Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: A review

Chasiotis, Helen; Kolosov, Dennis; Bui, Phuong; Kelly, Scott P.

doi:10.1016/j.resp.2012.05.020

Cited by 185 publications

(137 citation statements)

References 93 publications

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“…In fish, the gill tight junction is composed primarily of TJs, such as occludin, ZO-1 and claudins [93]. The up-regulation of occludin, ZO-1 and claudin 12 mRNA levels revealed that damage to the gill epithelial TJ barrier function was attenuated in grass carp [94].…”

Section: 33mentioning

confidence: 99%

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

Feng

Jiang

et al. 2016

Fish & Shellfish Immunology

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Section: 33mentioning

confidence: 99%

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

Feng

Jiang

et al. 2016

Fish & Shellfish Immunology

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“…Therefore, at higher valine level groups, the changes expression in the PI and MI of NF-kB P65, IkBa and TOR may be attributed to the absorption of valine mainly in the front part of the intestine, but the mechanisms are unknown and need to be further investigated. In fish, intestinal mucosal immune is also depends on intestinal barrier function, which associated with the TJ protein, such as Claudins, Occluding and ZO-1 [19]. Therefore, we next investigated the effects of valine on the TJ protein in the intestine of young grass carp.…”

Section: Valine Regulated Nf-kb P65 Ikba and Tor Genes Expression Inmentioning

confidence: 99%

“…Meanwhile, studies have shown that decreased Claudin b, c and 3 expression reduce intestinal barrier function [19,74]. Besides, in vertebrate, up-regulated Claudin 12 and 15 expression disrupts intestinal barrier function [19,74].…”

Section: Valine Regulated Tj Protein Transcript Abundance In the Intementioning

confidence: 99%

“…Apart from the immune barrier, fish have also established a physical barrier in the intestinal mucosal immune system, which is made up of the epithelial cells and tight junction (TJ) complex [5] consisting of both transmembrane and cytosolic proteins [19]. Transmembrane TJ proteins, such as Occludin and members of the Claudin superfamily, form the physical paracellular barrier [19].…”

Section: Introductionmentioning

confidence: 99%

“…Transmembrane TJ proteins, such as Occludin and members of the Claudin superfamily, form the physical paracellular barrier [19]. The cytosolic TJ proteins such as ZO-1, provide structural support to TJ proteins by linking the transmembrane TJ proteins to the actin cytoskeleton [19].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impaired intestinal mucosal immune system by valine deficiency for young grass carp (Ctenopharyngodon idella) is associated with decreasing immune status and regulating tight junction proteins transcript abundance in the intestine

Luo

Feng

Jiang³

et al. 2014

Fish & Shellfish Immunology

155

113

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The mechanisms of nickel toxicity in aquatic environments: An adverse outcome pathway analysis

Brix

Schlekat²,

Garman³

2017

Enviro Toxic and Chemistry

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Current ecological risk assessment and water quality regulations for nickel (Ni) use mechanistically based, predictive tools such as biotic ligand models (BLMs). However, despite many detailed studies, the precise mechanism(s) of Ni toxicity to aquatic organisms remains elusive. This uncertainty in the mechanism(s) of action for Ni has led to concern over the use of tools like the BLM in some regulatory settings. To address this knowledge gap, the authors used an adverse outcome pathway (AOP) analysis, the first AOP for a metal, to identify multiple potential mechanisms of Ni toxicity and their interactions with freshwater aquatic organisms. The analysis considered potential mechanisms of action based on data from a wide range of organisms in aquatic and terrestrial environments on the premise that molecular initiating events for an essential metal would potentially be conserved across taxa. Through this analysis the authors identified 5 potential molecular initiating events by which Ni may exert toxicity on aquatic organisms: disruption of Ca 2þ homeostasis, disruption of Mg 2þ homeostasis, disruption of Fe 2þ/3þ homeostasis, reactive oxygen species-induced oxidative damage, and an allergic-type response of respiratory epithelia. At the organ level of biological organization, these 5 potential molecular initiating events collapse into 3 potential pathways: reduced Ca 2þ availability to support formation of exoskeleton, shell, and bone for growth; impaired respiration; and cytotoxicity and tumor formation. At the level of the whole organism, the organ-level responses contribute to potential reductions in growth and reproduction and/or alterations in energy metabolism, with several potential feedback loops between each of the pathways. Overall, the present AOP analysis provides a robust framework for future directed studies on the mechanisms of Ni toxicity and for developing AOPs for other metals.

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Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: A review

Cited by 185 publications

References 93 publications

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp ( Ctenopharyngodon idella ) after challenged with Flavobacterium columnare

The impaired intestinal mucosal immune system by valine deficiency for young grass carp (Ctenopharyngodon idella) is associated with decreasing immune status and regulating tight junction proteins transcript abundance in the intestine

The mechanisms of nickel toxicity in aquatic environments: An adverse outcome pathway analysis

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