Prevalence of Thyroid Autoimmune Antibodies in Women Seeking Fertility Care in Damascus, Syria

Aljarad, Mohammad; Alhalabi, Nawras; Hamad, Ahed; Nmr, Nazht; Abbas, Fatima; Alkhatib, Adnan; Alhalabi, Marwan; Al-Hammami, Hisham; Ibrahim, Nazir

doi:10.7759/cureus.5315

Cited by 12 publications

(15 citation statements)

References 26 publications

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“…Antithyroid antibodies can occur in asymptomatic, euthyroid women who have never suffered from a thyroid disease [15][16] . The prevalence of autoimmune thyroid disease (AITD) varying between 5 and 15% in women of reproductive age 17 .…”

Section: Address Of Correspondencementioning

confidence: 99%

Study of Thyroid Autoantibodies in Infertile Women Visiting Chittagong Medical College Hospital, Chattogram, Bangladesh

Zohora

Islam²,

Karmakar

et al. 2023

Eastern Med. Coll. J.

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Background: Thyroid hormones are essential for normal growth, sexual development and reproductive function. Thyroid dysfunction can lead to a variety of gynaecological disorders ranging from menstrual irregularities to infertility. Autoimmune thyroid disease (AITD) is now one of the most important causes of female infertility. Thus, this study was designed to study possible relationship between thyroid disorders, as well as thyroid autoimmunity and unexplained infertility. Methodology: This was a hospital based cross-sectional observational study comprising hundred (100) infertile women aging 18-35 years in Outpatient Department of Obstetrics & Gynaecology and Endocrinology in Chittagong Medical College Hospital and Department of Biochemistry, Chittagong Medical College, Chattogram. Samples were taken by non-probability consecutive sampling. Important variables in this study were serum FT3, FT4, TSH and thyroid antibodies (anti TPO and anti TG). Results: The majority of the infertile women were 21-30 years. Primary and subclinical hypothyroidism were 5% and 17% cases in this study. On the other hand, 22% cases of this study had anti-TG antibody positive and 26% cases had anti-TPO antibody positive. Conclusions: The results of the present study suggest that, increased anti thyroid antibody were associated with a higher prevalence of thyroid dysfunction and mainly hypothyroidism. So, we propose that a systematic screening of TSH, FT3, FT4 and the presence of thyroid antibodies could be considered in all women with a female cause of infertility. EMCJ. July 2022; 7(2): 6-9

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Section: Address Of Correspondencementioning

confidence: 99%

Study of Thyroid Autoantibodies in Infertile Women Visiting Chittagong Medical College Hospital, Chattogram, Bangladesh

Zohora

Islam²,

Karmakar

et al. 2023

Eastern Med. Coll. J.

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“…Therefore, compared to the general population, TAI is more prevalent in women who frequent fertility clinics (6) . The link between TAI and infertility is still mostly hypothetical, though (7) .…”

Section: Introductionmentioning

confidence: 99%

Impact of Thyroid Antibodies on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes

Abdel-Raheem¹,

Abbas²,

Elsayed³

2022

The Egyptian Journal of Hospital Medicine

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Background: Thyroid autoimmunity (TAI) and the success of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been linked in a number of studies; however, the findings are still debatable. Objective: The aim of the current study is to examine whether the presence of thyroid antibodies affects IVF/ICSI results, such as the number of retrieved oocytes, embryo quality, clinical pregnancy rate, and miscarriage rate. Furthermore, subgroup analysis was performed to examine the relationship between the kinds and titers of thyroid antibodies and pregnancy outcomes during IVF/ICSI. Patients and methods: A retrospective cohort study was conducted on 80 infertile women who were nominated for IVF/ICSI; 40 cases with negative and another 40 with positive anti-thyroid antibodies. We compared between both groups regarding clinical/chemical pregnancy rate, doses/duration of induction of ovulation, number of collected oocytes, fertilization rate, quality of transferred embryos and miscarriage rate. Results: Among enrolled cases; 21 (52.5%) had positive anti-TG, 28 (70.0%) had positive anti-TPO and cases that had both anti-TG and TPO were 9 (22.5%), while those who had either anti-TG or TPO were 31 (77.5%). There were no significant differences between study groups regarding embryo quality, clinical/biochemical pregnancy rates, embryo cleavage, induction duration, endometrial thickness and number of fertilized/M2 oocytes or transferred embryos. However, the number of used induction ampoules and abortion rate were statistically significant increased among pregnant women. Conclusion: Infertile women with TAI treated with ICSI had no increased risk of poor IVF/ICSI outcomes except significant increased risk for a first-trimester miscarriage compared with women without TAI.

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“…Antithyroglobuline antibodies (TgAb) are found in 70% of patients with HT. Thyroid autoimmune disease prevalence varies between 5% and 15% in women of reproductive age [3]. The reproductive system is directly affected by thyroid dysfunction as oocytes are affected through thyroid hormone receptors on the surface of these cells [4], and there is an indirect effect through the increased prolactin secretion and disrupted GnRH function [5,6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum anti-Müllerian hormone levels in women with Hashimoto thyroiditis in the reproductive age

et al. 2021

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Background/aim Autoimmune thyroid disease in women is associated with subfertility and early pregnancy loss, and patients with primary ovarian insufficiency have a high prevalence of thyroid autoimmune disorders. The aim of this study was to investigate the association between Hashimoto thyroiditis (HT) and ovarian reserve. Materials and methods Levels of serum thyroid stimulating hormones, thyroid autoantibodies, and anti-Müllerian hormone (AMH) were measured in women with HT and a healthy control group between 2018 and 2019. Results Evaluation was made of 108 premenopausal women with HT, and a control group of 172 healthy females with normal antithyroid antibody levels and thyroid function. Serum AMH levels were determined to be significantly lower in the HT group compared to the control group. Conclusion Ovarian reserve evaluated by serum AMH concentration is affected by thyroid autoimmunity independently of antithyroid antibodies type or titers.

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Prevalence of Thyroid Autoimmune Antibodies in Women Seeking Fertility Care in Damascus, Syria

Cited by 12 publications

References 26 publications

Study of Thyroid Autoantibodies in Infertile Women Visiting Chittagong Medical College Hospital, Chattogram, Bangladesh

Study of Thyroid Autoantibodies in Infertile Women Visiting Chittagong Medical College Hospital, Chattogram, Bangladesh

Impact of Thyroid Antibodies on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes

Evaluation of serum anti-Müllerian hormone levels in women with Hashimoto thyroiditis in the reproductive age

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