Timing Affects the Clinical Outcome of Adjunctive Systemic Antibiotic Therapy for Generalized Aggressive Periodontitis

Kaner, Doğan; Christan, C.; Dietrich, Thomas; Bernimoulin, Jean‐Pierre; Kleber, Bernd‐Michael; Friedmann, Anton

doi:10.1902/jop.2007.060437

Cited by 63 publications

(106 citation statements)

References 54 publications

(114 reference statements)

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“…The results indicate similar clinical parameters after 9 months of observation period. As previously reported, the best results seem to be obtained with systemic antibiotic administration in conjunction with or immediately after conventional therapy 45 .…”

Section: Local X Systemicsupporting

confidence: 58%

“…Kaner et al 45 analyzed the effect amoxicillin + metronidazole immediately after SRP or 3 months after initial therapy (including subgingival reinstrumentation at this stage for this group). The findings, after 6 months, indicated a further PD reduction and greatest gain in CAL on statistically significant in the group that received antibiotics immediately after SRP.…”

Section: Antibioticsmentioning

confidence: 99%

See 1 more Smart Citation

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Ayub

Júnior

Grisi

et al. 2015

RGO, Rev. Gaúch. Odontol.

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Aggressive periodontitis, a distinct clinical entity of periodontal disease, is characterized by a pronounced episodic and rapid destruction of periodontal tissues and may result in rapid and RESUMOA periodontite agressiva, uma entidade clínica distinta da doença periodontal, é caracterizada por uma pronunciada destruição episódica e rápida dos tecidos periodontais e pode resultar em perda rápida e precoce dos dentes. Alguns trabalhos têm mostrado que o debridamento mecânico convencional juntamente com higiene oral muitas vezes não é suficiente para o controle da doença. Apesar de não existir consenso, estudos recentes desta condição mostram efeitos benéficos de terapias auxiliares ou coadjuvantes como a administração de antimicrobianos sistêmicos e locais. Entre os coadjuvantes locais, a literatura apresenta os antissépticos, antibióticos e terapia fotodinâmica. Dentre os sistêmicos são representados os antibióticos e antiinflamatórios. Independentemente dos resultados apresentados por cada um deles, se reconhece a dificuldade em se estabelecer um protocolo único para todos os casos em função da resposta individual apresentada por cada paciente. O objetivo do presente estudo foi revisar os resultados atuais sobre administração de coadjuvantes químicos associados à terapia convencional em casos de periodontite agressiva e sugerir protocolos clínicos.Termos de indexação: Periodontite agressiva. Antibacterianos. Anti-infecciosos locais. Antissépticos bucais. Anti-inflamatórios. Fotoquimioterapia. and alveolar bone destruction and c) family concentration of cases. The diagnosis of AP requires the exclusion of systemic diseases that may harm the host defense and lead to premature teeth loss (periodontal manifestations of systemic diseases). Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspectsThe existence of particular forms of AP was also recognized based on specific clinical and lab characteristics: localized aggressive periodontitis (LAP) and generalized aggresssive periodontitis (GAP) 2 .A successful treatment of AP is dependent of early diagnosis, directing the therapy to the elimination or deletion of pathogens, providing a favorable

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Section: Local X Systemicsupporting

confidence: 58%

Section: Antibioticsmentioning

confidence: 99%

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Ayub

Júnior

Grisi

et al. 2015

RGO, Rev. Gaúch. Odontol.

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“…The recordings of the DMFT score for cariological status, mucosal alterations and temporomandibular dysfunction (TMD) followed the guidelines for oral health surveys of WHO [19]. In addition, a complete clinical periodontal status including probing pocket depth (PD) and clinical attachment level measurement (CAL) from six sites/tooth was performed with a pressure calibrated periodontal probe [20]. Oral hygiene was assessed by dental plaque present or not, according to O’Leary’s plaque control record [21] and bleeding on periodontal probing present or not, according to Ainamo and Bay [22].…”

