TNF-α -308G/A polymorphism and susceptibility to tuberculosis in Azeri population of Iran

Ghorghanlu, Sajjad; Asgharzadeh, Mohammad; Kafil, Hossein Samadi; Khaki‐Khatibi, Fatemeh; Rashedi, Jalil; Mahdavi, Poor; Moaddab, Seyyed Reza; Pourostadi, Mahya

doi:10.2298/gensr1603819g

Cited by 3 publications

(2 citation statements)

References 21 publications

(31 reference statements)

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“…Ethnic-specific genetic variation can influence the immune responses to microbial pathogens. Linkage disequilibrium in specific ethnic population can also affect the association studies [21]. Lifestyle factors such as smoking and alcohol consumption habits and food or diet type also influence the susceptibility to TB.…”

Section: Discussionmentioning

confidence: 99%

“…The interaction between host gene-gene, host agent, and the effect of lifestyle on our association results is also unknown. [18] No association with TB 93 PTB patients 103 NC Iranian Anoosheh et al [19] No association with PTB 151 PTB patients 83 NC Iranian Ghamari et al [20] No association with PTB 124 TB patients 200 NC Azeri Iranian Ghorghanlu et al [21] No association with TB 128 TB patients 80 NC Turkish Ates et al [22] No association with PTB 149 TB patients 147 NC Thai Vejbaesya et al [23] No association with TB 185 TB patients 155 NC North Indian Sharma et al [24] No association with TB 190 PTB, 183 STB 362 NC South Chinese Zhou et al [25] No association with PTB and STB TB: Tuberculosis; PTB: Pulmonary tuberculosis; NC: Normal control; STB: Spinal tuberculosis. https://www.id-press.eu/mjms/index…”

Section: Discussionmentioning

confidence: 99%

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Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

Sinaga

Amir

2021

Open Access Maced J Med Sci

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BACKGROUND: Tumor Necrosis Factor-alpha (TNF-α) is a pro-inflammatory cytokine that plays a role in immune response against tuberculosis (TB) infection. Polymorphism in TNF-α gene may be associated with susceptibility to pulmonary TB (PTB). AIM: The purpose of this study was to investigate whether TNF-α-308G/A gene polymorphism is associated with susceptibility to PTB in Medan city, Indonesia. METHODS: This is a case–control study with 100 PTB patients and 100 healthy control. TNF-α polymorphism genotyping was performed by polymerase chain reaction fragment length polymorphism method. RESULTS: There were 200 participants enrolled in this study. Most of the participants were male and were in the age range of 20–39 years. Genotyping examination revealed that in the TB group, AG and GG genotype was found in 80 people (80%) and 20 people (20%), respectively. There were no TB patients with AA genotypes. Whereas, in the control group, subjects with AA, AG, and GG genotypes were 2 (2%), 47 (47%), and 51 (51%), respectively. Statistical analysis showed that there was a significant relationship between TNF-α-308 G/A polymorphism and PTB, in which individuals with AG genotypes were 4.3 times more likely to suffer PTB compared to GG genotype (p < 0.001, 95% confidence interval (CI) 2.31–8.15). Further analysis showed that A allele increased the risk of TB incidence by 1.94-fold compared to the G allele (p = 0.002, 95% CI 1.27–2.98). CONCLUSIONS: There was a significant relationship between TNFα-308 G/A gene polymorphism and the susceptibility to PTB and A allele increases the risk of pulmonary TB compared to G allele.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

Sinaga

Amir

2021

Open Access Maced J Med Sci

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TNF-α gene polymorphism in Iranian Azeri population

et al. 2020

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IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran

Asgharzadeh

Najafi-Ghalehlou

Poor

et al. 2021

EMIDDT

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Background: Cytokines are polypeptides that play critical roles in immune responses. Gene polymorphisms occurring in the inflammatory cytokines are taking role in autoimmune diseases, including multiple sclerosis (MS), which may induce inappropriate immune responses. Objective: The aim of this study was to investigate the allelic and genotypic frequencies of interferon gamma gene (IFN-γ) at +874A/T locus and tumor necrosis factor (TNF-α) at+308A/G locus in MS patients of Azeri population. Methods: At first, a questionnaire was prepared for each of 240 healthy, non-relative, and 152 Azeri MS patients before obtaining the blood sample from all subjects. After DNA extraction, the frequency of alleles and genotypes of the IFN-γ and TNF-α genes at +874A/T and -308G/A loci, respectively, were determined by allele-specific PCR method. Finally, the frequencies were compared between control and MS patients by chi-square test (x2 -test) and p<0.05 was considered significant. Results: In the IFN-γ +874A/T gene single nucleotide polymorphism (SNP), the most allelic and genotypic frequencies in MS patients were the A allele, 55.26% (p=0.04) and the AT genotype, 52.63% (p=0.048). In healthy individuals, it was 65.42% for the A allele and 45.42% for the AA genotype. For the TNF-α 308 G/A SNP, the highest allelic and genotypic frequencies in MS patients were the G allele with 55.92% (p<0.001) and AG genotype with 61.84%, and in healthy subjects, the allelic and genotypic frequencies were 84.2% and 70.8% for the G allele and GG genotype, respectively. Conclusion: Head trauma, the infection with herpes virus and Mycoplasma pneumonia, frequent colds and high consumption of canned foods provide grounds for MS. The T allele in the IFN-γ gene (+874) and the genotypes of AA and AG at the TNF-α gene (-308) at the position-308 were considered as potential risk factors for MS. Therefore, the polymorphisms in cytokine genes and following changes in their expression levels can be effective in susceptibility to MS.

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TNF-α -308G/A polymorphism and susceptibility to tuberculosis in Azeri population of Iran

Cited by 3 publications

References 21 publications

Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

Tumor Necrosis Factor-alpha -308G/A Polymorphism Associated with Increased Risk for Pulmonary Tuberculosis in Medan City, Indonesia

TNF-α gene polymorphism in Iranian Azeri population

IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran

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