Tobacco and alcohol use during pregnancy and risk of oral clefts. Occupational Exposure and Congenital Malformation Working Group

Lorente, Caridad de la Paz; Cordier, Sylvaine; Goujard, J; Aymé, Ségolène; Bianchi, Fabrizio; Calzolari, Elisa; Walle, Hermien E. K. de; Knill‐Jones, R. P.

doi:10.2105/ajph.90.3.415

Cited by 107 publications

(7 citation statements)

References 26 publications

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“…Many of those papers reported an association of smoking with combined oral clefts (Ericson et al, 1979; Van den Eeden et al, 1990; Chung et al, 2000; Wyszynski et al, 2002; Van Rooij et al, 2002; Shi etal., 2007; Shaw et al, 2009 , Hackshaw et al, 2011), or found statistically significant associations for both CL±P and CP (Khoury et al, 1987; Khoury et al, 1989; Shaw et al, 1996; Kallen, 1997; Wyszynski et al, 1997; Little et al, 2004a, 2004b; Meyer et al, 2004; Zeiger et al, 2005). The current study found statistically significant associations only with CL±P, which is consistent with several studies that examined both phenotypes (Lorente et al, 2000; Honein et al, 2007; Lie et al, 2008; Liete and Koifman, 2009), though one study found effects only with CP (Romitti et al, 1999). Some studies reported no association of smoking with combined clefts or with CL±P or CP (Hemminki et al, 1983; Werler et al, 1990; Christensen et al, 1999; Van Rooij et al, 2001; Grewal et al, 2008).…”

Section: Discussionsupporting

confidence: 92%

Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Risk of Oral Cleft-Affected Pregnancies

Langlois

Hoyt

Lupo

et al. 2013

The Cleft Palate-Craniofacial Journal

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Objective Evaluate whether there is an association between maternal occupational exposure to polycyclic aromatic hydrocarbons (PAHs) and oral cleftsin offspring. This is the first human study of PAHs and clefts of which the authors are aware. Design Case-control study. Setting, Participants Data for 1997–2002 from the National Birth Defects Prevention Study, a large population-based case-control study in the US, were analyzed. Maternal telephone interviews yielded information on jobs held in the month before through three months after conception. Two industrial hygienists independently assessed occupational exposure to PAHs ; all jobs rated as exposed or with rating difficulty were reviewed with a third industrial hygienist to reach consensus on all exposure parameters. Logistic regression estimated crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for cleft lip with or without cleft palate (CL±P) and cleft palate alone (CP). Results There were 2989 controls( 3.5% exposed), 805 cases of CL±P (5.8% exposed) and 439 cases of CP (4.6% exposed). The odds of maternal occupational exposure to PAH (any vs none) during pregnancy was increased for CL±P cases as compared with controls (OR 1.69, 95% CI 1.18–2.40); the OR was 1.47 (95% CI 1.02–2.12) adjusted for maternal education. There was a statistically significant adjusted exposure-response relationship for CL±P (ptrend = 0.02). ORs for CP were not statistically significant. Conclusions Maternal occupational exposure to PAHs was associated with increased risk of cleft lip with or without cleft palate in offspring.

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Section: Discussionsupporting

confidence: 92%

Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Risk of Oral Cleft-Affected Pregnancies

Langlois

Hoyt

Lupo

et al. 2013

The Cleft Palate-Craniofacial Journal

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“…Besides data confirming the role of genetics in the aetiology of OFCs, scientific studies and epidemiological data show that environmental risk factors (e.g., smoking, alcohol and malnutrition in pregnancy, viral infections, teratogenic pharmacological agents, folate deficiency, weight) intervene significantly in the complex embryological development determining malformation [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Inchingolo

Fatone²,

Malcangi

et al. 2022

Children

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OFCs (orofacial clefts) are among the most frequent congenital defects, but their etiology has yet to be clarified. OFCs affect different structures and functions with social, psychological and economic implications in children and their families. Identifying modifiable risk factors is mandatory to prevent the occurrence of non-syndromic OFCs (NSOFCs). PubMed, Cochrane Library, Scopus and Web of Science were searched from 1 January 2012 to 25 May 2022 and a total of 7668 publications were identified. Studies focusing on the risk factors of NSOFCs were selected, leading to 62 case-control and randomized clinical trials. Risk factors were categorized into non-modifiable and modifiable. The first group includes genetic polymorphisms, gender of the newborn, ethnicity, and familiarity. Within the second group, risk factors that can only be modified before conception (consanguinity, parental age at conception, socio-economical and educational level, area of residency and climate), and risk factors modifiable before and after conception (weight, nutritional state, acute and chronic diseases, psychophysical stress, licit and illicit drugs, alcohol, smoke, pollutants and contaminants) have been distinguished. This study provides a wide overview of the risk factors of NSOFCs, focusing on modifiable ones, to suggest new perspectives in education, prevention, medical interventions and clinical research.

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“…The women were part of a multicenter European case-referent study conducted using 6 congenital malformation registers between 1989 and 1992. Analysis suggests that occupational exposures such as aliphatic aldehydes, glycol ethers, lead compounds, biocides, antineoplastic drugs, trichloroethylene, and aliphatic acids are associated with orofacial clefts [96]. …”

Section: Occupational Factorsmentioning

confidence: 99%

Risk factors involved in orofacial cleft predisposition – review

Kawalec

Nelke²,

Pawlas

et al. 2015

Open Medicine

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Clefts that occur in children are a special topic. Avoiding risk factors, and also an early diagnosis of cleft possibility can result in minimizing or avoiding them. If on the other hand when clefts occur they require a long-term, multistage specialized treatment. Etiology of clefts seems to be related to many factors. Factors such as genetic, environmental, geographic and even race factors are important. Identification of risk factors can lead to prevention and prophylactic behaviors in order to minimize its occurrence. Exposure to environmental factors at home and work that lead to cleft predisposition should not be disregarded. It seems that before planning a family it would be wise to consult with doctors of different specializations, especially in high-risk families with cleft history in order to analyze previous lifestyle. Clefts are very common in hereditary facial malformations and are causing a lot of other irregularities in the head and neck region. In this paper after a brief papers review authors present socio-geographic, environmental and also work place related factors that are influencing pregnant women condition and should be taken under serious consideration.

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Tobacco and alcohol use during pregnancy and risk of oral clefts. Occupational Exposure and Congenital Malformation Working Group

Cited by 107 publications

References 26 publications

Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Risk of Oral Cleft-Affected Pregnancies

Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Risk of Oral Cleft-Affected Pregnancies

Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review

Risk factors involved in orofacial cleft predisposition – review

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