Thyroid profile in pulmonary tuberculosis patients: a prospective study in a tertiary medical college of southern Odisha

Dash, Manoranjan; Behera, Bibhu P.; Sen, Ranjan

doi:10.18203/2349-3259.ijct20200538

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…A study from India indicated a comparable proportion (2.4%) of overt hypothyroidism with our study. 28 However, the same study reported from India showed a lower euthyroid proportion (58.21%) 28 than the current study.…”

Section: Discussioncontrasting

confidence: 46%

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Biranu¹,

Wolde²,

Negesso³

et al. 2021

IDR

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Background:The emergence of MDR-TB is a global public health problem. Hypothyroidism is one of the severe adverse drug reactions (ADRs) in MDR-TB patients on treatment. Representative data on hypothyroidism and its associated factors among MDR-TB patients are lacking. Objective: To determine thyroid profiles and associated risk factors among multidrugresistant TB patients during therapy with anti-MDR-TB regimen in Saint Peter Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods: A cross-sectional study was conducted in MDR-TB patients in Addis Ababa, Ethiopia. A total of 162 patients, who were older than 18 years, had bacteriologically confirmed MDR-TB and on treatment for more than one month were enrolled consecutively from the TB registration book. However, critically sick patients and those who were receiving additional drugs known to cause severe ADRs were excluded. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the patients. A logistic regression model was used to assess the association between independent and dependent variables. A p-value <0.05 was considered as statistically significant in all analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of hypothyroidism was 32 (19.8%). The presence of co-morbidity, being underweight, and prothionamide use were significantly associated with hypothyroidism in MDR-TB patients on treatment. Conclusion: Hypothyroidism occurs commonly among MDR-TB patients. Presence of comorbidity, being underweight, and prothionamide drug use are the factors associated with hypothyroidism. Monitoring of thyroid function test during MDR-TB treatment and factors associated with hypothyroidism require attention to prevent complication.

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Section: Discussioncontrasting

confidence: 46%

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Biranu¹,

Wolde²,

Negesso³

et al. 2021

IDR

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“…Dash M et al . [ 30 ] found sick euthyroid syndrome in 35.82% of TB patients. Subclinical hypothyroidism increases the risk of depression and reduces adherence to MDR-TB and HIV treatment.…”

Section: Discussionmentioning

confidence: 99%

Socioepidemiological status and clinical outcome of MDR TB patients in a tertiary medical college in Southern Odisha

Behera

Dash

2022

Journal of Family Medicine and Primary Care

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Introduction: India accounts for one-fourth of the global TB burden. The load of drug-resistant TB is of foremost attention and concern at international, regional, and national levels. As per estimates of TB burden in India in 2018, the MDR/RR-TB incidence was 1.30 lakhs. Objectives: Socioepidemiological status and clinical outcome of MDR TB patients in a teaching hospital in tribal area of southern Odisha from 2012-2020. Material and Methods: This is a retrospective observational study accepted by the Institutional Ethics Committee of this tertiary medical college & hospital to which the DRTB centre is attached with the agreement of the program administrators. Inclusion Criteria: Patients with >15 years of age, those patients with pulmonary and extrapulmonary tuberculosis with normal liver enzymes. Exclusion Criteria: Patients having abnormal liver enzymes before treatment, pregnant ladies and children <15 years of age. Results: A total of 40 MDR TB patients were included. The patients’ mean age was 36.65 ± 11.75 years. 65% of the patients had BMI below 18.5 kg/m 2 . 17.5% of patients had comorbidities. Approximately 45% had successful treatment outcomes. Poor treatment outcome includes loss to follow-up in 22.5% and mortality in 12.5%. We did not find any treatment failure. Conclusion: Treatment success outcomes occurred in less than half of the cases. The main predictors of mortality among MDR-TB patients were the presence of comorbidities like anaemia, baseline leucocytosis or lymphopenia, hypoproteinaemia, HIV sero-positivity and smaller baseline BMI.

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Lipid profile, abnormality of serum glucose levels and their associated factors in multidrug-resistant tuberculosis patients

Biranu¹,

Wolde²,

Negesso³

et al. 2021

Glob J Obes Diabetes Metab Syndr

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Background: The rise of multidrug-resistant tuberculosis (MDR-TB) has become a major public health concern around the world. Most patients with pulmonary tuberculosis have low body nutrients, hypocholesterolemia, and lower values were strongly associated with mortality in these patients. Representative data on lipid profile, fasting blood glucose abnormalities and their associated factors among MDR TB patients are lacking. Objective: To determine lipid profile, fasting blood glucose abnormalities and their associated factors among multi-drug resistant TB patients during therapy with anti-MDR-TB regimen in St.peter’s Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods and materials: A cross-sectional study was conducted among multi-drug resistant TB patients during MDR therapy regimen in St. Peter’s Specialized Hospital in Addis Ababa, Ethiopia from January to November 2020.Using the Consecutive sampling method a total of 162 blood samples was collected in SST tubes and analyzed by using the Cobas chemistry analyzer. Data were analyzed using SPSS software version 23 packages. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the study participants. Other associations were performed with Pearson’s correlation coefficient. A p-value of <0.05 at the 95 % confidence level were considered as statistically significant in all the analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of diabetes was 16%. Out of those who had diabetes (9.8%) was newly diagnosed and 6.2% already knew their diabetes status.The most common serum lipid profile abnormalities were 92.6 % HDL-C and 35.8% had TG levels above the borderline. Among MDR-TB patients, 25.9% had a fasting blood glucose level that was higher than normal (hyperglycemic). Conclusion: Lipid profile abnormalities and an increased risk of diabetes have been observed in patients with multidrug-resistant tuberculosis. Factors associated with abnormal blood glucose needed attention to avoid further complications and also the finding of this research calls for the implementation of active case finding of DM in patients diagnosed for MDR-TB.

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Thyroid profile in pulmonary tuberculosis patients: a prospective study in a tertiary medical college of southern Odisha

Cited by 3 publications

References 7 publications

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Socioepidemiological status and clinical outcome of MDR TB patients in a tertiary medical college in Southern Odisha

Lipid profile, abnormality of serum glucose levels and their associated factors in multidrug-resistant tuberculosis patients

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