Titanium surface interacting with clot network and entrapped blood components promotes migration and osteogenic differentiation of bone marrow mesenchymal stem cells
Abstract:Background : A series of biological events was initiated upon the implantation placement, beginning with blood-material contact, followed by coagulation cascade, blood clot formation and bone marrow mesenchymal stromal cells (BMSCs) recruitment. Aim/Hypothesis : The aim of this study was to investigate the effect of implant surface on blood-material interactions and subsequent rBMSCs cellular behaviors via mimicking physiological process in vitro and in vivo. Materials and Methods : This study established in v… Show more
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