Thyroid autoantibodies in serum samples with abnormal TSH levels

Kontiainen, Sirkka; Melamies, L.; Miettinen, Aaro; Weber, T.

doi:10.1111/j.1699-0463.1994.tb05225.x

Cited by 9 publications

(6 citation statements)

References 14 publications

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“…From another perspective, comparing mean age between positive and negative TAI showed no significant difference between the two groups (p = 0.818), this is consistent with the study done by Poppe et al [24]. A study by Kontiainen et al found an increased prevalence of anti-TPO with age [25]. Another study by Kutteh et al demonstrated elevated antithyroid antibodies titers with age until the age range of 31-35 years, after which titers found to be decreased [26].…”

Section: Discussionsupporting

confidence: 87%

Prevalence of Thyroid Autoimmune Antibodies in Women Seeking Fertility Care in Damascus, Syria

Aljarad¹,

Alhalabi²,

Hamad³

et al. 2019

Cureus

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IntroductionThyroid autoimmune (TAI) disease with a prevalence varying between 5 and 15%, represents the most common endocrine disorder in women with reproductive age. Not only is TAI disease five to 10 folds more common in women than men but also TAI diseases is often undiagnosed because it may be present without overt thyroid dysfunction for several years. Studies found an increased prevalence of TAI in women referred to fertility clinics compared with normal population. In this analysis we aimed to study the prevalence of TAI among women seeking fertility care in Damascus, Syria in order to understand its clinical and public health importance in population.MethodsThis study is a retrospective cross-sectional study on women patients seeking fertility care at Orient Hospital, Damascus city, Syria from April 2011 to March 2018. A total of 2526 women, with available biochemical data of anti-thyroid antibodies (anti-TPO) and anti-thyroglobulin antibodies (anti-TG) were included in our study. Thyroid stimulating hormone (TSH) titers data were also included in the statistical analysis.ResultsTAI was found positive in 559 patients (22.1%) of our studies population. TAI was more prevalent in patients with abnormal TSH levels.ConclusionThyroid autoimmunity prevalence in women seeking fertility care in Damascus, Syria was 22.1% which is significantly higher than normal population. Further studies are needed to assess the relation of these antibodies in thyroid, gynecological and other factors for the Syrian population.

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Section: Discussionsupporting

confidence: 87%

Prevalence of Thyroid Autoimmune Antibodies in Women Seeking Fertility Care in Damascus, Syria

Aljarad¹,

Alhalabi²,

Hamad³

et al. 2019

Cureus

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“…Bjoro et al, 10 in a 20-years follow-up study found that positive anti-TPO were strongly correlated to thyroid dysfunction and the prevalence of elevated TSH was nearly 10-fold higher both in females and males with positive anti-TPO compared with subjects with negative anti-TPO. Kontiainen et al, 11 found elevated levels of anti-TPO antibody in 47% of samples with abnormal and in 12% of samples with normal levels of TSH, indicating a meaningful difference (p<0.001) and also showed that 61% of patients with hypothyroidism and 26% with hyperthyroidism contained this antibody in their sera (p<0.001).…”

Section: Discussionmentioning

confidence: 95%

Study of Clinical Profile of Non-Toxic Goiter With Special Reference to Correlation of Pathology, Lipid Profile and Antibody Level

Saha¹,

Mukherjee²,

Basu³

et al. 2014

jemds

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OBJECTIVE:To evaluate the morphology of non-toxic goiter, the role of auto-immunity and lipid abnormalities in overt and sub-clinical hypothyroid goiter patients. METHODS: A descriptive observational study was undertaken amongst goiter patients without thyrotoxic features comprising 50 randomly selected cases within the range of 12-65years. Goiter patients with thyrotoxic features, acute illness and other visceral diseases were excluded. The patients were evaluated with thyroid function tests, USG-thyroid, FNAC-thyroid, anti-TPO and lipid profile after thorough clinical examination. RESULTS: In my study, most patients were female (with male: female ratio 1:5.25) and were middle aged (between age group 30-49years). Among all patients 60 %( i.e. 30) patients had Hashimoto's thyroiditis, 24% (i.e. 12) patients had diffuse colloid goiter and 16% (i.e. 8) patients had nodular goiter. 52% (i.e. 26) of all patients and 76.6% (i.e. 23) of Hashimoto's goiter patients were anti-TPO positive. Majority of colloid goiter (i.e. 66.7%) and nodular goiter (50%) patients were euthyroid but majority of Hashimoto's goiter patients were hypothyroid (65.38% overt and 33% sub-clinical). Majority of anti-TPO positive patients were hypothyroid (65.38% overt and 30.62% sub-clinical) and majority of anti-TPO negative patients (66.67%) were euthyroid. Within reference range of TSH, there was a linear increase in total serum cholesterol, LDLcholesterol, triglyceride and decrease in HDL-cholesterol with increase in TSH. This lipid profile changes are mainly seen in Hashimoto goiter patients. CONCLUSION: this study emphasizes the role of auto-immunity in non-toxic goiter patients especially Hashimoto's thyroiditis patients and lipid profile changes in those patients.

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“…They demonstrated that 61% of patients with hypothyroidism and 26% with hyperthyroidism had high level of this antibody. 5,12,13 Present study showed mean serum FT3, FT4 and TSH as 1.99+0.572, 1.96+0.530 and 2.49+0.869mIU/L (P-value <0.0001) respectively at confident interval 95%. Madhuvan HS et al showed mean TSH :2.71+/-1.66, T3 :1.20+/-0.52 and T4:6.92+/-1.70.…”

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confidence: 51%

Relationship of thyroid peroxidase antibody test with abnormal thyroid function tests

Shrestha

Karmacharya²,

Giri³

et al. 2017

J Pathol Nep

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Background: Autoimmune thyroid disease results from a complex interaction between genetic and enviromental factors. The aim of this study was to find association of anti-thyroid peroxidase antibody with abnormal thyroid function tests. Materials and Methods: This is a retrospective study, conducted in 160 patients who showed abnormal thyroid function tests in grande city clinic and hospital services and Kantipur dental college for duration of 18 months since Baisakh 2072. Results: Among 160 individuals , 126(78.8%) were female and 34(21.2%) were male. Subclinical hypothyroidism (56.3%) were most common than overthyperthyroidism (18.0%), overthypothyroidism (16.9%) and subclinical hyperthyroidism (8.8%). Anti thyroid peroxidase antibodies test was shown positive in 102/160 (63.8% ) cases. Conclusion: According to the present study, anti-thyroid peroxidase antibody has been significantly associated with thyroid dysfunction, it can be used as diagnostic marker for thyroid autoimmune diathesis.

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Thyroid autoantibodies in serum samples with abnormal TSH levels

Cited by 9 publications

References 14 publications

Prevalence of Thyroid Autoimmune Antibodies in Women Seeking Fertility Care in Damascus, Syria

Prevalence of Thyroid Autoimmune Antibodies in Women Seeking Fertility Care in Damascus, Syria

Study of Clinical Profile of Non-Toxic Goiter With Special Reference to Correlation of Pathology, Lipid Profile and Antibody Level

Relationship of thyroid peroxidase antibody test with abnormal thyroid function tests

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