Thymus musilii Velen. as a promising source of potent bioactive compounds with its pharmacological properties: In vitro and in silico analysis

Mseddi, Khalil; Alimi, Fathi; Noumi, Emira; Veettil, Vajid N.; Deshpande, Sumukh; Adnan, Mohd; Hamdi, Abdelaziz; Elkahoui, Salem; Alghamdi, Ahmed; Kadri, Adel; Patel, Mitesh

doi:10.1016/j.arabjc.2020.06.032

Cited by 62 publications

(44 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidants have been applied to remove the deleterious detrimental effects of ROS, by donating their own electrons, and therefore preventing them from capturing electrons from other important molecules, such as DNA, proteins and lipids [ 1 ]. Thus, various medicinal herbs and plants have been reported to offer promising biosources of bioactive molecules with various biological properties such as antioxidant [ 9 , 10 , 11 , 12 , 13 , 14 ], antimicrobial [ 10 , 12 , 13 , 14 , 15 ], antibiofilm [ 16 , 17 ], antiquorum sensing [ 11 , 17 , 18 ] and antidiabetic [ 19 ]. On the other hand, several treatments are available for the wound management such as analgesics, antibiotics and nonsteroidal anti-inflammatory drugs, but most of them produce numerous unwanted side effects [ 8 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein

Alminderej

Bakari

Almundarij

et al. 2021

Plants

Self Cite

View full text Add to dashboard Cite

Piper cubeba is an important plant commonly known as cubeb or Java pepper, and it is cultivated for its fruit and essential oils, largely used to treat various diseases. Up to today, there was no scientific report on wound healing activity. Thus, this study was initiated to evaluate for the first time the antimicrobial activity and wound healing potential of a new chemotype from Piper cubeba essential oil (PCEO) from fruits. Thirteen microbial strains have been selected to investigate the antimicrobial potential of PCEO. For the evaluation of the wound healing potential, sixteen rats were excised on the dorsal back and divided into four groups. The effect of PCEO on the malondialdehyde (MDA) and superoxide dismutase (SOD) activities in the healed wound area of rats and the biochemical parameters and skin histological analysis were also assessed. Results: Data showed that PCEO exhibited a powerful antimicrobial potential especially against Listeria monocytogenes and Staphylococcus aureus. In addition, the topical application of PCEO cream appears to increase the SOD level, wound healing and contraction but reduced the MDA amount suggesting an impressive and a rapid cutaneous healing power. Additionally, histopathological analysis of the granulation tissue revealed that the derma is properly restored and arranged after treatment with PCEO. The docking analysis of PCEO constituents against S. aureus tyrosyl-tRNA synthetase enzyme showed binding energies values in the range of −7.2 to −4.8 kcal/mol. In conclusion, the topic use of PCEO healing cream showed significant effect in accelerating the healing process, which may be attributed to the synergetic effect of antioxidant and antimicrobial properties of PCEO volatile constituents, making it a relevant therapeutic agent for the management of wounds and therefore confirming the popular traditional uses of this plant.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED: Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein

Alminderej

Bakari

Almundarij

et al. 2021

Plants

Self Cite

View full text Add to dashboard Cite

show abstract

“…The results reported showed that IC50 values were 90 µg/mL (A549), 106 µg/mL (BT20), 140 µg/mL (MCF-7) and 120 µg/mL (PC12). The cytotoxic properties of T. polium aerial parts can be attributed the presence in the organic extracts of some diterpenoids and their acyl derivatives (teucvin and teucvidin), flavonoids (cirsiliol, cirsimaritin, cirsilineol, salvigenin, and 5-hydroxy-6,7,3′,4′-tetramethoxyllavone), saponin poliusaposide [ 52 ], and selenium [ 53 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…For the last several years, T. polium has been tested and was considered to be a plant rich in antibacterial compounds [ 56 ]. In fact, it exerts antibacterial activities against Gram-negative and positive bacteria [ 54 ]. Many research groups [ 59 , 64 , 65 , 66 ] obtained the same result and demonstrated that the aspect, constituents, and architecture of the membranes of Gram-negative bacteria makes them more susceptible to the bioactive compounds present in methanolic extract.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

