Tincture of Benzoin: Clinical and Microbiological Implications of Reusable Containers

Abstract

At our institution, tincture of benzoin solution is commonly used as a topical adhesive agent. As a cost-saving practice, multiple-dose bottles are routinely used in the operating rooms and the clinic on multiple patients. Although clinically pathogenic organisms are known to be capable of survival in both benzoin and its isopropyl alcohol solvent, no prior controlled studies have investigated the potential for tincture of benzoin solution to support the growth of specific pathogens under clinically relevant conditions. In this study, multiple aerobic, anaerobic, and spore-forming bacteria were exposed to tincture of benzoin solution, as well as Candida albicans and Mycobacterium fortuitum. Bacillus cereus was the only index organism demonstrating a clear ability to survive a 15 minute incubation in tincture of benzoin, although 24 hours of exposure to tincture of benzoin resulted in no subsequent viable cultures of this organism after 72 hours of incubation. Thus although certain bacilli might, under ideal circumstances, remain viable and infectious within multiple-dose bottles of tincture of benzoin, the risk of causing iatrogenic infection appears to be rather minimal. Still, the use of multiple-dose dispensers of topical agents, particularly in surgical patients, should be carefully scrutinized for their clinical risk-to-economic benefit ratio.

The efficacy of tincture of benzoin compound in the management of extraction sockets of mesio‐angularly impacted mandibular third molars

“…Certain factors have been associated with the development of alveolar osteitis following mandibular third molar extraction. These factors include age, gender, medical history, oral contraceptives, pericoronitis, poor oral hygiene, smoking and type of impaction [11][12][13][14][15] . Other factors identified were surgical time and technique, surgeons' experience, anaesthetic technique, use of perioperative antibiotics, topical antiseptic and intrasocket medications [16][17][18][19][20][21] .…”

“…The TBC is a pathological product and technically a medical varnish, which forms a seal over raw tissues to protect wounds from ingress of bacteria. It possesses balsamic aroma, has adhesive and mild bactericidal properties, and when applied topically, protects the mucosa as an antiseptic.…”

Solubility of Benzoin in Six Monosolvents and in Some Binary Solvent Mixtures at Various Temperatures

“…Traditional Chinese medicine found that benzoin can lighten negative emotion such as anxiety, and in recent years, benzoin has attracted attention because of its other medical applications. − But little attention has been paid to the crystallization and purification of benzoin. As an important purification technology, solution crystallization is commonly applied to produce APIs (active pharmaceutical ingredients) with high quality in the pharmaceutical industry, and it is the key factor process that influences the quality of products, especially in crystal habit, yield, and crystal size.…”

Benzaldehyde (CAS 100-52-7)

“…Encontra-se presente nas bandagens adesivas e previnem o surgimento de alergias, e ainda pode ser aplicado em fissuras cutâneas, aftas e bolhas de febre como estíptico, antisséptico e no tratamento de bolhas. 51 Além disso, ainda pode ser aplicado como repelente de abelha. Sua função principal é a de conduzir as abelhas para fora das colmeias, enquanto ocorre o recolhimento do mel.…”