TiO2 assisted photocatalytic degradation of macrolide antibiotics

Babić, Sandra; Ćurković, Lidija; Ljubas, Davor; Čizmić, Mirta

doi:10.1016/j.cogsc.2017.05.004

Cited by 45 publications

(12 citation statements)

References 41 publications

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“…None of the reported degradation products (DPs) were identified in blanks or in standard solutions. There is a lack of research considering the degradation of macrolides, especially azithromycin, with advanced oxidation processes [14,15]. To our present knowledge, the photocatalytic degradation of azithromycin in simulated real conditions and degradation products formed after such degradation has not yet been reported.…”

Section: Resultsmentioning

confidence: 99%

Photocatalytic Degradation of Azithromycin by Nanostructured TiO2 Film: Kinetics, Degradation Products, and Toxicity

et al. 2019

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In this paper, nanostructured TiO2 film was prepared by the by sol-gel process and dip-coating technique with titanium tetraisopropoxide as a precursor. After heat treatment at 550 °C, the deposited film was characterized by means of micro-Raman spectroscopy and atomic force microscopy (AFM). It was found that the TiO2 film consisted of only the TiO2 anatase phase and showed a granular microstructure. Photocatalytic degradation of azithromycin by using sol-gel nanostructured TiO2 film was studied to define the most effective degradation process for potential use in wastewater treatment. Different factors were evaluated during photocatalysis, such as pH (3, 7, and 10), water matrix (ultrapure water and synthetic municipal waste water effluent), influence of another pharmaceutically active compound (sulfamethoxazole, one of the most often detected pharmaceutic compounds in waste waters), and radiation sources (low pressure ultraviolet (UV) mercury lamps with a UV-A and UV-C range; a light-emitting diode (LED) lamp with a radiation peak at 365 nm). The most effective degradation process was achieved with the UV-C irradiation source in matrices at pH 10. The water matrix had little effect on the photocatalytic degradation rates of azithromycin. The presence of sulfamethoxazole in the water matrix decreased the degradation rate of azithromycin, however, only in matrices with a pH level adjusted to 10. During the experiments, five azithromycin degradation products were identified and none of them showed toxic properties, suggesting effective removal of azithromycin. LED 365 nm as the irradiation source was not as effective as the UV-C lamp. Nevertheless, considering the cost, energy efficiency, and environmental aspects of the irradiation source, the LED lamp could be a “real-life” alternative.

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Section: Resultsmentioning

confidence: 99%

Photocatalytic Degradation of Azithromycin by Nanostructured TiO2 Film: Kinetics, Degradation Products, and Toxicity

et al. 2019

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“…Other studies have used photocatalysis to successfully degrade Flumequine [37][38][39][40][41]. Others have focused on the photocatalytic degradation of Clarithromycin and reported low degradation efficiencies [42][43][44][45][46].…”

Section: Recent Studies Have Demonstrated the Feasibility Of Flumequimentioning

confidence: 99%

Study of a photocatalytic process for removal of antibiotics from wastewater in a falling film photoreactor: Scavenger study and process intensification feasibility

Lou¹,

Kane

Wolbert

et al. 2017

Chemical Engineering and Processing: Process Intensification

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International audienceThis study focused on the removal of antibiotic by coupling of heterogeneous photocatalysis with ozonation and hydrogen peroxide. The main objective was to intensify the efficiency of photocatalytic activity for better and faster antibiotic elimination/mineralization in wastewater. To fulfill this purpose a photocatalytic process based on falling film reactor was designed and optimized. The effects of operating parameters such as wastewater flow rate in the falling film reactor, the presence of an oxidizing agent (H2O2 and O3), inlet concentrations, including catalyst dosage and light intensity were investigated and discussed. Experiments were mainly conducted with Flumequine and Clarithromycin. The first molecule (Flumequine) will serve as an example of fluoroquinolone antibiotics and the second (Clarithromycin) as an example of macrolide antibiotics. Experimentally, the results have shown interesting degradation and mineralization efficiency (on the order of 94% for degradation and 76% for mineralization). Evidence for redox catalysis was shown using X-ray photoelectron spectroscopy (XPS) before and after pollutant degradation. Moreover, special attention was also paid to identify the reaction products and the plausible degradation pathway during Flumequine degradation

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“…Azithromycin (C 38 H 72 N 2 O 12, AZT) is a broad-spectrum macrolide antibiotic employed in the treatment of different types of respiratory, gastric, and sexually transmitted diseases [4]. This has promoted not only its extensive use but also that its presence in the effluents of wastewater treatment plants and different natural bodies of water has been reported [5].…”

Section: Introductionmentioning

confidence: 99%

Potential application of persulfate and simulated sunlight radiation on azithromycin removal

Ospino-Atehortúa

Zúñiga-Benítez

Peñuela

2020

Environmental Engineering Research

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Azithromycin (AZT) is a macrolide antibiotic whose presence in different bodies of water has been reported. This implies that conventional treatment systems are not able for AZT removal. This paper presents the main results regarding the potential use of simulated sunlight and persulfate (PS) on the removal of AZT. The effects of the solution pH and the concentration of PS were evaluated considering a face centered, central composite experimental design. Under optimized experimental conditions, it was possible to reach an AZT elimination around 70.0%, and ~30.0% reduction of the total organic matter after 120 min of reaction. Additionally, it was established that basic pH conditions favor AZT removal, and high doses of PS could have an inhibitory effect on the reaction due to a radical scavenging phenomenon. The roles of SO4-• and OH• radicals on the reaction were evaluated by conducting tests under the presence of ethanol and tert-Butyl alcohol. In this manner, OH• radicals seem to be the main oxidizing species of AZT. Finally, the evaluation of the effect of the initial pollutant concentration allowed to establish that a pseudo first-order reaction kinetics model can be used to describe the AZT elimination under the evaluated experimental conditions.

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TiO2 assisted photocatalytic degradation of macrolide antibiotics

Cited by 45 publications

References 41 publications

Photocatalytic Degradation of Azithromycin by Nanostructured TiO2 Film: Kinetics, Degradation Products, and Toxicity

Photocatalytic Degradation of Azithromycin by Nanostructured TiO2 Film: Kinetics, Degradation Products, and Toxicity

Study of a photocatalytic process for removal of antibiotics from wastewater in a falling film photoreactor: Scavenger study and process intensification feasibility

Potential application of persulfate and simulated sunlight radiation on azithromycin removal

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