Section: Methodsmentioning

confidence: 99%

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

et al. 2014

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Human leukocyte antigens (HLA) are crucial components of host defense against microbial challenge but the associations of HLA types with oral infectious diseases have not been studied in detail. This prospective cross-sectional study examined associations of HLA-A, -B and -DRB1 types with common oral diseases in a healthy Swiss adult population. 257 subjects (107 m, 150 f, mean age: 43.5 yr; range: 21–58 yr) with known HLA-A, -B and -DRB1 profiles and comprehensive medical records were included. A thorough anamnesis was followed by oral examinations including saliva flow measurements, the DMFT score for cariological status, complete periodontal status with plaque and bleeding indexes as well as assessment of mucosal alterations and temporomandibular dysfunction (TMD). Student’s t-test and Pearson chi-square test were utilized to compare the oral diseases between HLA positive and negative subjects. Bonferroni correction for multiple comparisons was used and PBonf<0.05 was considered statistically significant. HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) were associated with less periodontal disease manifestations. HLA-A32 had a positive association with TMD dysfunction (PBonf = 0.012). No other statistically significant associations were observed. In conclusion, HLA types may contribute to the development of oral diseases in generally healthy Caucasian adults.

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“…Each patient underwent periodontal pretreatment with systemic administration of Amoxicillin 250-500 mg(Novomox,cipla) eight hourly and with Metronidazole 200-400mg(Metrogyl) eight hourly for five days. [3][4][5][6] Each patient underwent initial therapy with removal of supra and sub gingival plaque and elimination of cofactors (projecting filling margins, carious lesions, etc.). This was supplemented by thorough instruction and motivation aimed at effective oral hygiene.…”

Section: Study Populationmentioning

confidence: 99%

Clinical Evaluation of Intrabony Defects in Localized Aggressive Periodontitis Patients with and without Bioglass- An In-vivo Study

Satyanarayana

Anuradha

Gadicherla

et al. 2012

Kathmandu Univ. Med. J.

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Background Aggressive periodontitis is a specific type of periodontitis with clearly identifiable clinical characteristics such as “rapid attachment loss, bone destruction” and “familial aggregation”. Regeneration of mineralized tissues affected by aggressive periodontitis comprises a major scientific and clinical challenge. In recent years some evidence has been provided that bioactive glass is also capable of supporting the regenerative healing of periodontal lesions. Objective The aim of this clinical and radiological prospective study was to evaluate the efficacy of bioactive glass in the treatment of intra-bony defects in patients with localized aggressive periodontitis. Methods Twelve localized aggressive periodontitis patients with bilaterally located three-walled intra-bony defect depth ? 2 mm, preoperative probing depths ? 5 mm were randomly treated either with the bioactive glass or without the bioactive glass. The clinical parameters plaque index, gingival index, probing depth, gingival recession, clinical attachment level, and mobility were recorded prior to surgery as well as 12 months after surgery. Intraoral radiographs were digitized to evaluate the bone defect depth at baseline and 12 months after the surgery. Results After 12 months, a reduction in probing depth of 3.92 + 0.313 mm (P <0.001) and a gain in clinical attachment level of 4.42+0358mm (P <0.001) were registered in the test group. In the control group, a reduction in probing depth of 2.5 +0.230mm (P <0.001) and a gain in clinical attachment level of 2.58 + 0.149 mm (P<0.001) was recorded. Radiographically, the defects were found to be filled by 2.587 + 0.218 mm (P <0.001) in the test group and by 0.1792 + 0.031mm (P <0.001) in the control group. Changes in gingival recession showed no significant differences. . Conclusion Highly significant improvements in the parameters Probing depth, Clinical attachment level, and Bone defect depth were recorded after 12 months, with regenerative material. KATHMANDU UNIVERSITY MEDICAL JOURNAL VOL.10 | NO. 1 | ISSUE 37 | JAN - MAR 2012 | 11-15 DOI: http://dx.doi.org/10.3126/kumj.v10i1.6906

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Timing Affects the Clinical Outcome of Adjunctive Systemic Antibiotic Therapy for Generalized Aggressive Periodontitis

Abstract: Within the limits of a retrospective analysis, these findings indicate that administration of amoxicillin/metronidazole immediately after initial SRP provides more PD reduction and RAL "gain" in initially deep sites than late administration at SPT with reinstrumentation after 3 months.

Cited by 63 publications

References 54 publications

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

Clinical Evaluation of Intrabony Defects in Localized Aggressive Periodontitis Patients with and without Bioglass- An In-vivo Study

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