2016
DOI: 10.1590/1806-9282.62.06.561
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Thyroid abnormalities in term infants with fungal sepsis

Abstract: Objective: To describe thyroid alterations in term newborns (TNB) with fungal sepsis during NICU hospitalization. Method: The study included six TNB that during the clinical and laboratory manifestations of sepsis with positive cultures for fungus showed changes in thyroid hormones, called low T3 syndrome and low T3-T4 syndrome. TNB that could present hormonal changes caused by disease as those born to mothers with thyroid disease, or who had perinatal asphyxia and major surgeries were excluded. Results: Of si… Show more

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Cited by 6 publications
(8 citation statements)
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References 36 publications
(149 reference statements)
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“…Characteristic patterns of NTIS have been described in a multitude of acute and chronic somatic illnesses including states of shock (284), circulatory arrest (285, 286), respiratory failure (65), community-acquired pneumonia (287), sepsis (288), chronic respiratory (289, 290) and cardiovascular (61, 64, 66, 291, 292) disease, renal failure (293298), COPD (289), gastrointestinal diseases (299301), autoimmune diseases (71, 302, 303), and cancer (130, 290, 304). Phenotypes of NTIS with high and high-normal FT4 concentrations have been described in dementia and frailty in elderly persons (305).…”
Section: Thyroid Allostasis In Various Physiological and Pathologicalmentioning
confidence: 99%
“…Characteristic patterns of NTIS have been described in a multitude of acute and chronic somatic illnesses including states of shock (284), circulatory arrest (285, 286), respiratory failure (65), community-acquired pneumonia (287), sepsis (288), chronic respiratory (289, 290) and cardiovascular (61, 64, 66, 291, 292) disease, renal failure (293298), COPD (289), gastrointestinal diseases (299301), autoimmune diseases (71, 302, 303), and cancer (130, 290, 304). Phenotypes of NTIS with high and high-normal FT4 concentrations have been described in dementia and frailty in elderly persons (305).…”
Section: Thyroid Allostasis In Various Physiological and Pathologicalmentioning
confidence: 99%
“…This activity may be attributed to the complex pathophysiological interplay between thyroidstimulating hormone (TSH) and the immune system [3,4]. The various lymphokines and monokines factors act as a marker in sepsis and can influence the hypothalamic-pituitary-thyroid axis modulating thyroid hormone levels [3,5].Multiple studies have been performed in the recent past showing correlation of sepsis and thyroid hormones [6][7][8][9][10][11][12]. A study conducted by Kurt et al showed a significant change in thyroid hormone levels before and after the treatment of neonatal sepsis with antibiotics [6].…”
mentioning
confidence: 99%
“…These findings also suggest that thyroid hormone levels improve when antenatal corticosteroids are used [14]. Corticosteroids not only stimulate lung maturity but also induce euthyroidism that ultimately improves the survival of neonates [12].…”
Section: Discussionmentioning
confidence: 85%
“…Studies [11] have also suggested a reduced action of T4 in peripheral tissues, through the demonstration of low serum levels of the angiotensin-converting enzyme, which is stimulated by thyroid hormones. In the recovery phase, there may be a temporary increase in TSH [12].…”
Section: Introductionmentioning
confidence: 99%