Thyroid carcinoma and death.A clinicopathological study of 193 autopsies

Silliphant, William M.; Klinck, G. H.; Levitin, Mary S.

doi:10.1002/1097-0142(196404)17:4<513::aid-cncr2820170413>3.0.co;2-2

Cited by 119 publications

(43 citation statements)

References 6 publications

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“…Previous studies had shown that thyroid microcarcinomas may become complicated with distant metastases to the lungs and bone (Boehm et al 1976, Hyman 1979, Osguthorpe & Bratton 1982, Inci et al 1994, Lin et al 1997a, Moosa & Mazzaferri 1997. As the results of our study have shown, mortality will occur if important organs are involved (Sillephant et al 1964, Stage et al 1990. Of the three patients with distant metastases, only one case could be improved to clinical stage 1 after aggressive surgical removal of the bone metastasis.…”

Section: Discussionsupporting

confidence: 51%

Clinical experience in the diagnosis of 127 papillary thyroid microcarcinomas

Lin¹,

Huang²,

Chang³

1998

Endocrine Related Cancer

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Section: Discussionsupporting

confidence: 51%

Clinical experience in the diagnosis of 127 papillary thyroid microcarcinomas

Lin¹,

Huang²,

Chang³

1998

Endocrine Related Cancer

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“…Em um grupo de 70 pacientes que evoluíram com óbito, 61 apresentavam tumor residual na área da glândula e/ou nos linfonodos cervicais 21 . Asfixia foi a causa imediata de óbito entre 26 e 38.5% dos casos 22,23 . Em outra série, recorrência local e regional não foi tão freqüente e a maior parte dos pacientes morreu por metástases a distância ou por outras causas que não o câncer 24 .…”

Section: Discussionunclassified

Carcinoma papilífero de tireóide localmente invasivo

Dedivitis

Guimarães

2002

Rev. Bras. Otorrinolaringol.

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Introdução: O carcinoma bem diferenciado da tireóideinvade estruturas e tecidos moles adjacentes cervicais em uma minoria de pacientes. Entretanto, quando isso ocorre, há significativa morbidade e excessiva mortalidade. Objetivo: Análise retrospectiva dos resultados cirúrgicos. Forma de estudo: Clínico retrospectivo. Material e método: Foram submetidos à tireoidectomia 509 pacientes em nosso serviço de 1994 a 2000. Havia 71 casos de carcinoma papilífero, com 13 casos de extensão extra-tireoidiana (18,3%). Havia cinco pacientes do sexo masculino e oito do feminino, com mediana etária de 57 anos. As estruturas mais freqüentemente invadidas foram: músculos pré-tireoidianos -10 casos; traquéia -9; nervo laríngeo recorrente -6; laringe -4; e esôfago -1. Tireoidectomia total foi realizada em todos os casos, com esvaziamento cervical radical em cinco e de nível VI em seis. Anastomose término-terminal da traquéia foi realizada em cinco pacientes e anastomose entre cricóide e traquéia em dois. Um paciente foi submetido à laringectomia total. Resultados: Um paciente foi a óbito no 10º dia pós-operatório por complicações cardíacas. Dose terapêutica de 131 I foi administrada nos demais pacientes. Todos passaram a receber tiroxina em dose supressiva para a tireotrofina. Outro paciente foi a óbito por causa clínica no 14o mês pós-operatório. Um paciente recusou laringectomia total, estando vivo com doença. Oito pacientes evoluem bem, com seguimento variando de 10 a 49 meses. Um apresentou recidiva local, que foi resgatada cirurgicamente, com bom resultado.

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“…These observations supported an aggressive approach to managing this condition with radical surgery for the primary thyroid and the regional lymphatics. However, in the early 20 th century surgical pathologists were able identify those patients who would have poor outcomes from those who would do better based on light microscopy [3][4][5][6]. The recognition that poorly differentiated or anaplastic cancer was extremely aggressive whereas differentiated thyroid cancers were much less likely to be fatal was a giant step in our understanding of the biology of this disease.…”

Section: Prace Poglądowementioning

confidence: 99%

Wysoko zróżnicowany rak tarczycy — czy nie leczysz swoich pacjentów zbyt intensywnie?

Nixon

2016

Endokrynologia Polska

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Over the last 50 years there has been a move towards more aggressive therapy for well-differentiated thyroid cancer. In recent times, however, international guidelines have shown some trend back towards a more conservative approach to treating low-risk patients. This review explores how the state of the art in well-differentiated thyroid cancer research has evolved in tandem with improvements in riskstratification. A focus on the surgical approach to the primary thyroid tumour and the regional lymphatics in addition to the interplay between surgical decision making and the use of radioactive iodine are presented to allow the reader to determine whether they are now overtreating patients with well-differentiated thyroid cancer. StreszczenieW ciągu ostatnich 50 lat nastąpiła zmiana w leczeniu wysoko zróżnicowanego raka tarczycy na rzecz bardziej agresywnej terapii. Jednakże, całkiem niedawno, międzynarodowe wytyczne wskazały trend w kierunku powrotu ku bardziej konserwatywnemu podejściu w leczeniu pacjentów niskiego ryzyka. W niniejszym artykule opisano jak najnowsze badania na temat wysoko zróżnicowanego raka tarczycy ewoluują równocześnie z ulepszeniami w stratyfikacji ryzyka. Podejście chirurgiczne do raka pierwotnego tarczycy oraz regionalnych węzłów chłonnych przedstawiono wraz ze wzajemnymi zależnościami operacyjnego procesu decyzyjnego i wykorzystaniem radiojodu, aby umożliwić czytelnikowi ustalenie, czy zbyt intensywnie leczy pacjentów z wysoko zróżnicowanym rakiem tarczycy.

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Thyroid carcinoma and death.A clinicopathological study of 193 autopsies

Cited by 119 publications

References 6 publications

Clinical experience in the diagnosis of 127 papillary thyroid microcarcinomas

Clinical experience in the diagnosis of 127 papillary thyroid microcarcinomas

Carcinoma papilífero de tireóide localmente invasivo

Wysoko zróżnicowany rak tarczycy — czy nie leczysz swoich pacjentów zbyt intensywnie?

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