TLR2 Signaling Pathway in Alveolar Bone Osteogenesis Induced by Aloe vera and Xenograft (XCB)

Kresnoadi, Utari; Rahayu, Retno Pudji; Rubianto, Mohamad; Sudarmo, Subijanto Marto; Budi, Hendrik Setia

doi:10.1590/0103-6440201600834

Cited by 13 publications

(21 citation statements)

References 15 publications

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“…24 Similarly, research conducted by Kresnoadi et al also revealed that the number of osteoblasts on day 30 increase significantly compared to the previous day. 25 In conclusion, the post-extraction preservation of sockets using a combination of Moringa oleifera leaf extract and DFBBX may increase the activity of alveolar bone formation as indicated by an increase in type 1 collagen expressions. The selection of materials used in the preservation of tooth extraction sockets, nevertheless, plays an important role in the process of bone formation.…”

Section: Discussionmentioning

confidence: 89%

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

Soekobagiono¹,

Salim²,

Hidayati³

et al. 2018

Dent. J.

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Background: Tooth extraction is a common procedure in dentistry after which the residual ridge will no longer receive stimulus leading to volume, height and width loss. These anatomical changes can then result in difficulties with future denture fabrication and implant placement. Preservation of the alveolar ridge, therefore, assumes considerable importance after tooth extraction. Moringa oleifera, on the other hand, can enhance bone formation. Type-1 collagen is a marker of osteoblast formation. Purpose: This research aimed to analyze the effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressions in tooth extraction sockets. Methods: 56 Cavia cobaya subjects were divided into eight groups. Their lower left incisors were then extracted prior to the sockets of the first and fifth groups being filled with PEG, those of the second and sixth groups with DFBBX, those of the third and seventh groups with Moringa oleifera leaf extract and a combination of DFBBX and Moringa oleifera leaf extract in those of the fourth and eighth groups. The sockets were then examined on days 7 and 30 by means of an immunohistochemical technique. The data collected was subsequently subjected to analysis by One Way Anova and Tukey HSD tests. Results: There were significant differences between the control group and the treatment group administrated with Moringa oleifera leaf extract combined with DFBBX. On days 7 and 30, the groups treated with the combination of DFBBX and Moringa oleifera leaf extract had the highest number of type-1 collagen expressions. Conclusion: A combination of DFBBX and Moringa oleifera leaf extract is effective in increasing type-1 collagen expressions in tooth extraction sockets.

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Section: Discussionmentioning

confidence: 89%

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

Soekobagiono¹,

Salim²,

Hidayati³

et al. 2018

Dent. J.

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“…The C. cobaya were first anesthetized intramuscularly using 0.2 cc ketamine (20 mg/300 mg). [ 16 ] Each participant's left mandibular incisor was then cleared of food scraps with a water spray and dried before being extracted. In the next stage, approximately 0.1 ml of a combination of Moringa leaf extract, DFDBBX (Bonegraft 10 mesh/2000 μ, Batan) and PEG was introduced into the sockets by syringe.…”

Section: Methodsmentioning

confidence: 99%

The role of the combination of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft (xenograft) as tooth extraction socket preservation materials on osteocalcin and transforming growth factor-beta 1 expressions in alveolar bone of Cavia cobaya

