Tissue structure and blood microcirculation monitoring by speckle interferometry and full-field correlometry

Tuchin, Valery V.; Ryabukho, Vladimir P.; Zimnyakov, Dmitry A.; Lobachev, Mickail I.; Lyakin, D. V.; Radchenko, Elena Yu.; Chaussky, Anatoly A.; Konstantinov, K. V.

doi:10.1117/12.427886

Cited by 12 publications

(24 citation statements)

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“…For many tissues, µ t is much greater than (µ a + µ s ′). Therefore, in certain situations, it is impossible to detect pure ballistic photons (photons that do not experience scattering), but forward scattered photons retain their initial polarization and can be used for imaging purpose [5,9,10,[71][72][73][74][75][76][77]. There was experimentally demonstrated that laser radiation retains linear polarization on the level of P L ≤ 0.1 within 2.5l tr .…”

Section: Multiple Scatteringmentioning

confidence: 99%

“…The polarization imaging is a prospective direction in tissue optics [5,9,10,[71][72][73][74][75][76][77]. The registration of two-dimensional polarization patterns for the backscattering of a polarized incident narrow laser beam is the basis for this technique.…”

Section: Multiple Scatteringmentioning

confidence: 99%

“…Light of arbitrary polarization can be represented by four numbers known as the Stokes parameters, I, Q, U, and V: I -refers to the intensity of the light; the parameters Q, U, and V represent the extent of horizontal liner, 45º linear, and circular polarization, respectively [5,9,56,[62][63][64][65][66][67][68][69][70][71]. In terms of the electric field components the Stokes parameters are given by (3.93) and the irradiance or intensity of light by…”

Section: Definitionsmentioning

confidence: 99%

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Tissue Optics and Photonics: Light-Tissue Interaction

Tuchin

2015

JBPE

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136

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Abstract. This is the second section of the review-tutorial paper describing fundamentals of tissue optics and photonics. As the first section of the paper was mostly devoted to description of biological tissue structures and their specificity related to interactions with light [1], this section 3 describes light-tissue interactions themselves that are caused by tissue dispersion, scattering, and absorption properties, including light reflection and refraction, absorption, elastic, and quasi-elastic scattering. The major tissue absorbers and modes of elastic scattering, including Rayleigh and Mie scattering, will be presented. © 2015 Samara State Aerospace University (SSAU).

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Section: Multiple Scatteringmentioning

confidence: 99%

Section: Multiple Scatteringmentioning

confidence: 99%

Section: Definitionsmentioning

confidence: 99%

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Tissue Optics and Photonics: Light-Tissue Interaction

Tuchin

2015

JBPE

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“…In particular, for the nucleus the refractive index is n nc = 1.39 [8], and for the cytoplasm n 0 = 1.35-1.37 [3]. The scattering particles (organelles, protein fibrils, membranes, and globules) have greater density of proteins and lipids and, hence, higher refractive index (n s = 1.39-1.47) in comparison with the base substance of the cytoplasm [6]. The refractive index values of the connective tissue fibrils lie in the range 1.41-1.53 and depend upon the degree of hydration of their major component, the collagen [9].…”

Section: Introduction: Fundamentals Of Optical Clearing Of Tissues Anmentioning

confidence: 99%

“…In fibrous tissues (stroma of eye sclera and cornea, dermis, dura mater, connective tissue of vascular walls, fibrous components of muscle tissue and mammary gland, cartilage, tendon, etc.) the scattering is caused by the refractive index difference between the interstitial fluid or cytoplasm and the extensive chains of scleroproteins (collagen, elastin, and reticulin fibrils) [3,6]. The refractive index values for nuclei and cytoplasm organelles of animal cells, containing nearly the same amount of proteins and nucleic acids, lie within the relatively narrow interval from 1.38 to 1.41 [7].…”

