Tissue Engineering

Chiu, Loraine L. Y.; Chu, Zane E.; Radišić, Milica

doi:10.1016/b978-0-12-374396-1.00085-4

Cited by 8 publications

(5 citation statements)

References 202 publications

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“…Reproduced from [39]. CC BY 4.0. delivered cells via facilitating access to oxygen and nutrients, but also increases surface area for endogenous cell attachment [57]. This, in turn, would likely accelerate wound healing and skin tissue regeneration.…”

Section: Clinical Delivery Methodsmentioning

confidence: 99%

Point of care approaches to 3D bioprinting for wound healing applications

et al. 2023

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In the quest to improve both aesthetic and functional outcomes for patients, the clinical care of full-thickness cutaneous wounds has undergone significant development over the past decade. A shift from replacement to regeneration has prompted the development of skin substitute products, however, inaccurate replication of host tissue properties continues to stand in the way of realising the ultimate goal of scar-free healing. Advances in three dimensional (3D) bioprinting and biomaterials used for tissue engineering have converged in recent years to present opportunities to progress this field. However, many of the proposed bioprinting strategies for wound healing involve lengthy in-vitro cell culture and construct maturation periods, employ complex deposition technologies, and lack credible point of care (POC) delivery protocols. In-situ bioprinting is an alternative strategy which can combat these challenges. In order to survive the journey to bedside, printing protocols must be curated, and biomaterials/cells selected which facilitate intraoperative delivery. In this review, the current status of in-situ 3D bioprinting systems for wound healing applications is discussed, highlighting the delivery methods employed, biomaterials/cellular components utilised and anticipated translational challenges. We believe that with the growth of collaborative networks between researchers, clinicians, commercial, ethical, and regulatory experts, in-situ 3D bioprinting has the potential to transform POC wound care treatment.

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Section: Clinical Delivery Methodsmentioning

confidence: 99%

Point of care approaches to 3D bioprinting for wound healing applications

et al. 2023

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“…Essentially, these can be divided structurally into porous scaffolds, fibrous scaffolds, and hydrogels, where hydrogels are primarily used in the field of pulp biology research. They best imitate the mechanical properties of the dental pulp, and furthermore, their injectability makes them suitable for use in the root canal [47,48]. Appropriate materials should restore tissue architecture and guide cell growth but also degrade over time to provide space for new tissue formation [48,49].…”

Section: Hydrogelsmentioning

confidence: 99%

A Compilation of Study Models for Dental Pulp Regeneration

Ohlsson

Galler

Widbiller

2022

IJMS

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Efforts to heal damaged pulp tissue through tissue engineering have produced positive results in pilot trials. However, the differentiation between real regeneration and mere repair is not possible through clinical measures. Therefore, preclinical study models are still of great importance, both to gain insights into treatment outcomes on tissue and cell levels and to develop further concepts for dental pulp regeneration. This review aims at compiling information about different in vitro and in vivo ectopic, semiorthotopic, and orthotopic models. In this context, the differences between monolayer and three-dimensional cell cultures are discussed, a semiorthotopic transplantation model is introduced as an in vivo model for dental pulp regeneration, and finally, different animal models used for in vivo orthotopic investigations are presented.

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“…So the use of a scaffold to serve as temporary matrix and provide structural support for the cells to attach, proliferate and differentiate is an approach in tissue engineering. Therefore, an ideal scaffold should mimic the advantageous properties of the natural ECM [1][2][3] and have porous structure, biocompatibility with the cells, appropriate mechanical strength and biodegradation rate [4]. To achieve these desired properties it is vital to use biomaterials which can be divided into broad categories of synthetic or naturally derived.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Nano Calcium Phosphate via Biomimetic Method for Bone Tissue Engineering Scaffolds and Investigation of its Phase Transformation in Simulated Body Fluid

Raz

Moztarzadeh

Shokrgozar

et al. 2013

KEM

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In this study the formation of calcium phosphate phase via double diffusion method into a hydrogel matrix was investigated and its phase transformation in simulated body fluid was studied. White precipitate was formed within the hydrogel, due to the diffusion of calcium and phosphate ions through the hydrogel matrix in similar pH to human body. Phase composition, microstructure and structural groups in the composite samples were also characterized by X-Ray Diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infra-red (FTIR) analyses. Microstructure of precipitates formed within middle hydrogel, showed that detected materials are composed of carbonated hydroxyapatite and dicalcium phosphate dihydrate (DCPD, brushite). The particle size was about 10 nm .Analysis results showed that after incubation in simulated body fluid, dicalcium phosphate dehydrate phase transformed into crystalline hydroxy apatite.

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Tissue Engineering

Cited by 8 publications

References 202 publications

Point of care approaches to 3D bioprinting for wound healing applications

Point of care approaches to 3D bioprinting for wound healing applications

A Compilation of Study Models for Dental Pulp Regeneration

Synthesis of Nano Calcium Phosphate via Biomimetic Method for Bone Tissue Engineering Scaffolds and Investigation of its Phase Transformation in Simulated Body Fluid

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