Time Related Neutralization of Two Doses Acetyl Salicylic Acid

Aguejouf, Omar; Malfatti, Emmanuelle; Belon, Philippe; Doutremépuich, Christian

doi:10.1016/s0049-3848(00)00336-4

Cited by 21 publications

(14 citation statements)

References 22 publications

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“…77 B Results on potentized acetyl salicylic acid 35 were confirmed by the same working group. [78][79][80][81] Repeated studies resulting in different effects Other intents of reproduction led to interesting, statistically significant, but modified results: 82 83,84 was found compared to Betti et al 19 on potentized arsenic for meta-analysis of all experiments. B A different result 43 was found on potentized gibberellic acid compared to Baumgartner et al 20 for one specific seed lot of dwarf peas.…”

Section: Initial Studiesmentioning

confidence: 99%

Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study

Endler¹,

Thieves²,

Reich³

et al. 2010

Homeopathy

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We identified 24 experimental models in basic research on high homeopathic potencies, which were repeatedly investigated. 22 models were reproduced with comparable results, 6 models with different results, and repetition showed no results for 15 models. Independent reproductions with either comparable or different results were found for seven models. We encourage further repetition trials of published studies, in order to learn more about the model systems used and in order to test their repeatability.

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Section: Initial Studiesmentioning

confidence: 99%

Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study

Endler¹,

Thieves²,

Reich³

et al. 2010

Homeopathy

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“…After vigorous shaking, 1 ml of this dilution was then mixed with 99 ml of distilled water and vigorously shaken. This process was then repeated 13 times [1,9,10] . Sterilized water for injections (SWI; Aguettant, Lyon, France) was used as control.…”

Section: Drugs Testedmentioning

confidence: 99%

“…The effect of ultralow-dose aspirin (ULDA) in enhancing platelet activity has been described in previous publications [7][8][9][10] . This effect is especially seen in vivo in the presence of platelet-vessel wall interaction, and vascular fragments are needed to visualize it in ex vivo studies.…”

Section: Introductionmentioning

confidence: 99%

Modifications Produced by Indomethacin and <i>L</i>-NAME in the Effect of Ultralow-Dose Aspirin on Platelet Activity in Portal Hypertension

Eizayaga

Aguejouf

Desplat

et al. 2006

Pathophysiol Haemos Thromb

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In our previous study, we demonstrated the effect of ultralow-dose aspirin (ULDA) on platelet activity and bleeding in rats with portal hypertension (PHT) produced by portal vein ligation (PVL). This paper reports modifications in this effect caused by blocking NO production by nitro arginine methyl ester (NAME) and cyclooxygenase (COX) activity with indomethacin. PVL rats and sham-operated controls were treated with placebo, indomethacin or NAME and 30 min thereafter with placebo or ULDA treatment. Platelet activity was studied by a model of in vivo laser-induced thrombus production in the mesenteric circulation, induced hemorrhage time (IHT) and platelet aggregation ex vivo induced by adenosine diphosphate in an aggregometer. The PVL group receiving placebo showed a decreased platelet activity with prolonged IHT, an effect that was reversed by ULDA. Indomethacin induced a decreased platelet activity in the control rats and a prolonged IHT. In PHT with ULDA, in vivo platelet activity was enhanced but the normalization of IHT observed in rats without indomethacin was blunted. The addition of NAME normalized the diminished in vivo platelet aggregation and increased the IHT observed in PVL animals. These changes decreased the effect of ULDA in both sham-operated and PVL animals. The effect of indomethacin was more clearly modified by ULDA than the effect of NAME, thus suggesting that modifications in the COX pathway might alter the effect of ULDA. The simultaneous administration of indomethacin and ULDA could inhibit its beneficial effect on bleeding in rats with PHT.

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“…Other biological models have examined the effects of high dilutions: -Doutremepuich and co-workers [6,31,32,33] demonstrated that, in the rat, high dilutions of aspirin (15 C 10 -30 g/l) have pro-aggregant and prothrombotic activity. They showed that the effect of an injection of 100 mg/kg aspirin is totally inhibited by the extemporaneous injection of aspirin 15 C. -Jonas and co-workers [34] demonstrated that preincubation of neuronal cells with high dilutions of glutamate (10 -22 and 10 -30 g/L) protects against subsequent exposure to toxic levels of glutamate.…”

Section: Discussionmentioning

confidence: 99%

Histamine dilutions modulate basophil activation

Belon¹,

Cumps

Ennis

et al. 2004

Inflammation Research

127

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In 3 different types of experiment, it has been shown that high dilutions of histamine may indeed exert an effect on basophil activity. This activity observed by staining basophils with alcian blue was confirmed by flow cytometry. Inhibition by histamine was reversed by anti-H2 and was not observed with histidine these results being in favour of the specificity of this effect We are however unable to explain our findings and are reporting them to encourage others to investigate this phenomenon.

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Time Related Neutralization of Two Doses Acetyl Salicylic Acid

Cited by 21 publications

References 22 publications

Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study

Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study

Modifications Produced by Indomethacin and <i>L</i>-NAME in the Effect of Ultralow-Dose Aspirin on Platelet Activity in Portal Hypertension

Histamine dilutions modulate basophil activation

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