Section: Introduction: Fundamentals Of Optical Clearing Of Tissues Anmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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Abstract.A review of specific features and methods of optical clearing and related interaction of light with tissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular tissues are discussed. The possibility of efficient control of the tissue optical properties, particularly, the reduction of light scattering in tissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposes. © 2015 Samara State Aerospace University (SSAU).Keywords: tissue, optical clearing, optical diagnostics, imaging. 1, 404-413 (1997). 5. C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, "Penetration depth limits of in vivo confocal reflectance imaging," Appl. Opt. 37, 2749Opt. 37, -2754Opt. 37, (1998. 6. V. V. Tuchin, L. V. Wang, and D. A. Zimnyakov, Optical Polarization in Biomedical Applications, SpringerVerlag, New York, NY, USA (2006). 7. R. Drezek, A. Dunn, and R. Richards-Kortum, "Light scattering from cells: finite-difference time-domain simulations and goniometric measurements," Appl. Opt. 38(16), 3651-3661 (1999). 8. K. Sokolov, R. Drezek, K. Gossagee, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light:is it sensitive to cellular and nuclear morphology," Opt. Express 5, 302-317 (1999). 9. D. W. Leonard, and K. M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," Biophysical J. 72, 1382-1387 (1997). 10. A. G. Borovoi, E. I. Naats, and U. G. Oppel, "Scattering of light by a red blood cell," J. Biomed. Opt. 3, 364-372 (1998). 11. A. N. Yaroslavsky, A. V. Priezzhev, J. Rodriguez, I. V. Yaroslavsky, and H. Battarbee, "Optics of blood,"Chap. 2 in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, Ed., pp. 169-216, PM107 SPIE Press, Bellingham, WA, USA (2002). 12. G. Mazarevica, T. Freivalds, and A. Jurka, "Properties of erythrocyte light refraction in diabetic patients," J.Biomed. Opt. 7, 244-247 (2002). 13. M. Friebel, and M. Meinke, "Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration," Appl. Opt. 45(12), 2838-2842 (2006). Appl. Opt. 35(19), 3413-3420 (1996). 34. D. Zhu, J. Wang, Z. Zhi, X. Wen, and Q. Luo, "Imaging dermal blood flow through the intact rat skin with an optical clearing method," J. Biomed. Opt. 15, 026008 (2010 241. K. König, G. Flemming, and R. Hibst, "Laser-induced autofluorescence spectroscopy of dental caries lesion," Cell. Mol. Biol. 44, 1293-1300. 242. E. G. Borisova, T. T. Uzunov, and L. A. Avramov, "Early differentiation between caries and tooth demineralization using laser-induced autofluorescence spectroscopy," Lasers Surg. Med. 34, 249-253 (2004 -20(12), 1512-1516 (1984). 245. K. Konig, H. Schneckenburger, and R. Hibst, "Time-gated in vivo autofluorescence imaging of dental caries,"Cell. Mol. Biol. 45, 233-239 (1999). 246. E. Borisova, P. Tr...

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Mueller matrix decomposition for polarized light assessment of biological tissues

Ghosh¹,

Wood²,

Li³

et al. 2009

Journal of Biophotonics

150

117

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The Mueller matrix represents the transfer function of an optical system in its interactions with polarized light and its elements relate to specific biologically or clinically relevant properties. However, when many optical polarization effects occur simultaneously, the resulting matrix elements represent several "lumped" effects, thus hindering their unique interpretation. Currently, no methods exist to extract these individual properties in turbid media. Here, we present a novel application of a Mueller matrix decomposition methodology that achieves this objective. The methodology is validated theoretically via a novel polarized-light propagation model, and experimentally in tissue simulating phantoms. The potential of the approach is explored for two specific biomedical applications: monitoring of changes in myocardial tissues following regenerative stem cell therapy, through birefringence-induced retardation of the light's linear and circular polarizations, and non-invasive blood glucose measurements through chirality-induced rotation of the light's linear polarization. Results demonstrate potential for both applications.

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Tissue structure and blood microcirculation monitoring by speckle interferometry and full-field correlometry

Cited by 12 publications

References 0 publications

Tissue Optics and Photonics: Light-Tissue Interaction

Tissue Optics and Photonics: Light-Tissue Interaction

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Mueller matrix decomposition for polarized light assessment of biological tissues

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