Lipid profile, abnormality of serum glucose levels and their associated factors in multidrug-resistant tuberculosis patients

Abstract

Background: The rise of multidrug-resistant tuberculosis (MDR-TB) has become a major public health concern around the world. Most patients with pulmonary tuberculosis have low body nutrients, hypocholesterolemia, and lower values were strongly associated with mortality in these patients. Representative data on lipid profile, fasting blood glucose abnormalities and their associated factors among MDR TB patients are lacking. Objective: To determine lipid profile, fasting blood glucose abnormalities and their associated factors among multi-drug resistant TB patients during therapy with anti-MDR-TB regimen in St.peter’s Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods and materials: A cross-sectional study was conducted among multi-drug resistant TB patients during MDR therapy regimen in St. Peter’s Specialized Hospital in Addis Ababa, Ethiopia from January to November 2020.Using the Consecutive sampling method a total of 162 blood samples was collected in SST tubes and analyzed by using the Cobas chemistry analyzer. Data were analyzed using SPSS software version 23 packages. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the study participants. Other associations were performed with Pearson’s correlation coefficient. A p-value of <0.05 at the 95 % confidence level were considered as statistically significant in all the analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of diabetes was 16%. Out of those who had diabetes (9.8%) was newly diagnosed and 6.2% already knew their diabetes status.The most common serum lipid profile abnormalities were 92.6 % HDL-C and 35.8% had TG levels above the borderline. Among MDR-TB patients, 25.9% had a fasting blood glucose level that was higher than normal (hyperglycemic). Conclusion: Lipid profile abnormalities and an increased risk of diabetes have been observed in patients with multidrug-resistant tuberculosis. Factors associated with abnormal blood glucose needed attention to avoid further complications and also the finding of this research calls for the implementation of active case finding of DM in patients diagnosed for MDR-TB.

The cause–effect relation of tuberculosis on incidence of diabetes mellitus

“…High serum triglyceride levels and free fatty acids result in the deposition of lipid granules in various organs, that is known to inhibit insulin-associated signaling cascades resulting in insulin resistance (Boden and Shulman, 2002;Xin et al, 2019). Lipid profile abnormalities and an increased risk of diabetes were observed in multidrug-resistant (MDR) TB patients (Biranu et al, 2021). Lipid mediator, lipoxin and leukotriene derived from arachidonic acid is associated with Mtb susceptibility and disease pathogenicity (Mayer- Barber and Sher, 2015).…”