosative stress markers, 8-hydroxy-2’-deoxyguanosine and nitrotyrosine, as well as the DNA damage marker, γ-H2AX. Our results suggest that γ- and δ-tocopherols and the γ-tocopherol rich mixture are effective natural agents for the prevention and treatment of estrogen-mediated breast cancer.

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“…Qader et al [38] demonstrated that the PM extract exhibited the highest phenolic content (55.5 mg/g) compared to five Malaysia herbs using ethanol aqueous as solvent extraction. On the other hand, Tp is one of polyphenol compound that naturally obtained from oils, vegetables and nuts possess the strong antioxidant capacity and pharmacological benefits towards human health [39]. Many studies on pharmacology showed potent compound of vitamin E used as anticancer, antitumor and antioxidant agent [15][16]39].…”

Section: Total Phenolic Content (Tpc) and Antioxidant Activity Of Pm mentioning

confidence: 99%

Semirefined Carrageenan (SRC) Film Incorporated with α-Tocopherol and <i>Persicaria minor</i> for Meat Patties Application

et al. 2019

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Semirefined carrageenan (SRC) plasticized with glycerol (G) and incorporated with antioxidants of 0.4% (v/v) of α-tocopherol and Persicaria minor (PM) extract was successfully developed. The objective of this study is to analyze the antioxidant effect of active packaging films from semirefined carrageenan incorporated with α-tocopherol and Persicaria minor on meat patties. Total phenolic content and antioxidant activity of α-tocopherol and PM extract were measured. The effects of α-tocopherol and PM extract incorporated with SRC-based films on meat patties were evaluated using thiobarbituric acid reactive substance (TBARS) assay, metmyoglobin assay, and pH value for 14 days of storage. The films with 0.4% (v/v) of α-tocopherol and PM extract exhibited a lower lipid oxidation in meat patties compared with that of control (SRC film only, p < 0.05). Also, a brown color development of the meat patties of less than 50% was observed at the end of the 14-day storage. Meanwhile, the pH values for all samples decreased throughout the storage period with the SRC+G+α-tocopherol film showed the highest pH value. Hence, the formulation of SRC film with α-tocopherol or PM extract could be used as an alternative packaging for extending the shelf life of food product with high fat content.

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Tocopherols in cancer: An update

Cited by 95 publications

References 81 publications

Phytochemicals in whole grain wheat and their health‐promoting effects

Phytochemicals in whole grain wheat and their health‐promoting effects

Inhibitory Effects of γ- and δ-Tocopherols on Estrogen-Stimulated Breast Cancer In Vitro and In Vivo

Semirefined Carrageenan (SRC) Film Incorporated with α-Tocopherol and <i>Persicaria minor</i> for Meat Patties Application

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