Three-phase hollow-fiber liquid-phase microextraction combined with HPLC-UV for the determination of isothiazolinone biocides in adhesives used for food packaging materials

Rosero-Moreano, Milton; Canellas, Elena; Nerı́n, Cristina

doi:10.1002/jssc.201300840

Cited by 29 publications

(21 citation statements)

References 36 publications

(42 reference statements)

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“…Moreover, the available information refers mainly to cosmetics, which are frequently reformulated, and the majority of which stay on the market for < 5 years (14). The methodology for the analytical determination of isothiazolinones has been developed mainly for environmental water matrices (18)(19)(20)(21)(22), food packaging materials (23,24), detergents (14,16,17), and cosmetic matrices (14,17,20,(25)(26)(27), using either liquid chromatography (LC), high-performance liquid chromatography (HPLC), or, to a lesser extent, gas chromatography.…”

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confidence: 99%

Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

et al. 2016

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SummaryBackground. In recent years, the frequency of contact allergy to isothiazolinones has increased alarmingly in Europe, but only limited data are available on concentrations of isothiazolinones in consumer products. Objectives. To examine the current frequency of isothiazolinones [methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT)] in a wide array of detergents and cosmetics relevant for the Swiss population. Methods. By means of a market survey, the occurrence of isothiazolinones was investigated in 1948 consumer products. Of these, 88 products were analysed by liquid chromatography-high-resolution mass spectrometry after ultrasonic extraction. Results. Only 7.6% of all cosmetics contained isothiazolinones, but the prevalence in detergents was much higher (42.9%). The measured concentration ranges in detergents were 4.3-10, 3.5-279, 3.8-186 and 7.9 ppm (one product only) for MI, MCI, BIT, and OIT, respectively. For cosmetics, these were 1.3-133 and 4.8 ppm (one product only) for MI and MCI, respectively. Conclusions. Our study has shown that high concentrations of isothiazolinones (including MI) can be found in a large variety of products, in particular in detergents. Therefore, the safe use of these preservatives should be re-evaluated by including detergents in the exposure assessment.

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Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

et al. 2016

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“…Thus, LPME as a miniaturized form of LLE is introduced to eliminate these limitations. LPME is carried out in various shapes including single drop microextraction [12], dispersive liquid-liquid microextraction (DLLME) [13,14], and hollow fiber LPME [15,16]. Among them, DLLME is widely used for the separation of various analytes from different samples because it has several good advantages such as having a simple and rapid procedure, and high enhancement factor [13,17].…”

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confidence: 99%

In‐syringe vortex‐assisted emulsification microextraction with solidified floating organic drop for the separation of aflatoxins from feed before their determination by HPLC

Asadi

2018

Separation Science Plus

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A simple and rapid in‐syringe vortex‐assisted emulsification microextraction with solidified floating organic drop was developed for the extraction of aflatoxins (B1 and B2) from feed before their determined by high‐performance liquid chromatography. Several experimental factors affect the microextraction efficiency such as sample pH, vortex time, type of extraction solvent, and sample volume that have been evaluated and optimized. The calibration curves were linear in the range of 50.0–500.0 and 40.0–400.0 ng kg−1 for aflatoxin B1 and aflatoxin B2, respectively. The limits of detection were found to be 16.0 and 12.0 ng kg−1 for aflatoxin B1 and aflatoxin B2, respectively. The inter‐day and intra‐day precisions of the developed method were in the range of 5.3–9.3%. Finally, the developed microextraction method was successfully used in the extraction and quantification of aflatoxins in several feed samples.

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“…LPME is the miniaturized implementation of the conventional LLE, in which the amount of organic solvents is greatly reduced. LPME has been performed in different modes, including single drop microextraction (SDME) , headspace LPME , hollow‐fiber (HF) LPME , dispersive liquid–liquid microextraction (DLLME) , and solidified floating organic drop microextraction (SFODME) . LPME has also been the subject of several reviews .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous extraction and quantification of lamotrigine, phenobarbital, and phenytoin in human plasma and urine samples using solidified floating organic drop microextraction and high‐performance liquid chromatography

Asadi

Dadfarnia

Shabani

et al. 2015

J of Separation Science

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A novel and simple method based on solidified floating organic drop microextraction followed by high-performance liquid chromatography with ultraviolet detection has been developed for simultaneous preconcentration and determination of phenobarbital, lamotrigine, and phenytoin in human plasma and urine samples. Factors affecting microextraction efficiency such as the type and volume of the extraction solvent, sample pH, extraction time, stirring rate, extraction temperature, ionic strength, and sample volume were optimized. Under the optimum conditions (i.e. extraction solvent, 1-undecanol (40 μL); sample pH, 8.0; temperature, 25°C; stirring rate, 500 rpm; sample volume, 7 mL; potassium chloride concentration, 5% and extraction time, 50 min), the limits of detection for phenobarbital, lamotrigine, and phenytoin were 1.0, 0.1, and 0.3 μg/L, respectively. Also, the calibration curves for phenobarbital, lamotrigine, and phenytoin were linear in the concentration range of 2.0-300.0, 0.3-200.0, and 1.0-200.0 μg/L, respectively. The relative standard deviations for six replicate extractions and determinations of phenobarbital, lamotrigine, and phenytoin at 50 μg/L level were less than 4.6%. The method was successfully applied to determine phenobarbital, lamotrigine, and phenytoin in plasma and urine samples.

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Three-phase hollow-fiber liquid-phase microextraction combined with HPLC-UV for the determination of isothiazolinone biocides in adhesives used for food packaging materials

Cited by 29 publications

References 36 publications

Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

In‐syringe vortex‐assisted emulsification microextraction with solidified floating organic drop for the separation of aflatoxins from feed before their determination by HPLC

Simultaneous extraction and quantification of lamotrigine, phenobarbital, and phenytoin in human plasma and urine samples using solidified floating organic drop microextraction and high‐performance liquid chromatography

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