A Compilation of Study Models for Dental Pulp Regeneration

Ohlsson, Ella; Galler, Kerstin M.; Widbiller, Matthias

doi:10.3390/ijms232214361

Cited by 7 publications

(3 citation statements)

References 143 publications

(233 reference statements)

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“…Study models for pulp regeneration, as described by Ohlsson et al, can be categorized into in vitro, in vivo ectopic, in vivo semiorthotopic, and in vivo orthotopic approaches. These models encompass diverse strategies involving scaffold and cell transplantation in various animal contexts [42].…”

Section: Dental Pulp-dentin Regenerationmentioning

confidence: 99%

Advancing Dentistry through Bioprinting: Personalization of Oral Tissues

Shopova,

Mihaylova,

Yaneva

et al. 2023

JFB

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Despite significant advancements in dental tissue restoration and the use of prostheses for addressing tooth loss, the prevailing clinical approaches remain somewhat inadequate for replicating native dental tissue characteristics. The emergence of three-dimensional (3D) bioprinting offers a promising innovation within the fields of regenerative medicine and tissue engineering. This technology offers notable precision and efficiency, thereby introducing a fresh avenue for tissue regeneration. Unlike the traditional framework encompassing scaffolds, cells, and signaling factors, 3D bioprinting constitutes a contemporary addition to the arsenal of tissue engineering tools. The ongoing shift from conventional dentistry to a more personalized paradigm, principally under the guidance of bioprinting, is poised to exert a significant influence in the foreseeable future. This systematic review undertakes the task of aggregating and analyzing insights related to the application of bioprinting in the context of regenerative dentistry. Adhering to PRISMA guidelines, an exhaustive literature survey spanning the years 2019 to 2023 was performed across prominent databases including PubMed, Scopus, Google Scholar, and ScienceDirect. The landscape of regenerative dentistry has ushered in novel prospects for dentoalveolar treatments and personalized interventions. This review expounds on contemporary accomplishments and avenues for the regeneration of pulp—dentin, bone, periodontal tissues, and gingival tissues. The progressive strides achieved in the realm of bioprinting hold the potential to not only enhance the quality of life but also to catalyze transformative shifts within the domains of medical and dental practices.

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Section: Dental Pulp-dentin Regenerationmentioning

confidence: 99%

Advancing Dentistry through Bioprinting: Personalization of Oral Tissues

Shopova,

Mihaylova,

Yaneva

et al. 2023

JFB

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“…Dogs still represent a more reproducible and meaningful insight as their teeth pose high similarity to human anatomy [13,14]. In addition, the literature includes semi-orthotropic studies where safety, biological response, and e ectiveness could be evaluated in which the intervention of transplanting experimental samples is carried out either subcutaneously or inferior to the renal capsule [15].…”

Section: Translational Researchmentioning

confidence: 99%

Regenerative endodontics: repair or true regeneration? A narrative review

2023

OHMR

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Regenerative endodontics therapy (RET) is a pioneering approach in dentistry that aims to restore damaged dental pulp and promote tissue regeneration in non-vital teeth. It belongs to the broader field of regenerative medicine, where stem cells, scaffolds, and bioactive molecules are central components. The goal of RET is to achieve true tissue regeneration, fully restoring both the structure and function of damaged tissues, in contrast to repair, which only restores basic functionality through scar formation or tissue remodeling. Histological studies conducted in various research models, ranging from animal studies to human case studies, have provided valuable insights into the nature of tissue regeneration in RET. However, the quality of regenerated tissue can vary significantly among studies. Some research reports have described the presence of fibrous or fibrovascular tissue with limited functionality, resembling repair rather than true regeneration. This variation can be attributed to the impact of disinfection protocols on stem cell viability and differentiation potential. In conclusion, RET has the potential for both repair and true regeneration processes, with outcomes influenced by factors such as disinfection methods and the source of stem cells. Despite the remaining challenges, promising results suggest that RET could revolutionize dental pulp regeneration, especially when approaches that utilize the body\'s stem cells are optimized for clinical use. Further research and protocol refinement is essential to fully unlock the regenerative potential of this exciting field.

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“…Ohlsson et al have undertaken a comprehensive compilation of preclinical study models [18]. Their review provides an overview of various ectopic, semi-orthotopic, and orthotopic in vitro and in vivo models to investigate regenerative endodontics.…”

Section: Figurementioning

confidence: 99%