Self Cite

View full text Add to dashboard Cite

The chemical profile of Teucrium polium L. (T. polium) methanolic extract was tested using liquid chromatography coupled with high resolution mass spectrometry (HR-LCMS). Disc diffusion and microdilution assays were used for the antimicrobial activities. Coxsackievirus B-3 (CVB3) and Herpes simplex virus type 2 (HSV-2) were used for the antiviral activities. Chromobacterium violaceum (ATCC 12472 and CV026) and Pseudomonas aeruginosa PAO1 were used as starter strains for the anti-quorum sensing tests. Isoprenoids are the main class of compounds identified, and 13R-hydroxy-9E,11Z-octadecadienoic acid, valtratum, rhoifolin, sericetin diacetate, and dihydrosamidin were the dominant phytoconstituents. The highest mean diameter of growth inhibition zone was recorded for Acinetobacter baumannii (19.33 ± 1.15 mm). The minimal inhibitory concentrations were ranging from 6.25 to 25 mg/mL for bacterial strains, and from 6.25 to 25 mg/mL for Candida species. The 50% cytotoxic concentration on VERO (African Green Monkey Kidney) cell lines was estimated at 209 µg/mL. No antiviral activity was recorded. Additionally, T. polium extract was able to inhibit P. aeruginosa PAO1 motility in a concentration-dependent manner. However, the tested extract was able to inhibit 23.66% of the swarming and 35.25% of swimming capacities of PAO1 at 100 µg/mL. These results highlighted the role of germander as a potent antimicrobial agent that can interfere with the virulence factors controlled by the quorum-sensing systems.

show abstract

“…From decades, plants are well conceded as a source of medicine against different kinds of human ailments [ 1 , 2 , 3 ]. Several examples of plant-based drugs include nicotine (antimicrobial), nordihydroguaiaretic acid (antioxidant), vinblastine (anticancer), aescin (anti-inflammatory), acetyldigoxin (cardiotonic), l -dopa (antiparkinsonism), etc.…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of Selaginella repanda with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines

et al. 2021

Self Cite

View full text Add to dashboard Cite

In this study, we investigated the bioactive potential (antibacterial and antioxidant), anticancer activity and detailed phytochemical analysis of Selaginellarepanda (S. repanda) ethanolic crude extract for the very first time using different in vitro approaches. Furthermore, computer-aided prediction of pharmacokinetic properties and safety profile of the identified phytoconstituents were also employed in order to provide some useful insights for drug discovery. S. repanda, which is a rich source of potent natural bioactive compounds, showed promising antibacterial activity against the tested pathogenic bacteria (S. aureus, P. aeruginosa, E. coli and S. flexneri). The crude extract displayed favorable antioxidant activity against both 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 231.6 μg/mL) and H2O2 (IC50 = 288.3 μg/mL) molecules. S. repanda also showed favorable and effective anticancer activity against all three malignant cancer cells in a dose/time dependent manner. Higher activity was found against lung (A549) (IC50 = 341.1 μg/mL), followed by colon (HCT-116) (IC50 = 378.8 μg/mL) and breast (MCF-7) (IC50 = 428.3 μg/mL) cancer cells. High resolution-liquid chromatography–mass spectrometry (HR-LC–MS) data of S. repanda crude extract revealed the presence of diverse bioactive/chemical components, including fatty acids, alcohol, sugar, flavonoids, alkaloids, terpenoids, coumarins and phenolics, which can be the basis and major cause for its bioactive potential. Therefore, achieved results from this study confirmed the efficacy of S. repanda and a prospective source of naturally active biomolecules with antibacterial, antioxidant and anticancer potential. These phytocompounds alone with their favorable pharmacokinetics profile suggests good lead and efficiency of S. repanda with no toxicity risks. Finally, further in vivo experimental investigations can be promoted as probable candidates for various therapeutic functions, drug discovery and development.

show abstract

Thymus musilii Velen. as a promising source of potent bioactive compounds with its pharmacological properties: In vitro and in silico analysis

Cited by 62 publications

References 97 publications

RETRACTED: Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein

RETRACTED: Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of Selaginella repanda with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines

Contact Info

Product

Resources

About