Thyroid and Cardiovascular Risk

Waring, Avantika C.; Cappola, Anne R.

doi:10.1007/978-88-470-1143-4_14

Cited by 1 publication

(2 citation statements)

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“…Untreated thyroid diseases may increase the risk of cardiovascular diseases through inter-relationships with dyslipidemia, insulin resistance and vascular endothelial dysfunction (17,18). Therefore, it is probable that FDR of patients with T1DM would also benefit by the current screening strategy for thyroid diseases that are applied for patients with T1DM.…”

Section: Discussionmentioning

confidence: 99%

“…There is increasing evidence of the role of subclinical asymptomatic hypothyroidism in the risk for cardiovascular diseases (17)(18)(19) and even TSH levels between 2.5 and 4.0 mU/liter have been linked to cardiovascular risk. The National Academy of Clinical Biochemistry has suggested that the cutoff for TSH levels should be < 2.5 mU/liter, based on the observation that 95% of the normal population has TSH levels within this range (20).…”

Section: Discussionmentioning

confidence: 99%

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Thyroid disorders are common in first-degree relatives of individuals with type 1 diabetes mellitus

Araújo

Barone

Melleti

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Thyroid diseases are common in individuals with type 1 diabetes mellitus (T1DM) and should be investigated annually in these individuals. The aim of this study was to evaluate the frequency of thyroid diseases in first degree relatives (FDR) of patients with T1DM. Subjects and me thods: Eighty individuals (40 patients with T1DM and 40 FDR) were interviewed and blood was sampled for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase (TPO) antibodies measurement. Autoantibodies against glutamic acid decarboxylase 65 (GAD65), islet antigen-2 (IA2) and autoantibodies against insulin (AAI) were measured in FDR. Results: We found a similar prevalence of thyroid dysfunction in patients with T1DM and their FDR (22.5% vs. 27.5%; p = 0,79). There were no differences in serum TSH levels (p = 0.29), FT4 (p = 0,45), frequency of abnormal TSH (p = 0.28), positive TPO antibodies (p = 0.13), titers of TPO antibodies (in positive cases) between patients with T1DM and their FDR (p = 0.94). Conclusions: Thyroid abnormalities seem to be common not only in patients with T1DM but also in their FDR, which suggests that screening strategies for thyroid diseases might also be useful to these individuals. Arch Endocrinol Metab. 2015;59(2):112-5

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Section: Discussionmentioning

confidence: 99%