Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature

Klingen, Tor Audun; Chen, Ying; Gundersen, Marian D; Aas, Hans; Westre, Bjørn; Sauer, Torill

doi:10.1186/1746-1596-5-37

Cited by 26 publications

(27 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The contribution of immunohistochemistry to the correct diagnosis is crucial. TTF-1 is expressed in 68-80% of lung adenocarcinomas, and with the exception of a single case published by Klingen et al (32), TTF-1 has not been reported to stain positively in breast adenocarcinoma (32)(33)(34). The sensitivity of SP-A is substantially less.…”

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 88%

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

et al. 2012

View full text Add to dashboard Cite

Abstract. Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4-1.3% has been reported in the literature. The primary malignancies most commonly metastasizing to the breast are leukemia, lymphoma and malignant melanoma. We present a case of metastasis to the breast from a pulmonary adenocarcinoma, diagnosed concomitantly with the primary tumor. A 43-year-old female presented with dyspnea and a dry cough of 3 weeks' duration. A subsequent chest radiograph revealed a massive pleural effusion. Additionally, on physical examination, a poorly defined mass was noted in the upper outer quadrant of the right breast. The patient underwent bronchoscopy, simple right mastectomy and medical thoracoscopy. Following cytology, histology and immunohistochemistry, primary lung adenocarcinoma with metastasis to the breast and parietal pleura was diagnosed. Histologically, both the primary and metastatic anatomic sites demonstrated a micropapillary component, which has recently been recognized as an important prognostic factor. Although the patient received chemotherapy, she succumbed to her condition within 8 months. Accurate differentiation of metastasis from primary carcinoma is very important as the treatment and prognosis of the two differ significantly. IntroductionThe National Cancer Institute of the USA estimates that, based on current rates, 12.7% of females born today will be diagnosed with breast cancer in their lifetime (1). Although primary breast cancer is the most common malignancy of adult females, metastatic involvement of the breast is rare, with a reported frequency of 0.4-1.3% in clinical series (2-5). Despite its rarity, metastatic breast disease is an significant diagnostic clinical problem, as its treatment differs greatly from that of primary breast cancer. In 1907, Sitzentfrey was the first to publish a case of ovarian carcinoma metastatic to the breast (6). To date, a wide variety of malignancies have now been reported to metastasize to the breast and according to the literature, the most common primary tumors are melanomas and haematological malignancies (5-7). The lung is the most common cancer site in terms of incidence and mortality; however, there have only been a few published cases of pulmonary carcinomas metastasizing to the breast (8-12). Carcinomas with micropapillary components have been reported at several anatomical sites, including the breast, urinary bladder, ovary and major salivary glands (13). Micropapillary components are being increasingly recognized as prognostic predictors in lung adenocarcinomas and according to many studies, this may be a manifestation of aggressive behaviour (14,15). We report the case of a patient with breast metastasis from a pulmonary adenocarcinoma characterized by a micropapillary pattern and diagnosed in conjunction with the primary tumor. Written informed consent was obtained from the patient for publication of this case report and accompanying images. Case reportA 43-year-old, non-smoking housewife presented to the Emergency Departme...

show abstract

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 88%

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Metastatic carcinomas to the lung from the endometrium, endocervix, ovary and colon have been reported to be positive for TTF-1 (Bishop et al 2010, Comperat et al 2005, Klingen et al 2010, Kubba et al 2008, Siami et al 2007, Zhang et al 2009. Although the reported frequency of positivity is low, its misinterpretation can lead to an incorrect diagnosis.…”

Section: Methodsmentioning

confidence: 90%

“…Both TTF-1 and napsin A are useful markers for primary adenocarcinoma of the lung (Bishop et al 2010, Boggaram 2009, Chuman et al 1999, Dejmek et al 2007, Hirano et al 2000, 2003, Ye et al 2011. Studies have shown, however, that TTF-1 and napsin A also can be expressed in extrapulmonary adenocarcinomas and that a small fraction of primary lung adenocarcinomas do not co-express these two markers (Bishop et al 2010, Comperat et al 2005, Klingen et al 2010, Kubba et al 2008, Siami et al 2007, Zhang et al 2009. Additional organ-specifi c biomarkers should be explored to make diagnosis more accurate.…”

mentioning

confidence: 93%

Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung

Hameed

Findeis‐Hosey

et al. 2011

Biotechnic & Histochemistry

View full text Add to dashboard Cite

TTF-1 and napsin A are useful biomarkers for differentiating primary lung adenocarcinoma from metastatic tumors. Studies have shown, however, that TTF-1 and napsin A also can be expressed in extrapulmonary carcinomas, and that a small fraction of primary lung adenocarcinomas do not co-express these two markers. We attempted to determine whether a tissue-specific transcriptional factor, PAX8, can help determine primary sites of lung carcinomas. Immunohistochemical stains for PAX8, TTF-1 and napsin A were performed on 103 cases of metastatic lung carcinomas from a variety of origins and 120 cases of primary lung adenocarcinomas. Our data demonstrated that all 103 metastatic carcinomas were negative for napsin A, while 14 (13.6%; four thyroid, two endometrium, three colon, one prostate, one salivary adenoid cystic, two renal cell carcinomas, and one ovary) showed weak to strong TTF-1 nuclear staining in 5-60% of the tumor cells. All primary lung adenocarcinomas were negative for PAX8, whereas 46 (44.7%) metastatic carcinomas from the kidney (29/33), ovary (6/8), endometrium (5/5), endocervix (1/1), thyroid (4/5) and urinary tract (1/3) were positive for PAX8. Our data demonstrate that of combined use of PAX8, TTF-1 and napsin A is reliable to separate reliably lung primary from metastatic tumors.

show abstract

“…5.2-15% lung adenocarcinomas express GCDFP-1. Mammaglobin is expressed in 48-72.1% mammary adenocarcinomas but stains negatively in pulmonary adenocarcinoma [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Non small cell carcinoma of lung with metachronous breast metastasis and cardiac tamponade: Unusual presentation of a common cancer

Venkatesulu

Mallick

Singh

et al. 2015

Journal of the Egyptian National Cancer Institute

View full text Add to dashboard Cite

show abstract

Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature

Cited by 26 publications

References 13 publications

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung

Non small cell carcinoma of lung with metachronous breast metastasis and cardiac tamponade: Unusual presentation of a common cancer

Contact Info

Product

Resources

About