Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum

Özata, Funda; Ural, Kerem

doi:10.21897/rmvz.90

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…Our study also demonstrated elevated MPV levels in leishmaniatic dogs and revealed a positive correlation between MPV and vitamin D levels. However, changes in mean MPV values were not statistically significant in dogs infected with Ehrlichia canis and Anaplasma phgocytophilium (24). In this study, dogs infected with leishmaniasis presented increased MPV values, which suggests that larger platelets play an active role in homeostasis (13,14).…”

Section: Resultscontrasting

confidence: 56%

Relationship between mean platelet volume, low-grade systemic coagulation and vitamin D deficiency in canine visceral leishmaniasis

Erdoğan¹,

Ural²,

Paşa³

2019

Medycyna Weterynaryjna

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Canine visceral leishmaniasis is associated with cardiac changes. This study was designed to test the hypothesis that vitamin D and coagulation parameters, such as D-dimer, activated partial thromboplastin time (APTT), partial thromboplastin time (PT), mean platelet volume (MPV), and white blood cell (WBC) levels, change in different stages of canine visceral leishmaniasis (CVL). Thirty-two dogs diagnosed with CVL were classified into four different groups: stage I (mild disease), stage II (moderate disease), stage III (severe disease), stage IV (very severe disease), and healthy controls. The groups were based on clinical signs, rapid ELISA/IFAT, hematological and serum biochemical tests, and urinary protein/creatinine ratios. Serum vitamin D levels were positively correlated with MPV (r = 0.503), but negatively correlated with D-dimer (r =-0.326), APTT (r =-0.361), PT (r =-0.289), and WBC (r = -0.384). The dogs with leishmaniasis showed increased WBC levels compared with the control group. Similarly, their vitamin D levels were significantly decreased compared with those in the control group (p<0.05). Severely diseased dogs (stage IV leishmaniasis) showed the lowest vitamin D levels, but there were no significant differences between dogs in the various stages of leishmaniasis. The evidence provided by this study indicates that the CVL dogs had low-grade systemic coagulation and fibrinolytic activation, as indicated by elevated MPV, PT, WBC and D-dimer levels, which may be used as a biomarker of low-grade systemic inflammation in CVL.

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Section: Resultscontrasting

confidence: 56%

Relationship between mean platelet volume, low-grade systemic coagulation and vitamin D deficiency in canine visceral leishmaniasis

Erdoğan¹,

Ural²,

Paşa³

2019

Medycyna Weterynaryjna

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Serological and molecular investigation of Ehrlichia spp. and Anaplasma spp. in ticks and blood of dogs, in the Thrace Region of Turkey

Çetinkaya

Matur

Akyazı

et al. 2016

Ticks and Tick-borne Diseases

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Relationship between ocular abnormalities and hematologic alterations in patients infected naturally by Ehrlichia canis

et al. 2021

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To determine the association between ocular abnormalities and hematologic findings in Ehrlichia canis-infected dogs, 120 dogs suspected of canine ehrlichiosis were studied. All patients were subjected to rapid serologic diagnostic test for Ehrlichia canis, and the diagnosis was confirmed by quantitative PCR. PCR-positive patients underwent ophthalmologic examination and a hemogram and were grouped into patients with thrombocytopenia and anemia (G1), patients with thrombocytopenia (G2), and patients without hematologic disorders (G3). For ophthalmic evaluation, the patients were grouped into those having mild, severe, both mild and severe, and no ocular alterations. All patients presented with uveitis (100%). Severe ocular disorders predominated in G1 and G2 patients. Dogs with anemia and leukopenia showed severe ocular disorders. In dogs with a greater number of leukocytes and copies/µl of the TRAG gene, the intraocular pressure (IOP) tends to decrease and vice versa (r = −0.23, r = −0.26). In conclusion, uveitis is the earliest ocular alteration of canine ehrlichiosis. The severity of ocular abnormalities in patients with ehrlichiosis is associated with thrombocytopenia and may be aggravated by anemia and leukopenia. The hemogram and IOP are useful tools for predicting eye involvement in Ehrlichia canis-infected patients. In regions where Ehrlichia canis is endemic, the use of the tonometer should be routinely in dog general consultation.

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Thrombocyte indices in dogs infected with Ehrlichia canis and Anaplasma phagocytophilum

Cited by 5 publications

References 15 publications

Relationship between mean platelet volume, low-grade systemic coagulation and vitamin D deficiency in canine visceral leishmaniasis

Relationship between mean platelet volume, low-grade systemic coagulation and vitamin D deficiency in canine visceral leishmaniasis

Serological and molecular investigation of Ehrlichia spp. and Anaplasma spp. in ticks and blood of dogs, in the Thrace Region of Turkey

Relationship between ocular abnormalities and hematologic alterations in patients infected naturally by Ehrlichia canis

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