Timescales of self-healing in human bone tissue and polymeric ionic liquids

Akbarzadeh, Johanna; Puchegger, S.; Stojanovic, Anja; Kirchner, H. O. K.; Binder, Wolfgang H.; Bernstorff, Sigrid; Zioupos, Peter; Peterlik, Herwig

doi:10.1680/bbn.14.00007

Cited by 15 publications

(12 citation statements)

References 33 publications

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“…In the framework of the thermally-activated plasticity model of bone deformation [37] referenced above, at strain rates lower than about 10-2 s-1, recovery aids deformation by defect repair, but this help becomes less and less effective as strain rates approach this value. Is to be noticed that this threshold strain rate at maximum fracture work is close to the relaxation rate r=1/75 s-1=1.33 10-2 s-1 obtained from the timescales of strain redistribution after fracture in collagen and mineral crystals within bone [38,39]. In this situation defect repair and hardening balance each other.…”

Section: Toughness Vs Strain Rate Figuresupporting

confidence: 70%

Ageing bone fractures: The case of a ductile to brittle transition that shifts with age

Zioupos

Kirchner

Peterlik

2020

Bone

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Human bone becomes increasingly brittle with ageing. Bones also fracture differently under slow and fast loadings, being ductile and brittle, respectively. The effects of a combination of these two factors have never been examined before. Here we show that cortical bone is most fracture-resistant at the physiologically prevalent intermediate strain rates of 10 -3 s -1 to 10 -2 s -1 such as they occur in walking or running, slightly weaker at slower quasistatic and much weaker at fast impact loading rates. In young cortical bone (15 years of age) the ductile-to-brittle transition (DBT) occurs at strain rates of 10 -2 s -1 , in old cortical bone (85 yrs) at speeds lower by a factor of 10 to 40. Other research has shown that the energy required to break bone (per unit of fracture surface) drops as much as 60% between these two ages. Therefore, DBT seems to compound the well-known phenomenon of 'brittle old bones'. Old bones can only cope with slow movement, young ones with both slow and fast movement. These observed material characteristics of (i) a shift of the DBT and (ii) a reduced energy absorption capacity appear to contribute at least as much to the loss of bone quality as the various quantity based (lowered bone density and mineral content) explanations of the past. They also provide a new powerful paradigm, which allows us to demonstrate mechanically, and uniquely, how human bone becomes increasingly brittle with age.

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Section: Toughness Vs Strain Rate Figuresupporting

confidence: 70%

Ageing bone fractures: The case of a ductile to brittle transition that shifts with age

Zioupos

Kirchner

Peterlik

2020

Bone

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“…Recently established microdiffraction sources and high-resolution 2D-XRD area detectors [109] enable the analysis of a tooth in situ without destruction. Moreover, it has been possible to apply this nondestructive technique in carious and normal selected areas [86].…”

Section: Mediated Calcium-silicate Mineralizationmentioning

confidence: 99%

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

et al. 2019

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Bioinspired stem cell-based hard tissue engineering includes numerous aspects: The synthesis and fabrication of appropriate scaffold materials, their analytical characterization, and guided osteogenesis using the sustained release of osteoinducing and/or osteoconducting drugs for mesenchymal stem cell differentiation, growth, and proliferation. Here, the effect of silicon- and silicate-containing materials on osteogenesis at the molecular level has been a particular focus within the last decade. This review summarizes recently published scientific results, including material developments and analysis, with a special focus on silicon hybrid bone composites. First, the sources, bioavailability, and functions of silicon on various tissues are discussed. The second focus is on the effects of calcium-silicate biomineralization and corresponding analytical methods in investigating osteogenesis and bone formation. Finally, recent developments in the manufacturing of Si-containing scaffolds are discussed, including in vitro and in vivo studies, as well as recently filed patents that focus on the influence of silicon on hard tissue formation.

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“…These results could provide evidence for structural changes in the polymer itself, which result in improved properties of the resulting material. Another strategy is to mimic processes found in nature, such as the self-healing achieved in human bones [188].…”

Section: Self-healing Of Ionomers After Nonballistic Impactmentioning

confidence: 99%

Intrinsic Self-Healing Polymers Based on Supramolecular Interactions: State of the Art and Future Directions

Enke

Döhler

Bode

et al. 2015

Self-Healing Materials

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Supramolecular polymers are an intriguing class of materials with dynamic behavior as a result of the presence of non-covalent bonds. These bonds include hydrogen bonds, metallopolymers, ionomers, host-guest as well as π-π interactions. The strength of these supramolecular bonds can be tuned by varying the binding motifs. Their reversible and dynamic character can be utilized to engineer self-healing polymers. This review briefly presents the preconditions for design of self-healing polymers and summarizes the development of supramolecular self-healing polymers based on various non-covalent interactions. Furthermore, challenges and perspectives for the understanding of self-healing mechanisms and the preparation of novel materials with enhanced properties are discussed.

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Timescales of self-healing in human bone tissue and polymeric ionic liquids

Cited by 15 publications

References 33 publications

Ageing bone fractures: The case of a ductile to brittle transition that shifts with age

Ageing bone fractures: The case of a ductile to brittle transition that shifts with age

Effects of Silicon Compounds on Biomineralization, Osteogenesis, and Hard Tissue Formation

Intrinsic Self-Healing Polymers Based on Supramolecular Interactions: State of the Art and Future Directions

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