Kresnoadi¹,

Rahmania²,

Caesar³

et al. 2019

J Indian Prosthodont Soc

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Aim: Alveolar bone resorption, often occurring after tooth extraction, can be minimized through socket preservation. This process uses a combination of Moringa leaf extract and demineralized freeze-dried bovine bone xenograft (DFDBBX) that is expected to generate both transforming growth factor-beta 1 (TGF-β1) expressions as a transcription factor associated with osteoblast differentiation and osteocalcin accelerating alveolar bone formation. This research aimed to analyze the role of the combination of Moringa leaf extract and DFDBBX induced in socket preservation when generating TGF-β1 and osteocalcin expressions. Materials and Methods: The left mandibular incisors of 56 Cavia cobaya were extracted and divided into four groups subjected to different socket preservation treatments. The first group treated with polyethylene glycol, the second group with DFDBBX, the third group with Moringa leaf extract, and the fourth group with a combination of DFDBBX and Moringa leaf extract. The C. cobaya were examined on days 7 and 30, after which the specimens were sacrificed and examined using an immunohistochemical technique. The resulting data were then analyzed using one-way ANOVA and Tukey's honestly significant difference tests. Results: There was a significant difference in TGF-β1 and osteocalcin expressions between the groups ( P < 0.05). The highest mean amount of TGF-β1 and osteocalcin was found in the fourth group on both days 7 and 30. Conclusions: The combination of Moringa leaf extract and DFDBBX can effectively generate TGF-β1 and osteocalcin expressions during the preservation of tooth extraction sockets.

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“…The anthraquinone glycoside content called emodin in Aloe vera extract suppresses bone resorption activity from osteoclasts by inhibiting RANKL [9]. It has been demonstrated that there was an increase in the number of osteoclasts in the untreated extraction group and in the group with filling mixture Aloe vera there was a significant decrease in the number of osteoclasts in the group 14 days after extraction and group 30 days and the most decrease in the group 60 days after extraction [6].…”

Section: Discussionmentioning

confidence: 99%

“…Anthraquinone has several beneficial properties such as anti-inflammatory, analgesic, anti-microbial effects, and anesthetics, and laxative effects. It is also known that aloe-emodin can improve tissue healing and healing processes and minimizes pain [6].…”

Section: Introductionmentioning

confidence: 99%

Histometry Analysis of Osteoclasts, Osteoblasts and Fibroblasts in Immediate Placement Implants with Addition of Aloe Vera Extract

Machmud

Jubhari

Ardiansyah

2019

Pesqui. bras. odontopediatria clín. integr.

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Objective: To analyze the effect of immediate placement of implants with extract from the new bone formation histometically. Material and Methods: In this true-experimental design with randomized post test control group, 9 mongrel dogs weighing 10 to 12 kg were used, which were divided into 3 groups, based on observation time of 14 days, 28 days and 56 days. On the installation of implants (∅3.5x10 mm) sequentially, the former socket extraction of the lower jaw's right second premolar tooth in the study sample injected 10% Aloe vera gel extract and left second left premolar tooth without injection of 10% Aloe vera extract. To compare independent groups use the Mann-Whitney test. All analysis were carried out using SPSS version 20. Results: There was an increase in the number of osteoblast cells in both treatment and control groups, but the value of the treatment group was greater. There were significant differences in the number of osteoblast cells between the treatment and control groups 14 days (p=0.019), 28 days: (p=0.018), and 56 days (p=0.009). There were no significant differences in the number of fibroblast cells between the treatment and control groups (p>0.05). But at observations 28 and 56 days, it was showed a significant difference in the number of fibroblast cells between the treatment and control groups (p=0.353 and p=0.024, respectively). Conclusion: Immediate placement of implants with 10% Aloe vera extract gel on extracted socket increases the number of osteoblasts and suppresses the number of osteoclasts and fibroblasts.

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TLR2 Signaling Pathway in Alveolar Bone Osteogenesis Induced by Aloe vera and Xenograft (XCB)

Cited by 13 publications

References 15 publications

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

Effects of Moringa oleifera leaf extract combined with DFBBX on type-1 collagen expressed by osteoblasts in the tooth extraction sockets of Cavia cobaya

The role of the combination of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft (xenograft) as tooth extraction socket preservation materials on osteocalcin and transforming growth factor-beta 1 expressions in alveolar bone of Cavia cobaya

Histometry Analysis of Osteoclasts, Osteoblasts and Fibroblasts in Immediate Placement Implants with Addition of Aloe Vera Extract

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