Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia

Omari‐Siaw, Emmanuel; Wang, Qilong; Sun, Congyong; Gu, Zengquan; Zhu, Yuan; Cao, Xia; Firempong, Caleb Kesse; Agyare, Rita; Xu, Ximing; Yu, Jiangnan

doi:10.1016/j.ijpharm.2016.08.042

Cited by 40 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A single intraperitoneal (i.p.) injection of P407 at a dose of 300 mg/kg can readily produce significant hyperlipidemia within approximately 4 days (Omari‐Siaw, Wang, et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…Hyperlipidemia is a systemic metabolic disorder that is usually caused by unhealthy diet intake. It is characterized by abnormally elevated levels of total cholesterol (TC), triglyceride (TG), low‐density lipoprotein cholesterol (LDL‐c), but decreased concentration of high‐density lipoprotein cholesterol (HDL‐c) in serum (Mao et al, ; Omari‐Siaw, Wang, et al, ). Hyperlipidemia is closely associated with many diseases, such as cardiovascular diseases (Omari‐Siaw, Zhu, et al, ), fatty liver (Leutner et al, ), and diabetes mellitus (Liu, Sun, Rao, Su, & Yang, ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Deng

Yang

Zhu

et al. 2019

Food Science & Nutrition

Self Cite

View full text Add to dashboard Cite

This study aimed to investigate structural features and antihyperlipidemic effects of the stigma maydis polysaccharide, termed SMP‐1. This polysaccharide was composed of D‐mannose, L‐rhamnose, D‐glucose, D‐galactose, L‐arabinose, D‐xylose, and D‐galacturonic acid, with a molar ratio of 1.00:0.21:1.41:1.44:0.70:0.44:0.56. The SMP‐1 was mainly bonded by (1 → 6) and (1 → 3) linkages, with various monosaccharides being evenly distributed in the main and side chains. Moreover, SMP‐1 had neither triple‐helical structure nor molecular aggregation. Importantly, the SMP‐1 could effectively bind the bile acids in vitro and significantly lower the total cholesterol, triglyceride, low‐density lipoprotein cholesterol levels, and moderately increase the high‐density lipoprotein cholesterol level in poloxamer 407‐induced hyperlipidemic mice. Moreover, pretreatment with SMP‐1 (≥300 mg/kg) could remarkably reduce fat accumulation and restore hepatocyte morphology in the liver of hyperlipidemic mice. Altogether, these findings indicated that SMP‐1 could be developed as a safe and effective food supplement for preventing and treating hyperlipidemic disorders.

show abstract

“…A single intraperitoneal (i.p.) injection of P407 at a dose of 300 mg/kg can readily produce significant hyperlipidemia within approximately 4 days (Omari‐Siaw, Wang, et al, ).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Deng

Yang

Zhu

et al. 2019

Food Science & Nutrition

Self Cite

View full text Add to dashboard Cite

show abstract

“…Oxidative free radicals are associated with lipid peroxidation, which leads to vascular endothelial damage, and is associated with atherosclerosis [24]. In the process of production of oxidized lipids, malondialdehyde (MDA) is the product of polyunsaturated fatty acids and an active oxygen reaction [25].…”

Section: Introductionmentioning

confidence: 99%

Effects of an Enriched Extract of Paeoniflorin, a Monoterpene Glycoside used in Chinese Herbal Medicine, on Cholesterol Metabolism in a Hyperlipidemic Rat Model

Zhu

Shi

et al. 2017

Med Sci Monit

View full text Add to dashboard Cite

BackgroundPaeoniflorin is a monoterpene glycoside extracted from the roots of Paeonia lactiflora and is used in Chinese herbal medicine to treat hyperlipidemia. The aim of this study was to evaluate the effects of an enriched extract of paeoniflorin on cholesterol levels, hemodynamics, and oxidative stress in a hyperlipidemic rat model.Material/MethodsMale Sprague-Dawley rats were fed high-cholesterol diets and treated with three different doses of paeoniflorin for 12 weeks. The effects of paeoniflorin treatment were assessed on cholesterol levels, cholesterol metabolism, red blood cell vascular flow using hemorheology, antioxidant enzymes, and expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR). Rat liver histology and immunohistochemical analysis were performed to evaluate the expression of nuclear factor erythroid 2–related factor 2 (Nrf2), cytochrome P450 7A1 (CYP7A1), and peroxisome proliferator-activated receptors (PPAR)-α. Protein expression HMG-CoAR, low-density lipoprotein receptor (LDLR), PPAR-α and CYP7A1 was measured by Western blotting. Antioxidant activity in rat liver was determined by measuring superoxide dismutase (SOD) and malondialdehyde (MDA).ResultsSerum and hepatic cholesterol, hepatic steatosis and the products of cholesterol metabolism were reduced by paeoniflorin treatment, which also reduced the activity of HMG-CoAR and upregulated the expression of LDLR, PPAR-α, and CYP7A1 expression, increased SOD, decreased MDA, and upregulated Nrf2 expression.ConclusionsThe findings of this study in a rat model of hyperlipidemia have shown that paeoniflorin regulates hepatic cholesterol synthesis and metabolism and may also protect the liver from oxidative stress.

show abstract

“…Twenty‐four (24) hours after i.p. injection of P‐407 (Omari‐Siaw et al ., ), following a 12‐h fast with free access to water, blood samples were obtained from the orbital vein into a heparin‐coated tube and centrifuged at 2656 g for 10 min at 4 °C to obtain serum.…”

Section: Methodsmentioning

confidence: 99%

Chemical characterisation and hypolipidaemic effects of two purified Pleurotus eryngii polysaccharides

Xing

Wang

Yang

et al. 2018

Int J of Food Sci Tech

Self Cite

View full text Add to dashboard Cite

Summary This study is focused on the isolation and characterisation of two purified polysaccharide fractions (namely PPEP‐1 and PPEP‐2) from Pleurotus eryngii (P. eryngii) and evaluation of their hypolipidaemic effects. The Congo red analysis indicated that PPEP‐2 but not PPEP‐1 possessed a triple‐helix conformation. The atomic force microscope analysis revealed that PPEP‐1 and PPEP‐2 showed different polysaccharide chain conformations. Importantly, the mice treated with PPEP‐1 showed significantly lowered serum levels of total cholesterol (TC), triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐c) and increased high‐density lipoprotein cholesterol when compared with the hyperlipidaemia mice induced by the high‐fat diet. However, PPEP‐2 revealed less hypolipidaemic effect than PPEP‐1. Additionally, both PPEP‐1 and PPEP‐2 demonstrated remarkable hypolipidaemic effects by decreasing levels of serum TC, TG and LDL‐c in the hyperlipidaemic model induced by P‐407. Taken together, our findings suggest that the P. eryngii polysaccharides, especially PPEP‐1, could be developed as a natural functional food supplement for preventing hyperlipidaemia.

show abstract

Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia

Cited by 40 publications

References 34 publications

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Effects of an Enriched Extract of Paeoniflorin, a Monoterpene Glycoside used in Chinese Herbal Medicine, on Cholesterol Metabolism in a Hyperlipidemic Rat Model

Chemical characterisation and hypolipidaemic effects of two purified Pleurotus eryngii polysaccharides

Contact Info

Product

Resources

About